Carotid Atherosclerosis Detected by Ultrasonography: A National Cross‐Sectional Study

Wang, Xiaojun; Li, Wenzhen; Song, Fujian; Wang, Longde; Fu, Qian; Cao, Shiyi; Gan, Yong; Zhang, Wei; Yue, Wei; Yan, Feng; Shi, Wenhuan; Wang, Xiaoli; Zhang, Hong; Zhang, Hao; Wang, Zhihong; Lu, Zuxun

doi:10.1161/jaha.118.008701

Cited by 89 publications

(87 citation statements)

References 46 publications

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“…The rationale, design, and methods of the CNSSPP have previously been described in detail. 9 Our study was based on the data from the CNSSPP in 30 provinces in Mainland China conducted between October 1 st 2014 and November 30 th 2015. Briefly, a stratified, multistage random sampling method was used to obtain a nationally representative sample of the general Chinese population aged 40 years or older.…”

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confidence: 99%

Sex differences in risk factors for stroke: A nationwide survey of 700,000 Chinese Adults

Yan

Gan

et al. 2019

Eur J Prev Cardiolog

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Stroke has become a major public health concern globally. 1 The burden of stroke has increased significantly worldwide in the past two decades. The incidence of stroke has decreased in developed countries, by contrast, it has increased significantly in developing countries. 2 In China, stroke has become the first leading cause of death, and it is the most prominent factor for disability-adjusted life-years lost. 3 Epidemiological studies of sex disparity in the prevalence, incidence, and mortality of stroke and its risk factors have been conducted in Western countries; 4-8 however, no studies have focused on sex differences in the risk factors for stroke in China. With stroke becoming a great public health issue, findings on sex disparity in stroke risk factors among the Chinese adults are urgently needed to facilitate future personalized healthcare management policy and planning. Thus, we aimed to examine sex differences in the risk factors for stroke based on a nationally representative population-based sample of middle-aged and older Chinese populations.The China National Stroke Screening and Prevention Project (CNSSPP) was a key national action on stroke prevention and control launched in 2011 by the Chinese government.The rationale, design, and methods of the CNSSPP have previously been described in detail. 9Our study was based on the data from the CNSSPP in 30 provinces in Mainland China conducted between October 1 st 2014 and November 30 th 2015. Briefly, a stratified, multistage random sampling method was used to obtain a nationally representative sample of the general Chinese population aged 40 years or older.Socio-demographic characteristics, stroke history, family history of stroke, medical history, and status of risk factors were collected though trained healthcare workers with a standardized 4 questionnaire. Physical examinations included the assessment of height, weight, and blood pressure (BP) and an electrocardiogram. Laboratory examinations included the measurements of serum lipids (total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides) and fasting plasma glucose.The associations between sex and stroke related risk factors, including stroke history, hypertension, diabetes mellitus (DM), hyperlipidemia, atrial fibrillation (AF), smoking, overweight or obesity, and physical inactivity, were estimated using multivariable logistic regression analysis, respectively. We performed analyses by using SAS version 9.3, and all tests were 2-sided with a significance level of 0.05.A total of 726,451 respondents (53.27% women) with a mean age of 57.23±11.41 years were investigated in this study. The relatively young mean age among people aged 40 and over in our sample was due to the population structure in China (Figure 1). The age-standardized prevalence rate of stroke was 2.11%. The age-standardized prevalence of stroke was markedly higher in males compared to females (2.30% versus 1.94%).The sex differences in risk factors associated with stroke are show...

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confidence: 99%

Sex differences in risk factors for stroke: A nationwide survey of 700,000 Chinese Adults

Yan

Gan

et al. 2019

Eur J Prev Cardiolog

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“…According to the standard established by the CNSSPP committee [8], high-risk group of stroke were defined as follows: at least 40 years old, at least three of the following risk factors, including hypertension, atrial fibrillation, smoking, dyslipidemia, diabetes mellitus, physical inactivity, overweight or obesity (BMI ≥26 kg/m 2 ), and family history of stroke. Individuals who had the history of stroke or transient ischemic attack were also considered at high risk.…”

Section: High Risk Group Of Stroke Individualsmentioning

confidence: 99%

“…The definition of the eight risk factors adopts the unified standard of CNSSPP, which has been published in previous paper [8]. Hypertension was defined as a systolic blood pressure of 140 mmHg or more, diastolic blood pressure of 90 mmHg or more, self-reported hypertension diagnosed by a physician, or taking antihypertensive medications [9].…”

