The Middle east and North Africa harbour many native species with pharmaceutical
and nutraceutical potential. Since the beginning of history, food and herbal medicinal plants have
been an essential part of human lives and the traditional Middle Eastern healthcare system. The
notable medicinal plants that have been mentioned in the Bible, which are common in West Asia
and some regions of North Africa, are Aloe vera, anise, balm, cassia, cinnamon, cumin, flax, and
fig. Chemical components of Aloe vera are aloin, sinapinic acid, catechin, chromone, myricetin,
quercitrin and syringic acid. Anethole, safrole, and estragole are the main chemical components of
anise. The chemical components of cassia are coumarin, emodin, cinnamyl alcohol, and cinnamaldehyde.
The major chemical ingredients of cumin are terpinene, cuminaldehyde, sabinene,
thujene, and thymoquinone. The goal of this article is to review the considerable health benefits
and pharmaceutical benefits of medicinal herbs and plants that have been neglected and underutilized
in the Middle East and North Africa, as well as to promote their utilization. On the basis of
the results, the experimented neglected medicinal plant can offer various advantages when used together
with conventional medicinal treatments for various health conditions, such as palliative
care in managing the side effects of conventional treatments, access to a wider range of treatments,
increased patient satisfaction, and improved emotional and mental well-being. Moreover-,
consuming medicinal plants may help to manage and prevent diabetes, cancer, and heart disease
with notable anti-tumor, and anti-inflammatory properties.