Carnosic acid inhibits secretion of allergic inflammatory mediators in IgE-activated mast cells via direct regulation of Syk activation

Crozier, Robert W.E.; Yousef, Michael; Coish, Jeremia M.; Fajardo, Val A.; Tsiani, Evangelia; MacNeil, Adam J.

doi:10.1016/j.jbc.2022.102867

Cited by 8 publications

(4 citation statements)

References 53 publications

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“…In both RBL-2H3 and bone marrow-derived mast cells, FcεRI cross-linking was reported to stimulate the rapid release of intracellular ROS, including hydrogen peroxide, that is, an oxidative burst [ 31 ]. Carnosic acid, a major polyphenol in rosemary, has been reported to reduce the production of ROS and inhibit the degranulation of bone marrow-derived mast cells [ 32 ]. Therefore, one possible mechanism is that antioxidants, such as the polyphenols in the Cyclopia extracts, scavenged ROS in the RBL-2H3 cells.…”

Section: Discussionmentioning

confidence: 99%

Anti-allergic effect of <i>Cyclopia</i> (honeybush) extracts via anti-degranulation activity in a murine allergy model for inhaled antigen

SHIMBO,

FUKAGAWA,

NAKAMURA

et al. 2024

Bioscience of Microbiota, Food and Health

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The anti-allergic effects of extracts prepared from two species of honeybush, Cyclopia genistoides and C. subternata, were demonstrated in vivo in a murine allergy model for inhaled antigen induced with ovalbumin (OVA) inhalation to mimic pollen allergy. Intake of the extracts increased the production of OVA-specific immunoglobulin (Ig) E (IgE), IgG1, and IgG2a antibodies in serum and significantly suppressed anaphylactic reactioninduced body temperature decline. Moreover, the extracts significantly inhibited antigenantibody-induced degranulation in RBL-2H3 cells. They also inhibited body temperature decline when the allergic mice were given them after antigen sensitization, indicating that anti-degranulation activity is the major mechanism underlying the anti-allergic effect of Cyclopia extracts. Despite their qualitative and quantitative differences in phenolic composition, the two extracts exhibited similar effects, suggesting that several active compounds might be involved in the activity. Therefore, oral administration of either Cyclopia extract potentially exerts a systemic anti-allergic effect, supporting the increased consumption of honeybush tea for general wellness and improved quality of life.

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Section: Discussionmentioning

confidence: 99%

Anti-allergic effect of <i>Cyclopia</i> (honeybush) extracts via anti-degranulation activity in a murine allergy model for inhaled antigen

SHIMBO,

FUKAGAWA,

NAKAMURA

et al. 2024

Bioscience of Microbiota, Food and Health

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“…Furthermore, polyphenols have been found to effectively inhibit the signaling cascades of both FcεRI-mediated protein kinases (Syk, Lyn, PLCγ, PKC) and the MAPK and the NF-κB signaling pathways, which play a crucial role in allergic reactions. This, in turn, reduces the production of pro-inflammatory cytokines (IL-4 and TNF-α) and lipid mediators (prostaglandin D2 and leukotrienes) [ 215 , 216 , 217 ]. Honey from bamboo and rubber trees, which are rich in polyphenols, showed an inhibitory effect on mast cell activation and degranulation, confirming the anti-allergic potential of stingless bee honey according to research [ 218 ].…”

Section: Possible Modes Of Action For Treating or Preventing Allergy-...mentioning

