Carotenoid lutein protects rats from paracetamol-, carbon tetrachloride- and ethanol-induced hepatic damage

Sindhu, Edakkadath Raghavan; Firdous, A P; Preethi, Korengath Chandran; Kuttan, Ramadasan

doi:10.1111/j.2042-7158.2010.01123.x

Cited by 60 publications

(45 citation statements)

References 37 publications

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“…Interestingly, it was reported that dietary lutein (50 mg/kg diet) reduced hepatic lipid peroxidation in turkeys injected with lipopolysccharides (LPS) without affecting lipid peroxidation in those with no LPS injection, suggesting that dietary lutein (50 mg lutein/kg of diet) has an antioxidant ability for oxidative damage under stressful conditions in poultry (Shanmugasundaram and Selvaraj, 2011). Similarly, a study with rats reported that antioxidant enzymes including SOD and GPX were found to be enhanced in lutein-supplemented rats compared with control group when hepatic damage was induced by alcohol and CCL4 (Sindhu et al, 2010a). In view of oxidative stress, another possible reason for increased SOD activity in the LUT group was that the dietary matrix of safflower oil containing high level of unsaturated fatty acids, which was used for dissolving a commercial lutein might produce free radicals to activate SOD for the protection from oxidative reaction.…”

Section: Discussionmentioning

confidence: 89%

Effects of Dietary Lutein Sources on Lutein-Enriched Egg Production and Hepatic Antioxidant System in Laying Hens

Jang

Kang

et al. 2014

J. Poult. Sci.

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The present study was conducted to investigate the effects of two dietary lutein sources such as the commercial lutein and the emulsified crude extract of spinach containing lutein on the transfer of lutein into egg yolks as well as the antioxidant defense system in the liver of laying hens. A total of thirty-six, 24-week-old White leghorn hens were randomly assigned to a basal diet (CON) and that supplemented with a commercial lutein (LUT, 40 mg lutein /kg of diet) and the crude extract of spinach dissolved into oils with lecithin (ECE, 40 mg lutein/kg of diet) for 5 weeks. There was no difference in body weight and the relative live weight among dietary groups. The concentration of egg yolk lutein and yolk color significantly increased (P＜0.05) in the LUT and ECE groups compared with the CON group. The LUT group showed a higher yolk lutein and much a lower variability of average yolk lutein content, although there was no significant difference in egg yolk lutein content between the LUT and ECE groups. In antioxidant activity, the specific activity of hepatic superoxide dismutase (SOD) in the LUT group was significantly (P＜0.05) greater than that in the CON and ECE groups, whereas glutathione peroxidase (GPX) and glutathione Stransferase (GST) activities and lipid peroxidation were not affected by dietary sources of lutein. In conclusion, the dietary supplementation of lutein and the emulsified crude extract of spinach to laying hens resulted in a significant increase in the content of egg yolk lutein and yolk color, indicating that both supplements may potentially be applicable for the production of egg-enriched lutein in laying hens. This study also suggest that a commercial lutein more consistently produces the quality of lutein-enriched eggs and improves hepatic SOD activity compared with the emulsified crude extract of spinach.

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Section: Discussionmentioning

confidence: 89%

Effects of Dietary Lutein Sources on Lutein-Enriched Egg Production and Hepatic Antioxidant System in Laying Hens

Jang

Kang

et al. 2014

J. Poult. Sci.

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“…Other triterpenes, particularly betulinic (107), oleanolic (105), ursolic (100), 3-epimaslinic (118), alphitolic (115) and euscaphic acids (114), isolated from the hairy roots of Ocimum basilicum L. have also shown to be effective antioxidants in combating against oxidative stress induced by CCl 4 in the liver of albino rats [101]. Concerning the tetraterpene group, the antioxidant properties of the tetraterpene meso-zeaxanthin (133) and lutein (132) explain also their hepatoprotective mechanism against the toxicity of oxidative stress induced not only by CCl 4 but also by paracetamol and ethanol in rats [102,103].…”

