Carnosine, a precursor of histidine, ameliorates pentylenetetrazole-induced kindled seizures in rat

Xiao, Wei; Ding, Mei; Zhu-Ge, Zheng Bing; Zhu, Yujun; Jin, Chun lei; Chen, Zhong

doi:10.1016/j.neulet.2006.02.031

Cited by 39 publications

(23 citation statements)

References 25 publications

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“…The an imals were observed for 60 min after PTZ administration, and seizure stage, latency to the first minimal clonic seizure (MCS), latency to the first generalized tonic-clonic seizure (GTCS), and mortality rate were recorded [23] .…”

Section: Acute Pentylenetetrazol E-induced Seizure Model In Adult Ratsmentioning

confidence: 99%

Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures

Dai

Feng

et al. 2014

Neurosci. Bull.

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Section: Acute Pentylenetetrazol E-induced Seizure Model In Adult Ratsmentioning

confidence: 99%

Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures

Dai

Feng

et al. 2014

Neurosci. Bull.

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“…[12] Pentylenetetrazole (PTZ) administration is a commonly preferred behavioral approach used for studying brain excitability [13] and for developing AEDs. [14] Chemical kindling seizures induced with PTZ are human absence epilepsy and myclonic, generalized tonic-clonic (primary generalized) seizure models [15] and it is a model for drug resistant epilepsy. [16] Kindling became one of the most important epilepsy model used for investigating neurochemical and long term structural changes in the brain.…”

Section: Kindling Modelmentioning

confidence: 99%

Pentylenetetrazol Kindling Epilepsy Model

Erkeç¹,

Arıhan²

2015

Epilepsi

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SummaryEpilepsy is one of the most common neurologic disorders affecting approximately 1% of the general population, and no alleviation was achieved in one third of the patients medicated with antiepileptic drugs. Current treatments of epilepsy are symptomatic and have more anti-seizure effects than antiepileptic effects. These therapies do not cure epilepsy. Basic mechanisms of epilepsy have not entirely been clarified yet. Using seizure and epilepsy animal models, our comprehension about basic mechanisms underlying epileptogenesis has improved. In addition, animal models of epilepsy and seizures are very useful in the discovery and development of new antiepileptic drugs. Pentylenetetrazole (PTZ) is widely used in antiepileptic drug discovery studies, and PTZ kindling model is very important to understand the pathophysiology of epilepsy. In this review, current information about PTZ kindling model was given in this aspect.Key words: Chemical kindling; epilepsy; experimental animal models; pentylenetetrazole; rat. ÖzetEpilepsi genel popülasyonun yaklaşık %1'ini etkileyen en yaygın nörolojik düzensizliklerden biridir. Antiepileptik ilaç tedavisi gören hastaların üçte birinde hiçbir hafifleme elde edilememektedir. Epilepsi için kullanılan güncel tedaviler semptomatiktir ve antiepileptik etkiden ziyade anti nöbet etkilidir. Bu tedaviler epilepsiyi tedavi etmemektedir. Epilepsinin temel mekanizmaları da henüz tam olarak anlaşılamamıştır. Nö-bet ve epilepsi hayvan modelleri kullanılarak epilepsinin temelinde yatan mekanizmaları kavrayışımız ilerlemektedir. Ayrıca epilepsi ve nöbet hayvan modelleri yeni antiepileptik ilaç keşfi ve gelişimi bakımından kullanışlıdırlar. Pentilentetrazol (PTZ), antiepileptik ilaç keşif çalışmala-rında yaygın biçimde kullanılmaktadır ve PTZ tutuşma modeli epilepsinin patofizyolojisinin anlaşılması bakımından oldukça önemlidir. Bu

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“…Ratio of paired-pulse evoked PS (%) using i.p. doses of 200~1500 mg/kg (Jin et al, 2005;Wu et al, 2006;Zhu et al, 2007). Since carnosine can penetrate blood-brain barrier easily (Crush, 1970), the corresponding concentrations in the brain of these i.p.…”

Section: Fig4 Effects Of Carnosine and Ptx On The Paired-pulse Deprementioning

confidence: 99%

“…Because it can penetrate the blood-brain barrier (BBB) easily and has few side effects, the therapeutic potentials of carnosine to some brain disorders have attracted great attention. Recent investigations have shown that carnosine has inhibitory effects on both electric stimulation-kindled seizures and chemically-induced seizures (Jin et al, 2005;Wu et al, 2006;Zhu et al, 2007). It suggests that carnosine may be used as a new anticonvulsant to treat epilepsy.…”

Section: Introductionmentioning

confidence: 99%

“…For example, carnosine can significantly decrease the glutamate release in some brain regions, such as the amygdala and hippocampus (Jin et al, 2005;Shen et al, 2007). It can also decrease the seizure duration and prolong the seizure latency (Jin et al, 2005;Wu et al, 2006;Zhu et al, 2007). However, other literatures have reported excitatory effects of carnosine on neuron activity.…”

Section: Introductionmentioning

confidence: 99%

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Effects of carnosine on the evoked potentials in hippocampal CA1 region

Feng

Zheng

Wang

2009

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To directly examine the effects of carnosine on neuronal excitation and inhibition in rat hippocampus in vivo. Methods: Artificial cerebrospinal fluid with carnosine was directly administrated over the exposed rat hippocampus. The changes of neuron activity in the CA1 region of hippocampus were evaluated by orthodromically-and antidromically-evoked potentials, as well as paired-pulse stimulation paradigm. Results: In both orthodromic and antidromic response potentials, carnosine transformed population spikes (PSs) with single spike into epileptiform multiple spikes. In addition, similar to the effect of γ-aminobutyric acid A (GABA A ) antagonist picrotoxin, carnosine decreased paired-pulse stimulating depression significantly.However, no significant change was observed in the spontaneous field potentials during the application of carnosine. Conclusion:The results indicate a disinhibition-induced excitation effect of carnosine on the CA1 pyramidal neurons. It provides important information against the application of carnosine as a potential anticonvulsant in clinical treatment.

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Carnosine, a precursor of histidine, ameliorates pentylenetetrazole-induced kindled seizures in rat

Cited by 39 publications

References 25 publications

Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures

Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures

Pentylenetetrazol Kindling Epilepsy Model

Effects of carnosine on the evoked potentials in hippocampal CA1 region

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