confidence: 99%

Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review

Farhan,

Rizvi,

Aatif

et al. 2024

Pharmaceuticals

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Given the ongoing rise in the occurrence of allergic disorders, alterations in dietary patterns have been proposed as a possible factor contributing to the emergence and progression of these conditions. Currently, there is a significant focus on the development of dietary therapies that utilize natural compounds possessing anti-allergy properties. Dietary polyphenols and plant metabolites have been intensively researched due to their well-documented anti-inflammatory, antioxidant, and immunomodulatory characteristics, making them one of the most prominent natural bioactive chemicals. This study seeks to discuss the in-depth mechanisms by which these molecules may exert anti-allergic effects, namely through their capacity to diminish the allergenicity of proteins, modulate immune responses, and modify the composition of the gut microbiota. However, further investigation is required to fully understand these effects. This paper examines the existing evidence from experimental and clinical studies that supports the idea that different polyphenols, such as catechins, resveratrol, curcumin, quercetin, and others, can reduce allergic inflammation, relieve symptoms of food allergy, asthma, atopic dermatitis, and allergic rhinitis, and prevent the progression of the allergic immune response. In summary, dietary polyphenols and plant metabolites possess significant anti-allergic properties and can be utilized for developing both preventative and therapeutic strategies for targeting allergic conditions. The paper also discusses the constraints in investigating and broad usage of polyphenols, as well as potential avenues for future research.

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“…Indeed, these phenolic compounds, along with curcumin, EGCG, rosmarinic acid, and resveratrol, exhibited pronounced inhibitory effects on the release of histamine and β-hexosaminidase, which are used as markers to evaluate the level of mast cell degranulation [104,107,141,144,[146][147][148][149][150][151]. In addition, polyphenols have been reported as potent suppressor of both FcεRI mediated protein kinases (Syk, Lyn, PLCγ, PKC) signaling cascade and the MAPK and the NF-κB signaling pathway that are critical for the allergic reaction, resulting in attenuating secretion of pro-inflammatory cytokines (IL-4, TNF-α) in and synthesis of lipid mediators (prostaglandin D2, leukotrienes) [144,146,149,150,[152][153][154]. Interestingly, Yong et al confirmed the anti-allergic potential of stingless bee honey (Kelulut honey) in terms of mast cell activation and degranulation; however, the inhibitory effect was strictly dependent on the botanical source of honey as it was only indicated in the case of rich in polyphenols honey obtained from bamboo and rubber trees, while honey poorer in polyphenols sourced from noni and mango did not show such anti-allergic action [155].…”

Section: Effector Phasementioning

confidence: 99%

Dietary Polyphenols—Natural Bioactive Compounds with Potential for Preventing and Treating Some Allergic Conditions

Dębińska,

Sozańska

2023

Nutrients

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In light of the constantly increasing prevalence of allergic diseases, changes in dietary patterns have been suggested as a plausible environmental explanation for the development and progression of these diseases. Nowadays, much attention has been paid to the development of dietary interventions using natural substances with anti-allergy activities. In this respect, dietary polyphenols have been studied extensively as one of the most prominent natural bioactive compounds with well-documented anti-inflammatory, antioxidant, and immunomodulatory properties. This review aims to discuss the mechanisms underlying the potential anti-allergic actions of polyphenols related to their ability to reduce protein allergenicity, regulate immune response, and gut microbiome modification; however, these issues need to be elucidated in detail. This paper reviews the current evidence from experimental and clinical studies confirming that various polyphenols such as quercetin, curcumin, resveratrol, catechins, and many others could attenuate allergic inflammation, alleviate the symptoms of food allergy, asthma, and allergic rhinitis, and prevent the development of allergic immune response. Conclusively, dietary polyphenols are endowed with great anti-allergic potential and therefore could be used either for preventive approaches or therapeutic interventions in relation to allergic diseases. Limitations in studying and widespread use of polyphenols as well as future research directions are also discussed.

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Carnosic acid inhibits secretion of allergic inflammatory mediators in IgE-activated mast cells via direct regulation of Syk activation

Cited by 8 publications

References 53 publications

Anti-allergic effect of <i>Cyclopia</i> (honeybush) extracts via anti-degranulation activity in a murine allergy model for inhaled antigen

Anti-allergic effect of <i>Cyclopia</i> (honeybush) extracts via anti-degranulation activity in a murine allergy model for inhaled antigen

Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review

Dietary Polyphenols—Natural Bioactive Compounds with Potential for Preventing and Treating Some Allergic Conditions

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