Section: High Risk Group Of Stroke Individualsmentioning

confidence: 99%

A model to predict unstable carotid plaques in population with high risk of stroke

Yin

Liu

et al. 2020

BMC Cardiovasc Disord

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Background: Several models have been developed to predict asymptomatic carotid stenosis (ACS), however these models did not pay much attention to people with lower level of stenosis (<50% or carotid plaques, especially instable carotid plaques) who might benefit from early interventions. Here, we developed a new model to predict unstable carotid plaques through systematic screening in population with high risk of stroke. Methods: Community residents who participated the China National Stroke Screening and Prevention Project (CNSSPP) were screened for their stroke risks. A total of 2841 individuals with high risk of stroke were enrolled in this study, 266 (9.4%) of them were found unstable carotid plaques. A total of 19 risk factors were included in this study. Subjects were randomly distributed into Derivation Set group or Validation Set group. According to their carotid ultrasonography records, subjects in derivation set group were further categorized into unstable plaque group or stable plaque group. Results: 174 cases and 1720 cases from Derivation Set group were categorized into unstable plaque group and stable plaque group respectively. The independent risk factors for carotid unstable plaque were: male (

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“…Results and determination: carotid intimal thickness (IMT) was measured. Normal IMT: common carotid artery or its bifurcation IMT<1.0mm; Thickening of IMT: 1.0mm≤ common carotid artery or its bifurcation IMT<1.5mm; Plaque formation: IMT≥1.5mm in any carotid artery [9]. The 2338 patients who underwent carotid ultrasound were divided into four groups: normal group, thickening group, stable plaque group and unstable plaque group.…”

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confidence: 99%

Association of ApoE Gene Polymorphisms With Cardio-cerebrovascular Complications in Type 2 Diabetes Mellitus in the Chinese Population

Kong

Gao²,

et al. 2020

Preprint

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Objective: To analyze and study the relationship between ApoE gene polymorphism and cardio-cerebrovascular complications in type 2 diabetes mellitus(T2DM) in the Chinese Population. Methods: From January 2018 to January 2019, 1140 patients with type 2 diabetes admitted to the Department of Endocrinology, the Affiliated Hospital of Xuzhou Medical University were selected as the case group, including 590 patients with coronary heart disease(CHD) and 550 patients with cerebral infarction(CI), and 1198 patients with type 2 diabetes without complications during the same period were selected as the control group. General baseline data of the two groups were collected, such as gender, age, course of disease, lipid profile, HbA1C, BMI, blood pressure, carotid plaque and complications. ApoE genotypes were identified in all participants who participated in the study.Results: This study showed that the ApoE genotypes in both the case group and the control group had the highest frequency of E3/E3. The E3/E4 genotype frequency and E4 allele frequency in the case group were higher than those in the control group (P<0.05). In the case group, the frequency of E2/E3 and E3/E4 genotypes of CI group was lower than that of CHD group, while the frequency of E3/E3 genotype was higher than that of CHD group. TC and LDL-c levels were significantly increased in patients with ApoE E3/E4 genotype(P<0.05). ApoE genotype E3/E4 was more associated with carotid plaque than E2/E3. ApoE genotype and ApoE allele were positively correlated with TC and LDL-c levels (P<0.05).Logistic regression results show that ApoE gene polymorphism is associated with cardio-cerebrovascular complications in T2DM patients. ApoE E3/E4 genotype and allele E4 may be risk factors for T2DM patients with cardio-cerebrovascular complications.Conclusion: ApoE E3/E4 genotypes and T2DM patients carrying E4 allele have a higher risk of cardio-cerebrovascular complications than other genotypes. ApoE E2 allele has a certain protective effect , however E4 allele may be a risk factor for cardio-cerebrovascular complications in T2DM patients, and its mechanism may be related to the effect of ApoE gene on lipid metabolism.

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Carotid Atherosclerosis Detected by Ultrasonography: A National Cross‐Sectional Study

Cited by 89 publications

References 46 publications

Sex differences in risk factors for stroke: A nationwide survey of 700,000 Chinese Adults

Sex differences in risk factors for stroke: A nationwide survey of 700,000 Chinese Adults

A model to predict unstable carotid plaques in population with high risk of stroke

Association of ApoE Gene Polymorphisms With Cardio-cerebrovascular Complications in Type 2 Diabetes Mellitus in the Chinese Population

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