Carotenoid metabolism in mammals, including man: formation, occurrence, and function of apocarotenoids

Genetic dissection in a mouse model reveals interactions between carotenoids and lipid metabolism

“…In fact, when we removed the ability of tissues to synthesize retinoids, carotenoids had only a modest effect on the transcriptome. This is consistent with the notion that the parent carotenoids do not directly interact with transcription factors as opposed to their apocarotenoid metabolites (13). These findings strongly suggest that retinoic acid, or any other retinoic acid receptor ligand, cannot be generated in the absence of BCO1 and BCO2.…”

“…1A, insert 2). Previously, it has been reported that -apocarotenals can be formed by carotenoid-oxygenase-independent pathways (13). To test this possibility, we intended to chemically convert the metabolite to the corresponding oxime.…”

Bioavailability of Palm Oil Carotenoids Consumed from Different Foods

“…Their non-digestible character in human digestive prevents production of micelles by inhibiting digestive lipases activity and/or by binding to bile acids or to phospholipids. Fibers also increase intestinal content, viscosity and volume thereby slowing processes of diffusion of micelles on the absorbent surface of enterocytes (Yonekura & Nagao, 2007;Eroglu & Harrison, 2013). Besides, Riedl et al (1999) confirmed that dietary fibers decrease carotenoids absorption in human.…”

“…This depends on the nature and quantity of carotenoids present in food (Eroglu & Harrison, 2013). But, carotenoids composition of the test and control meals used in this study could not explain the difference observed because meals contained the same quantity of carotenoids (10 mg) per eaten portion and came from the same source which is CPO.…”

The fat-soluble vitamins 100 years later: where are we now?

“…Research carried out over the last decade has provided many new insights into questions related to carotenoid conversion to vitamin A and carotenoid metabolism to apocarotenoids. The review entitled " Carotenoid metabolism in mammals including man: formation, occurrence and function of apocarotenoids " from Eroglu and Harrison ( 16 ) in this issue will consider new research fi ndings in these areas, as well as other new fi ndings related to carotenoid actions and metabolism in higher animals.…”