2018
DOI: 10.1007/s00726-018-2676-6
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Carnosine protects cardiac myocytes against lipid peroxidation products

Abstract: Endogenous histidyl dipeptides such as carnosine (β-alanine-L-histidine) form conjugates with lipid peroxidation products such as 4-hydroxy-trans-2-nonenal (HNE and acrolein), chelate metals, and protect against myocardial ischemic injury. Nevertheless, it is unclear whether these peptides protect against cardiac injury by directly reacting with lipid peroxidation products. Hence, to examine whether changes in the structure of carnosine could affect its aldehyde reactivity and metal chelating ability, we synth… Show more

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Cited by 64 publications
(52 citation statements)
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“…Because carnosine is not synthesized in the proliferating basal cells, it seems unlikely that Carns1-deficiency directly affects these cells, especially in view of the normal level of Pax6 positive precursor cells in Carns1(-/-) OE. A property of carnosine that could potentially support survival of ORN, is of course the general anti-oxidant activity that has been demonstrated in various studies (25,(49)(50)(51). Though the in vivo anti-oxidative activity of carnosine has been questioned by others (52).…”
Section: Discussionmentioning
confidence: 99%
“…Because carnosine is not synthesized in the proliferating basal cells, it seems unlikely that Carns1-deficiency directly affects these cells, especially in view of the normal level of Pax6 positive precursor cells in Carns1(-/-) OE. A property of carnosine that could potentially support survival of ORN, is of course the general anti-oxidant activity that has been demonstrated in various studies (25,(49)(50)(51). Though the in vivo anti-oxidative activity of carnosine has been questioned by others (52).…”
Section: Discussionmentioning
confidence: 99%
“…It acts as a protective agent for contracting muscles and cardiomyocytes and is, therefore, suggested as a possible supplement in patients with HF. 35 Sialic acid is the common name for compounds derived from neuraminic acid, and it occurs mainly at terminal positions of glycoproteins (sialylation). Sialic acid has been well described in studies of cardiovascular disease as a marker of systemic inflammation and is a predictor of mortality.…”
Section: Changes In Metabolites Reflect Pathophysiologic Pathways Drmentioning
confidence: 99%
“…Among the naturally occurring histidyl dipeptides, carnosine is the most abundant in the human skeletal muscle, whereas its natural analogs such as anserine (β-alanine-N-π-histidine) and balenine (β-alanine-N-τ histidine) are found in other avian and mammalian species (Boldyrev et al, 2013). These dipeptides are multifunctional which have the capacities to chelate transition metals, such as Cu 2+ and Fe 2+ , sequester lipid peroxidation products, such as 4-hydroxy trans -2-nonenal (HNE), act as antioxidants, and buffer intracellular pH (Hipkiss, 2009; Baba et al, 2013; Boldyrev et al, 2013; Zhao et al, 2018; Ihara et al, 2019). In mammalian tissues, carnosine synthesis is catalyzed by the ATP ligase enzyme – carnosine synthetase (ATPGD1) (Drozak et al, 2010), and its homeostasis within the muscle is maintained by a complex interplay between transporters (PHT, PEPT2, and TAUT) (Everaert et al, 2013a) and hydrolases (CNDP1 and 2) (Teufel et al, 2003).…”
Section: Introductionmentioning
confidence: 99%