Carotenoids and carotenoids plus vitamin E protect against ultraviolet light–induced erythema in humans

Stahl, Wilhelm; Heinrich, Ulrike; Jungmann, H; Sies, Helmut; Tronnier, H

doi:10.1093/ajcn/71.3.795

Cited by 279 publications

(180 citation statements)

References 20 publications

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“…The evaluation of a large number of associations could cause that significant results are chance findings. Previous intervention studies showed both positive effects of supplementation of either b-carotene or a combination of carotenoids on UV sensitivity (MathewsRoth et al, 1972;Gollnick et al, 1996;Lee et al, 2000;Stahl et al, 2000) or no effect on UV sensitivity (Wolf et al, 1988;Garmyn et al, 1995). The duration of the supplementation might be an important factor.…”

Section: Discussionmentioning

confidence: 99%

“…The results of these studies were, however, inconclusive and contradictory (La Ruche and Cesarini, 1991;Werninghaus et al, 1994;Garmyn et al, 1995;Gollnick et al, 1996;Eberlein-König et al, 1998;Fuchs & Kern, 1998;Wolf et al, 1988;Lee et al, 2000;Stahl et al, 2000). Moreover, all these studies used synthetic (pure) compounds in relatively high dosages compared to the normal physiological range of vitamins and carotenoids.…”

Section: Introductionmentioning

confidence: 99%

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Determinants of skin sensitivity to solar irradiation

et al. 2003

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Background: Acute effects of UV irradiation include UV-induced erythema. Sunlight plays an important role in the development of skin cancer. Several predictive factors of UV-induced erythema could also be predictive for skin cancer. Objective: Our objective was to quantitatively assess phenotypical and nutritional determinants of sensitivity to UV irradiation, as assessed by the minimal erythema dose (MED). Design: We conducted a cross-sectional study among 335 volunteers. Sensitivity to UV irradiation was established through assessment of the MED. Phenotypical determinants, including skin melanin content, hair color and iris color were determined by skin reflectance spectrometry, a subjective questionnaire and an objective classification system, respectively. Furthermore, dietary exposure was measured by carotenoids, vitamin C, retinol and a-tocopherol in serum. Results: Male subjects were found to be more sensitive to UV irradiation; that is, the MED was significantly lower compared to female subjects. Skin melanin content, which was positively associated with iris color in both sexes and with hair color in men, was the main phenotypical determinant of sensitivity to UV irradiation. No associations were found between serum carotenoids and MED in the total study group. Vitamin C was inversely associated with MED. However, associations between carotenoids concentrations and MED showed a positive trend in subjects with melanin values above and a negative trend in subjects below the median after adjustment for gender and total cholesterol. Conclusions: Skin melanin content and gender are important determinants of sensitivity to UV irradiation. No relation was found between serum carotenoids and MED in the total study group. The inverse association between vitamin C and MED was against our hypothesis. For the modifying effect of melanin on the association between carotenoids and MED, we do not have a clear biological explanation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determinants of skin sensitivity to solar irradiation

et al. 2003

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“…Derg. 40(1): [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53]2016 Şen 39 fotohasarın şiddetiyle orantılıdır. Tip IV kollagen dermoepidermal bileşkedeki temel kollajen olup mekanik etkileşim için büyük önem taşımaktadır.…”

Section: Yaşlanma Sonucu Deride Görülen Değişikliklerunclassified

Deri yaşlanması ve antioksidanların önemi

Şen¹

2016

Ankara Üniversitesi Eczacılık Fakültesi Dergisi

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“…In addition, they exhibit antioxidant, antimutagenic, anti-inflammatory and anticarcinogenic activities. Therefore, the use of botanicals is an approach to reduce the UV-generated ROS-mediated photodamage, immune-suppression and skin cancer in patients (Katiyar et al, 2000(Katiyar et al, , 1999Morales et al, 2011;Stahl et al, 2000;Zhou et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Screening of UVA/UVB Absorption and in vitro Antioxidant Capacity of Bejaria aestuans, Cavendishia pubescens and Cavendishia bracteata Leaf Extracts

Puertas-Me¹,

Rincon-Val²,

Mejia-Gira³

2015

Research J. of Medicinal Plant

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The UV solar radiation accelerates skin aging, leading to loss of skin elasticity and decreasing the capacity of the skin to hold water, which are implicated in the formation of the most obvious sign of aging, skin wrinkling and related health problems in humans. Usually, synthetic sunscreens have been used to minimize these effects. However, some phenolic compounds present in plants play an important role as photoprotectors. The aim of this study was to explore the potential of three plants from Ericaceae family as UVA-UVB filters and its antioxidant capacity. Leaf extracts of B. aestuans, C. bracteata and C. pubescence showed an interesting broad-spectrum UVB/UVA absorption that was correlated with the antioxidant capacity (from 1.96E-04-3.75E-04 mg µmolG 1 DPPH), the TPC value (from 15.29-27.35 mg GAE gG 1 DS) and TAC value (0.36-3.31 mg C3GE gG 1 DS). According to these results, the three plants evaluated in this research could be considered as a potential source of natural compounds with UV absorption and antioxidant capacity.

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Carotenoids and carotenoids plus vitamin E protect against ultraviolet light–induced erythema in humans

Abstract: The antioxidants used in this study provided protection against erythema in humans and may be useful for diminishing sensitivity to ultraviolet light.

Cited by 279 publications

References 20 publications

Determinants of skin sensitivity to solar irradiation

Determinants of skin sensitivity to solar irradiation

Deri yaşlanması ve antioksidanların önemi

Screening of UVA/UVB Absorption and in vitro Antioxidant Capacity of Bejaria aestuans, Cavendishia pubescens and Cavendishia bracteata Leaf Extracts

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