Carotenoid mixtures protect multilamellar liposomes against oxidative damage: synergistic effects of lycopene and lutein

Abstract

Antioxidant activity of carotenoids in multilamellar liposomes assayed by inhibition of formation of thiobarbituric acid-reactive substances was in the ranking:Mixtures of carotenoids were more effective than the single compounds. This synergistic effect was most pronounced when lycopene or lutein was present. The superior protection of mixtures may be related to specific positioning of different carotenoids in membranes.z 1998 Federation of European Biochemical Societies.

A Comparative Study of Antioxidant Activities between Fresh and Dry Mushrooms in the Genera <i>Cantharellus</i> and <i>Afrocantharellus</i> from Tanzania

“…Lycopene is known to be the most efficient singlet oxygen quencher compared with a variety of carotenoids and a-tocopherol in vitro [42]. The study by Stahl et al [43] shows that it is three times more efficient than β-carotene in preventing lipid peroxidation in multi lamellar liposomes. Lycopene has been also found to provide up to 35% protective effect against lung and prostate cancer with no associated risks [44].…”

Lycopene as a natural antioxidant

“…It is noteworthy that equimolar mixtures of carotenoids are more effective than any single compound alone. This strong synergistic effect is most pronounced with lycopene and lutein together [8].…”

“…The antioxidant activity of lycopene in multilamellar liposomes is superior to other lipophilic natural antioxidants (e.g. a-tocopherol, a-carotene, b-cryptoxanthin, zeaxanthin, b-carotene and lutein) [8]. It is noteworthy that equimolar mixtures of carotenoids are more effective than any single compound alone.…”

New Developments in Lycopene Analysis by Spectroscopic and Chromatographic Techniques, Accompanied With Mathematical Modelling

“…The scientific findings show that lycopene differentially modulates gap-junctional intercellular communication (GJIC) depending on the dose, with beneficial effects on cell communication [82,83]. Lycopene may stimulate GJC through stabilization of connexin43 mRNA [84].…”

“…When tested for antioxidant properties in a multilamellar liposome system, lycopene was found to have the greatest antioxidant activity among carotenoids; ranked from greatest to least, they were lycopene, a-tocopherol, a-carotene, b-cryptoxanthin, zeaxanthin, b-carotene, and lutein [82]. Lycopene showed a dose-responsive ability to inhibit the mutagenicity of 2-amino-1-methyl-6-phenylimidazol(4-,5-b) pyridine (PhIP) with a 50% inhibitory dose (ID50) of 271 mg of lycopene [109].…”