Carotid atherosclerosis is associated with inflammation and endothelial cell adhesion molecules in chronic haemodialysis patients

Papagianni, Αikaterini; Kalovoulos, Michalis; Kirmizis, Dimitrios; Vainas, Andreas; Belechri, Anna-Maria; Alexopoulos, Efstathios; Memmos, Dimitrios

doi:10.1093/ndt/18.1.113

Cited by 113 publications

(101 citation statements)

References 18 publications

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“…There is increasing evidence that uremia per se as well as hemodialysis contributes to the state of chronic inflammation. We and others have shown that soluble adhesion molecules and C-reacting protein are potent early indicators of atherosclerosis in patients on chronic hemodialysis, and are independent predictors of mortality 1) . HMCoA-reductase inhibitors, or statins, are potent lipid lowering drugs.…”

Section: Introductionmentioning

confidence: 84%

“…We consider the CRP and sICAM-1 changes most significant, as they are known to be independent surrogate markers of cardiovascular morbidity and mortality in HD patients 1) . Whether the chronological sequence of the effects of simvastatin re-flect a possible aetiologic connection between the lipid-lowering and pleiotropic effects cannot be answered by the results of the present study and needs further investigation.…”

Section: Discussionmentioning

confidence: 99%

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Effects of simvastatin on markers of inflammation, oxidative stress and endothelial cell apoptosis in patients on chronic hemodialysis

Kirmizis

Papagianni

Dogrammatzi

et al. 2010

JAT

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Efstathios Alexopoulos has passed awayAim: We investigated the effects of simvastatin on markers of inflammation, oxidative stress and endothelial cell apoptosis in hyperlipidemic end-stage renal disease patients on chronic hemodialysis (HD). Methods: In 25 hyperlipidemic HD patients who received 10 mg of simvastatin for 6 months and another 25 controls, the extended lipid profile and serum hsIL-6, MCP-1, sICAM-1, sVCAM-1, and sE-selectin, plasma oxLDL, and serum sFas and sFasL levels were determined at baseline, 3 months and 6 months. In 18 patients of the simvastatin group, the expression of CD14, CD16, CD62L and CD64 on monocyfes was determined with flow cytometry. Result: Simvastatin treatment resulted in significant reductions in serum lipid levels at 3 months and beyond, compared to at baseline. Moreover, at 6 months, simvastatin caused a significant reduction in CRP ( p 0.001), which correlated to the decrease in total and LDL cholesterol levels, as well as a significant reduction in IL-6 ( p 0.001), sICAM-1 ( p 0.001), sVCAM-1 ( p 0.001), oxLDL ( p 0.001), sFas ( p 0.02) and CD14 expression ( p 0.001), compared to baseline values. No significant changes in the controls were noticed during the study. Conclusion: In conclusion, in hyperlipidemic HD patients, simvastatin treatment resulted in a significant reduction in markers of endothelial dysfunction, inflammation, oxidative stress, endothelial cell apoptosis and peripheral blood monocyte stimulation. The reduction in CRP appears to be related to the lipid-lowering effects of simvastatin.

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Section: Introductionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Effects of simvastatin on markers of inflammation, oxidative stress and endothelial cell apoptosis in patients on chronic hemodialysis

Kirmizis

Papagianni

Dogrammatzi

et al. 2010

JAT

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show abstract

“…Although some studies showed that high sVCAM is associated with CV events (6), others (including the present study) showed no association. Conversely, prior data in pre-dialysis and HD populations indicated that elevated sICAM, but not sVCAM, predicts increased mortality (29)(30)(31) with flow-mediated dilation, malnutrition, and inflammation in PD patients. Our data again support the prognostic value of sICAM, but not sVCAM, in PD patients.…”

Section: Discussionmentioning

confidence: 85%

Prognostic Value of Serum Von Willebrand Factor, but Not Soluble Icam and Vcam, for Mortality and Cardiovascular Events is Independent of Residual Renal Function in Peritoneal Dialysis Patients

