Carnosic acid inhibits reactive oxygen species-dependent neutrophil extracellular trap formation and ameliorates acute respiratory distress syndrome

Tsai, Yung-Fong; Yang, Sung-Byung; Hsu, Yun-Hsuan; Chen, Chun-Yu; Chen, Po‐Jen; Syu, Yu-Ting; Lin, Ching‐Hsiung; Hwang, Tsong‐Long

doi:10.1016/j.lfs.2022.121334

Cited by 11 publications

(3 citation statements)

References 54 publications

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“…Furthermore, decreasing toxic mediators produced by activated neutrophils reduced inflammatory injury. Excess elastase activity in inflamed lung tissue of ARDS patients and animal studies induces pulmonary tissue damage and affects recovery (Pan et al, 2023; Tsai, Yang, et al, 2022). Blocking elastase activity attenuates endotoxemic lung injury (Suzuki et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Targeting formyl peptide receptor 1 with anteiso‐C13‐surfactin for neutrophil‐dominant acute respiratory distress syndrome

Yang

Wang

et al. 2023

British J Pharmacology

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Background and Purpose: Acute respiratory distress syndrome (ARDS) is a catastrophic pulmonary inflammatory dysfunction with a high mortality rate. An overwhelming immune response by neutrophils is a key feature in infective or sterile ARDS. The formyl peptide receptor 1 (FPR1) is a crucial damage-sensing receptor for inflammatory reactions in the initiation and progression of neutrophil-mediated ARDS. However, effective targets for controlling dysregulated neutrophilic inflammatory injuries in ARDS are limited.Experimental Approach: Human neutrophils were used to explore the antiinflammatory effects of cyclic lipopeptide anteiso-C13-surfactin (IA-1) from marine Bacillus amyloliquefaciens. The lipopolysaccharide-induced model of ARDS in mice was used to determine the therapeutic potential of IA-1 in ARDS. Lung tissues were harvested for histology analyses.

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Section: Discussionmentioning

confidence: 99%

Targeting formyl peptide receptor 1 with anteiso‐C13‐surfactin for neutrophil‐dominant acute respiratory distress syndrome

Yang

Wang

et al. 2023

British J Pharmacology

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“…Naturally occurring aromatic abietane diterpenoids exhibit a broad range of biological properties. 31 Particularly, carnosic acid and carnosol are known to possess potent antioxidant, 32,33 anti-inflammatory, 34 anticancer 35 and anti-fungal [36][37][38] properties, among others, and the literature is full of works on their therapeutic mechanisms and potential clinical applications. However, only a few works have been reported on their potential on crops protection.…”

Section: Anti-fungal Activity Assays Of Pure Compoundsmentioning

confidence: 99%

Bio‐guided isolation of aromatic abietane diterpenoids from Salvia canariensis as biopesticides in the control of phytopathogenic fungi

López‐Cabeza,

Rodríguez‐Sabina,

Reyes

et al. 2024

Pest Management Science

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BackgroundBiofungicides arise as a promising alternative to the indiscriminate use of harmful synthetic fungicides in crop management.ResultsThe present study reports the bio‐guided fractionation of an endemic plant from the Canary Islands, Salvia canariensis against the phytopathogens, Alternaria alternata, Botrytis cinerea, and Fusarium oxysporum. This procedure allowed identifying a series of diterpenoids with an abietane skeleton (1–5), which exhibited remarkable activity against the phytopathogenic fungi assayed. Their structures were established by means of spectroscopic and spectrometric methods, as well as comparison with reported data. Compounds 2 (carnosic acid), 4 (11‐acetoxy carnosic acid) and 5 (11,12‐diacetoxy carnosic acid) showed significant mycelium growth inhibition (%GI > 50 at 0.1 mg/mL concentration) on all the assayed fungi, and with a potency also higher than the positive control, Fosbel‐Plus, a fungicide commonly used in agriculture. A preliminary structure–activity relationship is also discussed.ConclusionsThese findings underline the aromatic abietane diterpenoids as promising eco‐friendly alternatives to conventional fungicides to use in integrated pest management. © 2024 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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“…For example, flavonoid luteolin and carnosic acid inhibits NETs production by inhibiting the Raf1-MEK-1-Erk pathway and ROS production. 130,131 Salvianolic acid B and 15,16-dihydrotanshinone I in Salvia miltiorrhiza significantly inhibit the formation of early NETs by inhibiting the activity of MPO and NADPH oxidase, respectively. 132 The main components of the Xuebijing Injection (Approved No.…”

Section: Inhibition Strategies Of Netsmentioning

confidence: 99%

Role and Therapeutic Targeting Strategies of Neutrophil Extracellular Traps in Inflammation

Li,

Xiao,

Filipczak

et al. 2023

IJN

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Neutrophil extracellular traps (NETs) are large DNA reticular structures secreted by neutrophils and decorated with histones and antimicrobial proteins. As a key mechanism for neutrophils to resist microbial invasion, NETs play an important role in the killing of microorganisms (bacteria, fungi, and viruses). Although NETs are mostly known for mediating microbial killing, increasing evidence suggests that excessive NETs induced by stimulation of physical and chemical components, microorganisms, and pathological factors can exacerbate inflammation and organ damage. This review summarizes the induction and role of NETs in inflammation and focuses on the strategies of inhibiting NETosis and the mechanisms involved in pathogen evasion of NETs. Furthermore, herbal medicine inhibitors and nanodelivery strategies improve the efficiency of inhibition of excessive levels of NETs.

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Carnosic acid inhibits reactive oxygen species-dependent neutrophil extracellular trap formation and ameliorates acute respiratory distress syndrome

Cited by 11 publications

References 54 publications

Targeting formyl peptide receptor 1 with anteiso‐C13‐surfactin for neutrophil‐dominant acute respiratory distress syndrome

Targeting formyl peptide receptor 1 with anteiso‐C13‐surfactin for neutrophil‐dominant acute respiratory distress syndrome

Bio‐guided isolation of aromatic abietane diterpenoids from Salvia canariensis as biopesticides in the control of phytopathogenic fungi

Role and Therapeutic Targeting Strategies of Neutrophil Extracellular Traps in Inflammation

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