Carotid atherosclerosis and lipoprotein particle subclasses in familial hypercholesterolaemia and familial combined hyperlipidaemia

Circulating soluble low-density lipoprotein receptor-related protein 1 (sLRP1) concentration is associated with hypercholesterolemia: A new potential biomarker for atherosclerosis

“…LDL-C was estimated by the Friedewald formula, whereas ApoB, ApoA-I and C-reactive protein (CRP) were determined by nephelometry. Ultrasonographic evaluation of carotid arteries was performed as described previously [36]. In brief, common carotid, carotid bulb and internal carotid arteries were bilaterally assessed; images of each arterial segment were collected with an Acuson Sequoia 512 ultrasound scanner equipped with an 8L5 transducer (Siemens AG, Erlangen, Germany).…”

Association of USF1 and APOA5 polymorphisms with familial combined hyperlipidemia in an Italian population

“…These characteristics make FCH diagnosis particularly difficult due to its overlapping with other metabolic diseases and to the variability of its phenotype [4]. The presence of small dense LDLs (sdLDL) and increased levels of Apolipoprotein B (ApoB) [5] have been considered hallmarks of FCH, although it has been recently demonstrated that they are also common to other hyperlipidemias [5]. The genetic background of FCH is heterogeneous as it includes many genes having a different impact on the disease development [1].…”

Carotid Plaques Correlates in Patients With Familial Hypercholesterolemia

“…21,29 Patients with plaques were characterized by slightly higher values of serum apoA1 concentration. We also observed small, but significantly positive correlation between apoA1 and cIMT mean .…”