Carnosine may reduce lung injury caused by radiation therapy

Güney, Yıldız; Turkcu, Ummuhani Ozel; Hiçsönmez, A; Andrieu, Meltem Nalca; Güney, H. Zafer; Bi̇lgi̇han, Ayşe; Kurtman, Cengiz

doi:10.1016/j.mehy.2005.11.023

Cited by 44 publications

(26 citation statements)

References 21 publications

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“…One example is carnosine-mediated protection from lung injury caused by radiation (Guney et al 2006). In general, ionizing radiation is still a highly effective therapeutic tool for different types of cancer and is, therefore, frequently employed.…”

Section: Positive Side Effectsmentioning

confidence: 99%

“…Since formation of ROS is one of the major reasons for cellular injury after radiation (Riley 1994), carnosine may protect healthy tissue from damage and inflammation due to its antioxidant (Babizhayev et al 1994;Chan et al 1994) or anti-inflammatory properties [for a review see (Nagai 1980)]. The hypothesis of Guney et al (2006) has not been tested in humans, but 20 years ago Severin et al (1990) reported that carnosine administered per os (50-200 mg/kg/day) during a period of 20 days prior to irradiation increased survival rates in albino mice subjected to whole-body X-irradiation (5.0 Gy). Comparable experiments were performed by Kurella et al (1991) with an intake of a single dose of carnosine (50-100 mg/kg body weight).…”

Section: Positive Side Effectsmentioning

confidence: 99%

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Carnosine and cancer: a perspective

Gaunitz

Hipkiss

2012

Amino Acids

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The application of carnosine in medicine has been discussed since several years, but many claims of therapeutic effects have not been substantiated by rigorous experimental examination. In the present perspective, a possible use of carnosine as an anti-neoplastic therapeutic, especially for the treatment of malignant brain tumours such as glioblastoma is discussed. Possible mechanisms by which carnosine may perform its anti-tumourigenic effects are outlined and its expected bioavailability and possible negative and positive side effects are considered. Finally, alternative strategies are examined such as treatment with other dipeptides or b-alanine.

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Section: Positive Side Effectsmentioning

confidence: 99%

Section: Positive Side Effectsmentioning

confidence: 99%

Carnosine and cancer: a perspective

Gaunitz

Hipkiss

2012

Amino Acids

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“…In contrast, in patients with type 2 diabetes with microvascular complications a significant reduction of carnosine in skeletal muscles has been reported, while this reduction remains absent in patients with type 1 diabetes [32]. Multiple studies confirmed the hypertensive and antihypertensive effect of carnosine [33,34] and the induction of Ca 2+ release [35]. Considering this vascular effect, we hypothesize that sufficient carnosine storage might result in the prevention of micro vascular complications of diabetes, related to oxidative injury.…”

Section: Introductionmentioning

confidence: 86%

Tissue Storage of Dipeptides as Protein Guards Against Oxidative Injury in Patients with Type 2 Diabetes and Its Microvascular Complications

Heer

2015

ICPJL

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Histidine-containing dipeptides such as carnosine (β-alanine-L-histidine) and anserine (β-alanine-L-methyl histidine) are not incorporated into proteins; instead, they are stored in peripheral skeletal muscle and other organs, including the kidney, retina, and myocardium. Carnosine has several protective functions in health and disease state. This mini review provides a current overview of the knowledge of the histidine containing dipeptides in disease accompanied by oxidative stress like diabetes and diabetic microvascular complications. It also highlights the performed experimental studies of histidine-containing dipeptides in relation to tissue damage related to (non-invasive) human studies. Finally, it describes future perspectives of the therapeutic use of histidine-containing dipeptides in health and disease.

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“…Carnosine scavenges both reactive oxygen and nitrogen, which contain unpaired electrons [30,31]. Carnosine may inhibit lipid oxidation through a combination of free radical scavenging and metal chelation.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Carnosine: A Possible Drug for Vascular Dementia

Kawahara¹

2014

J Vasc Med Surg

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Carnosine (β-alanyl histidine) is a small dipeptide with numerous beneficial effects, including the maintenance of the acid-base balance, antioxidant, chelating, anti-crosslinking, and anti-glycation activities in the living organism. High levels of carnosine are found in the skeletal muscles and in the brain. We have found that carnosine inhibits Zn2+-induced neuronal death, which plays acrucial role in the pathogenesis of vascular dementia. Our previous research demonstrated that carnosine participates in the Endoplasmic Reticulum (ER)-stress pathway in Zninduced neurotoxicity and we have applied for a patent related to drugs for Vascular Dementia (VD). Here, we review the roles of carnosine in VD and otherneuro degenerative diseases and discuss perspectives about the future therapeutic use ofthis dipeptide.

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Carnosine may reduce lung injury caused by radiation therapy

Cited by 44 publications

References 21 publications

Carnosine and cancer: a perspective

Carnosine and cancer: a perspective

Tissue Storage of Dipeptides as Protein Guards Against Oxidative Injury in Patients with Type 2 Diabetes and Its Microvascular Complications

Carnosine: A Possible Drug for Vascular Dementia

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