Carotid Atherosclerosis in Ischemic Cerebrovascular Patients

Zhang, Ai Juan; Zhong, Chao

doi:10.4021/jocmr2009.03.1226

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…21 Carotid atherosclerosis can reflect cerebral atherosclerosis to some extent and is an important predictor of cerebral infarction. 22 The previous study 23 confirmed that the incidence of severe and unstable carotid atherosclerosis was higher in patients with ischemic stroke. Hyperhomocysteinemia is an independent risk factor for carotid atherosclerosis and is significantly related to the degree of carotid atherosclerosis.…”

Section: Effect Of Hyperhomocysteinemia On Carotid Atherosclerosis (Imentioning

confidence: 70%

Study of the Inflammatory Mechanisms in Hyperhomocysteinemia on Large-Artery Atherosclerosis Based on Hypersensitive C-Reactive Protein—A Study from Southern China

Guo

Zhu

2019

Journal of Stroke and Cerebrovascular Diseases

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Objective: To study the inflammatory mechanism of hyperhomocysteinemia on large-artery atherosclerosis based on hypersensitive C-reactive protein in patients. Methods: In all, 153 inpatients and 1357 physical examinees were selected. The levels of homocysteine were compared between the carotid/intracranial artery stenosis group and the nonstenosis group, between the carotid artery unstable plaque group and the nonplaque group, and between the intima-media thickness (IMT) greater than or equal to 1 group and the normal IMT group. The hypersensitive C-reactive protein levels were compared between the lacunar infarction (LI) group and the nonstroke control group and between the unstable plaque group and the nonplaque group. Results: Homocysteine level was significantly higher in the carotid/intracranial artery stenosis group than in the nonstenosis group, in the LI group than in the inpatient nonstroke group, and in the IMT greater than or equal to 1 group than in the normal IMT group. The hypersensitive C-reactive protein level was significantly higher in the LI group than in the nonstroke group and in the unstable plaque group than in the nonplaque group. Conclusions: Hyperhomocysteinemia may aggravate the development of IMT, carotid atherosclerotic plaque instability, and carotid/intracranial artery stenosis by increasing inflammation, ultimately leading to the occurrence of LI. Hyperhomocysteinemia-induced inflammation mechanism warrants further study.

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Section: Effect Of Hyperhomocysteinemia On Carotid Atherosclerosis (Imentioning

confidence: 70%

Study of the Inflammatory Mechanisms in Hyperhomocysteinemia on Large-Artery Atherosclerosis Based on Hypersensitive C-Reactive Protein—A Study from Southern China

Guo

Zhu

2019

Journal of Stroke and Cerebrovascular Diseases

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“…Carotid atherosclerosis plaque is significant in the formation of cerebral infarction. 49 , 50 Research has proven that a slight progression of carotid atherosclerosis significantly and positively increases the prevalence of cardiovascular disease and the risk of future cardiovascular disease events. 51 , 52 Moreover, intima-media thickness of the carotid arteries is a marker of atherosclerosis, as has been assessed pathologically.…”

Section: Discussionmentioning

confidence: 99%

Association of carotid atherosclerosis and recurrent cerebral infarction in the Chinese population: a meta-analysis

Liu¹,

Zhu²,

Wu³

et al. 2017

NDT

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Stroke, when poor blood flow to the brain results in cell death, is the third leading cause of disability and mortality worldwide, and appears as an unequal distribution in the global population. The cumulative risk of recurrence varies greatly up to 10 years after the first stroke. Carotid atherosclerosis is a major risk factor for stroke. The aim of this study was to investigate and estimate the relationship between carotid atherosclerosis and risk of stroke recurrence in the Chinese population. We performed a systematic review and meta-analysis of randomized controlled trials published from 2000 to 2013, using the following databases: PubMed, Embase, Medline, Wanfang, and the China National Knowledge Infrastructure. The odds ratios with 95% confidence intervals were calculated to examine this strength. A total of 22 studies, including 3,912 patients, 2,506 first-ever cases, and 1,406 recurrent cases, were pooled in this meta-analysis. Our results showed that the frequency of carotid atherosclerosis is higher in recurrent cases than that in the first-ever controls (78.88% vs 59.38%), and the statistical analysis demonstrated significant positive association between carotid atherosclerosis and recurrent cerebral infarction (odds ratio: 2.87; 95% confidence interval: 2.42–3.37; P<0.00001) in a fixed-effect model. No significant heterogeneity was observed across all studies. In conclusion, our results showed that carotid atherosclerosis was associated with increased risk of recurrent stroke. However, further well-designed research with large sample sizes is still needed to identify the clear mechanism.

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“…The incidence of embolic cerebral infarction in patients with unstable CAP was higher than in those with stable CAP. Unstable CAP is significant in the formation of cerebral infarction (13–15). Patients with severe carotid stenosis or intracranial vascular stenosis were excluded from the current study.…”

Section: Discussionmentioning

confidence: 99%

Correlation between aortic/carotid atherosclerotic plaques and cerebral infarction

Wang

Sun

Liu

et al. 2013

Experimental and Therapeutic Medicine

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The aim of this study was to investigate the correlation between aortic/carotid atherosclerotic plaques and cerebral infarction. We examined 116 cases of cerebral infarction using transcranial Doppler ultrasound in order to exclude cerebrovascular stenosis. Transesophageal echocardiography and color Doppler ultrasound were used to detect aortic atherosclerotic plaques (AAPs) and carotid atherosclerotic plaques (CAPs). AAPs were detected in a total of 70 of the 116 cases (60.3%), including 56 with moderate/severe atherosclerotic changes (48.3%). The difference in the incidence of various types of infarction between APP severity levels was significant (P<0.01). Of the 116 cases, 64 had CAPs (55.2%), including 46 with unstable plaque (39.7%). The difference in the incidence of various types of infarction between CAP stability levels was significant (P<0.01). The results indicate that moderate/severe AAP and unstable CAP are significant causes of embolic infarction without stenosis in the internal carotid arteries.

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Carotid Atherosclerosis in Ischemic Cerebrovascular Patients

Cited by 3 publications

References 11 publications

Study of the Inflammatory Mechanisms in Hyperhomocysteinemia on Large-Artery Atherosclerosis Based on Hypersensitive C-Reactive Protein—A Study from Southern China

Study of the Inflammatory Mechanisms in Hyperhomocysteinemia on Large-Artery Atherosclerosis Based on Hypersensitive C-Reactive Protein—A Study from Southern China

Association of carotid atherosclerosis and recurrent cerebral infarction in the Chinese population: a meta-analysis

Correlation between aortic/carotid atherosclerotic plaques and cerebral infarction

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