Carnitine promotes recovery from oxidative stress and extends lifespan in C. elegans

Liu, Dongliang; Zeng, Xiaofang; Li, Le; Ou, Zhenglin

doi:10.18632/aging.202187

Cited by 17 publications

(12 citation statements)

References 62 publications

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“…There has also been evidence of antioxidant defense dysregulation, as well as opposite relationships between antioxidant capacity and body fat percentage [11]. This could explain the reduced L-carnitine levels in obesity group in the present study, which may play a role in the loss of mitochondrial function since that L-carnitine have a role in the recovery from OS [22].…”

Section: Discussionmentioning

confidence: 49%

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Obesity and Mitochondrial Function in Children: A case–control study

Alkataan

Fawzi

2022

Open Access Maced J Med Sci

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OBJECTIVES: Childhood obesity has increased over the past years worldwide. Therefore, changes in mitochondrial function as the risk factors of obesity in children need to consider. AIM: The study aimed to evaluate the connection between obesity and mitochondrial function in obese children. PATIENTS AND METHODS: This study was a case–control study conducted in the primary school children in Mosul city. The study included 100 children, with an age ranged from 6 to 12 years. Fifty child with obesity (BMI ≥ 95th percentile) for children enrolled in this work and compared to 50 control with BMI <95th percentile. Mitochondrial function assessed by measurement of serum lactic acid, lactate/pyruvate ratio, and L-carnitine and mt-DNA copy number. RESULTS: Serum lactate and the lactate/pyruvate ratio were significantly higher in obese children than in the control group, while serum pyruvate levels in children with obesity are not significantly different from those in the control group. Serum levels of L-carnitine and mt-DNA copy number significantly reduced in obese children comparison to the control group. CONCLUSION: Changes of mitochondrial function may be involved in obesity of children.

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Section: Discussionmentioning

confidence: 49%

“…Furthermore, this study found that serum levels of L-carnitine have significantly reduced in children with obesity. The recovery of L-carnitine in OS might be important for health [22].…”

Section: Discussionmentioning

confidence: 99%

Obesity and Mitochondrial Function in Children: A case–control study

Alkataan

Fawzi

2022

Open Access Maced J Med Sci

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“…The fatty acid metabolic disorder in MTKO mice may have led to high-fat diet-induced fatty liver and obesity [ 66 ] and a shortened lifespan [ 20 ]. Carnitine protects from oxidative stress and extends the lifespan of C. elegans [ 67 ]. Older MTKO mice with low L-carnitine plasma levels may be vulnerable to oxidative stress enhanced by the deficiency of MT, as MT is an antioxidant.…”

Section: Discussionmentioning

confidence: 99%

Metabolomic profiling of plasma from middle-aged and advanced-age male mice reveals the metabolic abnormalities of carnitine biosynthesis in metallothionein gene knockout mice

Kadota

Yano

Kawakami

et al. 2021

Aging

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Metallothionein (MT) is a family of low molecular weight, cysteine-rich proteins that regulate zinc homeostasis and have potential protective effects against oxidative stress and toxic metals. MT1 and MT2 gene knockout (MTKO) mice show shorter lifespans than wild-type (WT) mice. In this study, we aimed to investigate how MT gene deficiency accelerates aging. We performed comparative metabolomic analyses of plasma between MTKO and WT male mice at middle age (50-week-old) and advanced age (100-week-old) using liquid chromatography with time-of-flight mass spectrometry (LC-TOF-MS). The concentration of N 6, N 6, N 6-trimethyl-L-lysine (TML), which is a metabolic intermediate in carnitine biosynthesis, was consistently higher in the plasma of MTKO mice compared to that of WT mice at middle and advanced age. Quantitative reverse transcription PCR (RT-PCR) analysis revealed remarkably lower mRNA levels of Tmlhe , which encodes TML dioxygenase, in the liver and kidney of male MTKO mice compared to that of WT mice. L-carnitine is essential for β-oxidation of long-chain fatty acids in mitochondria, the activity of which is closely related to aging. Our results suggest that reduced carnitine biosynthesis capacity in MTKO mice compared to WT mice led to metabolic disorders of fatty acids in mitochondria in MTKO mice, which may have caused shortened lifespans.

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“…[ 177 ] The GPS‐induced extension of RLS was abolished in a strain lacking ATG32 , a gene required for mitophagy, and RLS extension by GPS may therefore depend on mitophagy. [ 178 ] However, CLS extension also occurs in Δ atg32 cells, so mitophagy may be not involved in CLS extension by GPS. [ 165 ]…”

Section: Low‐molecular Weight Compounds That Extend the Chronological...mentioning

confidence: 99%

Low‐Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe

Ohtsuka,

Shimasaki,

Aiba

2024

Advanced Biology

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Yeast is an excellent model organism for research for regulating aging and lifespan, and the studies have made many contributions to date, including identifying various factors and signaling pathways related to aging and lifespan. More than 20 years have passed since molecular biological perspectives are adopted in this research field, and intracellular factors and signal pathways that control aging and lifespan have evolutionarily conserved from yeast to mammals. Furthermore, these findings have been applied to control the aging and lifespan of various model organisms by adjustment of the nutritional environment, genetic manipulation, and drug treatment using low‐molecular weight compounds. Among these, drug treatment is easier than the other methods, and research into drugs that regulate aging and lifespan is consequently expected to become more active. Chronological lifespan, a definition of yeast lifespan, refers to the survival period of a cell population under nondividing conditions. Herein, low‐molecular weight compounds are summarized that extend the chronological lifespan of Saccharomyces cerevisiae and Schizosaccharomyces pombe, along with their intracellular functions. The low‐molecular weight compounds are also discussed that extend the lifespan of other model organisms. Compounds that have so far only been studied in yeast may soon extend lifespan in other organisms.

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Carnitine promotes recovery from oxidative stress and extends lifespan in C. elegans

Cited by 17 publications

References 62 publications

Obesity and Mitochondrial Function in Children: A case–control study

Obesity and Mitochondrial Function in Children: A case–control study

Metabolomic profiling of plasma from middle-aged and advanced-age male mice reveals the metabolic abnormalities of carnitine biosynthesis in metallothionein gene knockout mice

Low‐Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe

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