Section: Hepatoprotectionmentioning

confidence: 99%

Terpene Compounds in Nature: A Review of Their Potential Antioxidant Activity

González-Burgos

Gómez-Serranillos

2012

CMC

298

157

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Reactive Oxygen Species are involved in the pathological development of many important human diseases such as neurodegenerative diseases, cardiovascular processes, diabetes and many others. The most promising strategy to prevent from the oxidative damage caused by these reactive species is the use of antioxidant molecules. These compounds can act as direct antioxidants through free radical scavenging mechanisms and/or as indirect antioxidants by enhancing the antioxidant status (enzymatic and non-enzymatic). Terpenes, one of the most extensive and varied structural compounds occurring in nature, display a wide range of biological and pharmacological activities. Here we highlight their antioxidant properties. Due to their antioxidant behaviour terpenes have been shown to provide relevant protection under oxidative stress conditions in different diseases including liver, renal, neurodegenerative and cardiovascular diseases, cancer, diabetes as well as in ageing processes. Evidence for this comes from the increasing number of publications on this issue in recent years. This review provides a complete overview of the natural terpenes with potential antioxidant properties, focusing on their source, structures, antioxidant mechanisms through which they exert their pharmacological and possible therapeutic activities.

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“…MZ has been shown to reduce hepatotoxins in the body and to stimulate glutathione, a powerful antioxidant that can help protect liver cells, support detoxification enzymes more effectively and protect the liver from toxins, including certain drugs such as acetaminophen (Tylenol), which can cause liver damage in high doses, have antioxidant and anti-inflammatory properties, and may help the liver repair itself by growing new cells [25,40,42]. In preclinical studies, one month MZ supplementation increases antioxidant enzymes in mice [43,44]. Laboratory studies show that MZ scavenges superoxide, hydroxyl, nitric oxide and DPPH and ABTS radicals, as well as inhibits tissue lipid peroxidation in vitro in a concentration dependent manner [25].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Meso-Zeaxanthin (MZ): Current Perspectives and New Insights

Juturu¹

2014

AOVS

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Recent in vitro, in vivo and human studies indicate that dietary meso-zeaxanthin (MZ) may be of benefit in maintaining vision and provides antioxidant and anti-inflammatory support. MZ is a macular carotenoid with additional protective effects such as antioxidant, anti-mutagenic, singlet oxygen quenching and inhibitory effects on specific CYP450 isoenzymes, potential to induce phase II enzymes, chemo-protective and anti-carcinogenic effects. MZ scavenges superoxide, hydroxyl, nitric oxide diphenyl-2-picrylhydrazyl (DPPH) radical, and 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radicals, inhibits tissue lipid peroxidation and prevents cellular damage. MZ increase the levels of antioxidant enzymes like catalase, superoxide dismutase and glutathione peroxidase. MZ supplementation will provide benefit for maintaining visual performance in health and disease. Recent data strongly support the observation that adequate macular carotenoid supplementation may significantly reduce the risk of macular degeneration and age related macular degeneration mediated by reactive oxygen species. This review will focus on the effect of macular carotenoids and MZ in the context of carotenoids' unique visual health including antioxidant and anti-inflammatory properties. KeywordsMeso-zeaxanthin; Macular carotenoids; Antioxidant; Eye health Meso-Zeaxanthin (MZ): Current Perspectives and New InsightsCitation: Juturu V (2014) Meso-Zeaxanthin (MZ): Current Perspectives and New Insights. Adv Ophthalmol Vis Syst 1(2): 00010.

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Carotenoid lutein protects rats from paracetamol-, carbon tetrachloride- and ethanol-induced hepatic damage

Abstract: Histopathological evidence confirmed the protection offered by lutein from the tissue damage caused by hepatotoxins. The hepatoprotective action may be due to lutein's ability to scavenge reactive oxygen radicals.

Cited by 60 publications

References 37 publications

Effects of Dietary Lutein Sources on Lutein-Enriched Egg Production and Hepatic Antioxidant System in Laying Hens

Effects of Dietary Lutein Sources on Lutein-Enriched Egg Production and Hepatic Antioxidant System in Laying Hens

Terpene Compounds in Nature: A Review of Their Potential Antioxidant Activity

Meso-Zeaxanthin (MZ): Current Perspectives and New Insights

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