Carob attenuates nicotine‐induced oxidative stress and intratesticular damage in male rats

Abstract

Infertility is a social health problem that affects approximately 1/7 of the population in the reproductive age worldwide and can cause financial and emotional stress (Sarac & Koc, 2018). Semen pathologies and male-related factors appear in about half of the couples who have infertility (Aston, Krausz, Laface, Ruiz-Castane, & Carrell, 2010). Negative effects of the diet, lifestyle, environmental factors, medications and chronic exposure to toxic substances in individuals with infertility have been reported in public health studies (Gabrielsen & Tanrikut, 2016). Smoking and nicotine exposure is a common social habit that can cause serious health problems. Nicotine is a primary component that causes smoking addiction. It is promptly absorbed in the respiratory tract mucosa and its level rises rapidly in the blood circulation and the brain (Motaghinejad, Motevalian, Fatima, Faraji, & Mozaffari, 2017). In addition to being involved in the aetiology of cardiovascular diseases and cancer, nicotine has been shown to have negative effects on genetic, immunological and reproductive health. It is thought that these negative effects are caused by disruption in oxidant-antioxidant balance (Saad, Rjeibi, Brahmi, Elaloui, & Zouari, 2019). It also has been emphasised that the disruption of antioxidant defence

The effect of Cornus mas extract on nicotine-ınduced oxidative stress and intratesticular damage in male rats

“…The control group (n=6) received 0.9% saline subcutaneously once a day. The Nicotine group (n=7) received 4 mg/kg subcutaneous nicotine injections once a day (19). Cornus Mas group (n=7) was administered 1000 mg/kg Cornus mas extract in 0.5 ml saline was given via gavage (20).…”