Carnosine prevents activation of free-radical lipid oxidation during stress

Gulyaeva, N. V.; Дупин, А. М.; Levshina, I. P.; Obidin, A. B.; Boldyrev, A. A.

doi:10.1007/bf00833785

Cited by 12 publications

(10 citation statements)

References 5 publications

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“…In the present study, carnosine also inhibited glycogenolysis at 24 h postmortem. Slaughter stress cause degradation of muscle glycogen, while carnosine inhibit glycolysis and reduce stress (Gulyaeva et al., 1989). Certain stress proteins have been suggested to mediate the benefits of carnosine, such as Hsp72, which stimulates synthesis of the stress hormone corticosterone and so on (Odashima et al., 2002, 2006; Mikami et al., 2006; Wada et al., 2006).…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation with carnosine improves antioxidant capacity and meat quality of finishing pigs

Jiang

Lin

et al. 2010

Journal of Animal Physiology and Animal Nutrition

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This study was conducted to determine the effect of dietary carnosine (β-alanyl-L-histidine) supplementation on antioxidant capacity and meat quality of pigs. 72 pigs approximately 60 kg were fed a corn- and soybean meal-based diet supplemented with 0, 25, 50 or 100 mg carnosine per kg diet for 8 weeks. Carnosine supplementation did not affect growth performance and carcass traits of pigs. However, the addition of 100 mg carnosine per kg diet increased pH value of muscle at 45 min, 24 h and 48 h postmortem. It also decreased drip loss at 48 h postmortem and increased redness value of muscle at 45 min postmortem (p < 0.05). The addition of 100 mg carnosine per kg diet enhanced glycogen concentration and Ca-ATPase activity at 24 and 48 h postmortem, and reduced malondialdehyde and carbonyl protein complexes concentrations in muscle at 24 h postmortem (p < 0.05). The addition of 100 mg carnosine per kg diet increased glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) activities in plasma, liver or muscle, as well as SOD and GSH-Px genes expression in muscle (p < 0.05). Taken together, these findings indicate that carnosine supplementation improves antioxidant capacity and meat quality of pigs.

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Section: Discussionmentioning

confidence: 99%

Dietary supplementation with carnosine improves antioxidant capacity and meat quality of finishing pigs

Jiang

Lin

et al. 2010

Journal of Animal Physiology and Animal Nutrition

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“…In addition, stress can significantly increase the activity of chemical mutagens in rodents (12). The possible reasons for the mutagenic activity of stress are a genotoxic action of endogenous factors (13,14) and an increased level of lipid peroxidation (15,16). The latter explanation is supported by data from Armenia showing an increased level of lipid peroxidation in victims of the same earthquake (17).…”

Section: Discussionmentioning

confidence: 89%

Chromosome aberrations in lymphocytes of persons exposed to an earthquake in Armenia

Nersesyan

Boffetta²,

Sarkisyan³

et al. 2001

Scand J Work Environ Health

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Objective This study attempted to determine the level of chromosome aberrations in lymphocytes of victims of the 1988 earthquake in Armenia. Methods Chromosome aberrations were measured in blood samples taken from 41 victims of the earthquake that hit Armenia in 1988 and in samples of 47 reference blood donors. The victims suffered from severe psychoemotional stress but were otherwise healthy. All the samples were taken 2 to 3 weeks after the earthquake. All the subjects were lifetime nonsmokers. The cells were scored blind as to the exposure status. Results The subjects exposed to the earthquake had a higher proportion of cells with chromosome aberrations [3.1 (SD 2.1)%] than the referents [1.7 (SD 1.3)%, P-value for the difference 0.0009]. The difference persisted when the values were adjusted for age and gender [relative risk (RR) 1.9, 95% confidence interval (95% CI) 1.4-2.5]. The difference was present for double breaks (RR 4.1, 95% CI 2.6-6.4), but not for single breaks (RR 1.1, 95% CI 0.8-1.7). The exposed subjects also had a lower percentage of cells with 46 chromosomes (P=0.03) than the referents. Conclusions This study suggests an increase in chromosome aberrations in the lymphocytes of victims of a severe earthquake as compared with the levels of referents. If not due to bias or confounding, the difference may reflect the effect of either environmental exposures related to the earthquake or severe psychogenic stress. The levels of chromosome aberrations found among the earthquake victims in this study are comparable with those found in prospective studies of long-term cancer risk.

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“…In animal studies, administration of high doses of carnosine reduced oxidative damage in the brain and blood during periods of high stress 22 . For example, carnosine has excellent antioxidant properties.…”

Section: Carnosinementioning

confidence: 98%

Nutritional Supplements and Metabolic Syndrome

Mendelson¹

2008

Metabolic Syndrome and Psychiatric Illness

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Carnosine prevents activation of free-radical lipid oxidation during stress

Cited by 12 publications

References 5 publications

Dietary supplementation with carnosine improves antioxidant capacity and meat quality of finishing pigs

Dietary supplementation with carnosine improves antioxidant capacity and meat quality of finishing pigs

Chromosome aberrations in lymphocytes of persons exposed to an earthquake in Armenia

Nutritional Supplements and Metabolic Syndrome

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