2012
DOI: 10.1016/j.jns.2012.07.008
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Carotid artery disease and cognitive impairment

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Cited by 44 publications
(41 citation statements)
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“…1 Given the high prevalence of vascular risk factors in these patients, we hypothesize that nonadherence to medical therapy will likely lead to increased cardiovascular morbidity, These results are consistent with other data showing that a significant percentage of patients with carotid atherosclerosis have cognitive impairment. 4 Also in agreement with prior studies is the range of abnormal MoCA values observed, which is compatible with mild cognitive impairment. 7 Previously reported rates of cognitive impairment in carotid stenosis vary according to the specific cognitive testing utilized.…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…1 Given the high prevalence of vascular risk factors in these patients, we hypothesize that nonadherence to medical therapy will likely lead to increased cardiovascular morbidity, These results are consistent with other data showing that a significant percentage of patients with carotid atherosclerosis have cognitive impairment. 4 Also in agreement with prior studies is the range of abnormal MoCA values observed, which is compatible with mild cognitive impairment. 7 Previously reported rates of cognitive impairment in carotid stenosis vary according to the specific cognitive testing utilized.…”
Section: Discussionsupporting
confidence: 91%
“…3 Carotid disease is a risk factor for cognitive impairment, with the underlying mechanism attributed to either cerebral emboli or hypoperfusion with or without silent brain infarctions. 4 We explored whether undiagnosed cognitive impairment impacts adherence to medications for vascular risk reduction in patients with asymptomatic carotid stenosis.…”
Section: A N U S C R I P Tmentioning
confidence: 99%
“…In addition, in the absence of collateral circulation, the brain is in a hypoperfusion state, which may cause ischemia in the region supplied by the deep perforating artery, inducing oxidative stress, inflammatory reaction, increased phagocytosis of oligodendrocytes, and metalloproteinase activation [20], which may reduce cognitive function. Patients with cerebral artery stenosis develop cognitive dysfunction to various degrees [21,22]. When the stenosis is improved and the perfusion increases, the cellular metabolism also improves [23].…”
Section: Discussionmentioning
confidence: 99%
“…Laboratory testing is the next step; at this stage, blood tests are used to determine the blood sugar level and cholesterol level. This step is followed by an examination of the computer tomography/magnetic resonance imaging scan and electrocardiography recording to indicate stroke location and pulse irregularity, such as cardiovascular status, carotid bruits, fundus examination, peripheral vascular disease, and hypertension 9. Electroencephalography is used to help differentiate between seizure and TIA or between lacunar and cortical infarction in occasional patients, as illustrated in Figure 2 10…”
Section: Stroke Typesmentioning
confidence: 99%