Carotenoids as antioxidants: spin trapping EPR andoptical study

Polyakov, Nikolay E.; Kruppa, Alexander I.; Leshina, Tatyana V.; Konovalova, Tatyana A.; Kispert, Lowell D.

doi:10.1016/s0891-5849(01)00547-0

Cited by 73 publications

(53 citation statements)

References 31 publications

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“…On the other hand, a strong dependence of the rate constants on the concentration of GA was detected for carotenoid complexes. This fact is in accordance with earlier established changes of the structure of glycyrrhizin self-associates at the concentration range above 1 mM [46], and preclinical studies with the rat models [55][56].…”

Section: Activity Of Carotenoid-glycyrrhizin Complexessupporting

confidence: 92%

“…This effect might be the reason of several surprising observations of decreasing the therapeutic effect of GA complexes with some drugs with increasing GA concentration [55][56]. …”

Section: Stoichiometry and Stability Of Carotenoidglycyrrhizin Complexesmentioning

confidence: 96%

“…Such agents are able to facilitate drug delivery, to protect parent substances from metabolic decay, and to contribute to their prolonged action. For example, the complex of GA with nifedipine (NF, 1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethylester, see Scheme 1) shows significant increase in therapeutic activity on the models of adrenaline-induced hypertension and CaCl 2 induced arrhythmia [56]. In the preclinical study of nifedipine activity using the model of CaCl 2 induced arrhythmia in rats, it has been shown, that minimum therapeutic dose of NF-GA complex is 29 times lower as compared to free NF.…”

Section: Complex Of Glycyrrhizin With Nifedipinementioning

confidence: 99%

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Glycyrrhizic Acid as a Novel Drug Delivery Vector: Synergy of Drug Transport and Efficacy

Polyakov

Leshina²

2011

TOPROCJ

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Supramolecular drug delivery systems (DDS) are widely used in pharmacology during last decades for designing new preparations with improved properties. Most of fundamental and applied research in this field has been devoted to the inclusion complexes with cyclodextrins (CD), which are assumed to possess protective properties and to decrease the hydrophobic behavior of the included molecules. At present a new generation of DDS has been developing. Novel DDS are focused simultaneously on several purposes, including improved bioavailability and stability of drugs, targeted drug delivery, and enhanced activity. One of the compounds that appear to be promising is glycyrrhizic acid (or glycyrrhizin). A number of experimental facts of high therapeutic activity of glycyrrhizin conjugates have been published, but no understanding "how it works" was presented. This manuscript will highlight our attempts to answer this question using physicochemical approach, and also outline the challenges and future opportunities for medical applications of glycyrrhizin conjugates.

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Section: Activity Of Carotenoid-glycyrrhizin Complexessupporting

confidence: 92%

“…This effect might be the reason of several surprising observations of decreasing the therapeutic effect of GA complexes with some drugs with increasing GA concentration [55][56]. …”

Section: Stoichiometry and Stability Of Carotenoidglycyrrhizin Complexesmentioning

confidence: 96%

Section: Complex Of Glycyrrhizin With Nifedipinementioning

confidence: 99%

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Glycyrrhizic Acid as a Novel Drug Delivery Vector: Synergy of Drug Transport and Efficacy

Polyakov

Leshina²

2011

TOPROCJ

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“…Between these are highlighted ferulic acid (79) , carotenoids (80) , tannic acid (81) , DHB (82) , flavonoids (83) .…”

Section: Ligands Effects On Fenton Reactionmentioning

confidence: 99%

Fenton Reaction Driven by Iron Ligands

Salgado

Melín

Contreras

et al. 2013

J. Chil. Chem. Soc.

107

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One of the most important sources of reactive oxygen species (ROS) in biological systems is the Fenton reaction. In this, the Fe 2+ or Fe 3+ reacts with H 2 O 2 to produce ROS as the hydroxyl radical (•OH), superoxide radical (O 2 •-) and singlet oxygen ( 1 O 2 ). The main ROS, responsible for the high oxidizing power of the Fenton reaction, is not clear. Some authors claim that the principal reactive species is •OH, while others propose a ferryl specie (Fe 4+ or [FeO] 2+ ) (1,2) . Recently, have been proposed that the kind of reaction species produced depends mainly of pH and the iron composition of the coordination sphere. This is highlighted for Fe 3+ , because in mono and (some) bis-complexes Fe 3+ is reduced to Fe 2+ and there are some positions occupied by water or hydroxide ligands, readily to be exchanged by H 2 O 2 . On the other hand, in tris-complexes there are not any positions occupied by water or hydroxide, avoiding the formation of peroxo-complexes, necessary for Fenton or Fenton like reaction.The 1,2-dihydroxybenzenes (DHBs) have been described as modulators of Fenton reaction. The DHBs driven Fenton reaction have been used for environmental applications as an advanced oxidation process. Furthermore, these systems participate in different biological process, as the wood biodegradation by fungi and oxidative stress in neurodegenerative diseases.In this review, the effect of 1,2-dihydroxybenzenes on the activated species production by the Fenton and Fenton like reaction will be discussed and its participation in different systems.

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“…The finding that spin trapping of ROS species by carotenoids, increases with increasing carotenoid oxidation potential 14 . That decreasing scavenging rate of free radicals decreases with decreasing oxidation potential.…”

Section: Anti-oxidative Effectsmentioning

confidence: 96%

Research Progress of Astaxanthin on Contrast agent induced acute kidney injury

Li¹

2018

J Cardiol and Cardiovasc Sciences

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Contrast agent induced acute kidney injury (CI-AKI) is a leading cause of hospital-acquired acute kidney injury as a result of more and more iodinated contrast-media use for diagnostic purposes. Previous studies have demonstrated that oxidative stress and apoptosis are established processes contributing to contrast agent induced acute kidney injury. Astaxanthin (ATX), a carotenoid found in microalgae, fungi, complex plants, seafood, flamingos and quail has been confirmed have anti-oxidant, and anti-apoptosis effects. Experimental investigations in a range of species using a contrast agent induced acute kidney injury model demonstrated kidney preservation when ATX is administered prior to the induction of contrast agent. ATX, as an natural antioxidant, is capable to prevent CI-AKI effectively, and the mechanism is possibly related to anti-oxidant and anti-apoptosis. In this mini review, we briefly summarize the potential for ATX as a protector against CI-AKI pathologies.

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Carotenoids as antioxidants: spin trapping EPR andoptical study

Cited by 73 publications

References 31 publications

Glycyrrhizic Acid as a Novel Drug Delivery Vector: Synergy of Drug Transport and Efficacy

Glycyrrhizic Acid as a Novel Drug Delivery Vector: Synergy of Drug Transport and Efficacy

Fenton Reaction Driven by Iron Ligands

Research Progress of Astaxanthin on Contrast agent induced acute kidney injury

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