Dong

Yang

et al. 2014

Perit Dial Int

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♦ Objective: We explored associations between markers of endothelial dysfunction and outcome events, and whether those associations were independent of residual renal function (RRF) in patients on peritoneal dialysis. ♦ Methods: The study enrolled 261 incident patients and 68 healthy control subjects who were followed till death, censoring, or study end. Demographics, biochemistry, markers of inflammation (C-reactive protein) and endothelial dysfunction [soluble intercellular adhesion molecule 1 (sICAM), soluble vascular adhesion molecule 1 (sVCAM), and von Willebrand factor (vWf)] were examined at baseline. Outcome events included all-cause death and fatal and nonfatal cardiovascular (CV) events. ♦ Results: Mean levels of vWf, sICAM, and sVCAM were significantly higher in patients than in healthy control subjects. Levels of sICAM and sVCAM, but not vWf, were significantly correlated with RRF. Levels of sICAM and vWf both predicted all-cause mortality and fatal and nonfatal CV events after adjustment for recognizable CV risk factors. The association between sICAM and outcome events disappeared after further adjustment for RRF. However, RRF did not change the predictive role of vWf for outcome events. Compared with the lowest vWf quartile (6.6% -73.9%), the highest vWf quartile (240.9% -1161%) predicted the highest risk for fatal and nonfatal CV events (adjusted hazard ratio: 2.05; 95% confidence interval: 1.15 to 3.64; p = 0.014). We observed no associations between sVCAM and RRF, or sVCAM and any outcome event. ♦ Conclusions: The prognostic value of vWf, but not sICAM, is independent of RRF in predicting mortality and CV events.Perit Dial Int 2014; 34(7):706-713 www.PDIConnect.com epub ahead of print:

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“…Pada pasien penyakit ginjal kronis yang menjalani dialisis, terjadi peningkatan stres oksidatif dan inflamasi yang persisten dimana terdapat beberapa produk metabolisme oksidatif yang dihasilkan yaitu Advanced Glycation End Product (AGE), Advanced Oxidation Protein Products (AOPP) dan Homocystein yang semuanya mengakibatkan terjadinya stress oksidatif. [1][2][3] Banyak data yang mendukung konsep bahwa peningkatan stres oksidatif berperan dalam komplikasi kardiovaskuler pada penyakit ginjal kronis, maka dapat dihipotesiskan bahwa terapi antioksidan dapat bermanfaat dalam menurunkan insiden kardiovaskuler. Pada penelitian yang dilakukan oleh Tepel dkk tahun 2003, pemberian N-Acetylcysteine jangka panjang pada pasien penyakit ginjal kronis yang menjalani hemodialisis dapat menurunkan cardiac event, stroke iskemik, peripheral vascular disease.…”

Section: Pendahuluanunclassified

Pengaruh Pemberian N-Acetylcysteine Oral terhadap High Sensitivity C Reactive Protein (Hs-CRP) pada Pasien Hemodialisis Kronis

Dewi¹,

Siregar²,

Alwi³

et al. 2017

JPDI

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ABSTRAKPendahuluan. Inflamasi dan stres oksidatif merupakan faktor risiko penyakit kardiovaskuler pada pasien penyakit ginjal kronis yang menjalani hemodialisis. Pasien hemodialisis kronis akan mengalami peningkatan kadar Hs-CRP. Hs-CRP merupakan marker inflamasi yang telah terbukti pada beberapa penelitian bermanfaat dalam memprediksi cardiovascular event.Pemberian N-Acetylcysteine (NAC) oral dapat digunakan sebagai strategi untuk menurunkan proses inflamasi yaitu disfungsi endotel dan stress oksidatif yang berperan pada atherosclerosis pada pasien hemodialsis. Pemberian NAC ini diharapkan dapat menurunkan angka morbiditas dan mortalitas karena penyakit kardiovaskuler. Metode. Penelitian eksperimen dengan Randomized Double Blind ControlledTrial pada 65 pasien hemodialisis kronis yang memenuhi kriteria inklusi di unit hemodialisis RS.Cipto Mangunkusumo Jakarta. Penelitian dilakukan pada Agustus sampai Oktober 2013Hasil. Perlakuan dengan NAC oral selama 60 hari tidak memberikan perbedaan dibandingkan dengan plasebo. Analisis statistik dengan Mann Whitney menunjukkan bahwa tidak ada penurunan kadar Hs-CRP yang signifikan diantara kedua kelompok dengan p value ∆ post1-baseline, ∆ post2-baseline, and ∆ post2-post1 kelompok NAC dibanding kelompok plasebo secara berurutan yaitu 0.796, 0.379 dan 0.712. Sementara itu, hasil uji Wilcoxon Signed Ranks untuk membandingkan penurunan kadar Hs-CRP pada tiap kelompok dalam tiga interval pengukuran Hs-CRP menunjukkan p value dari perbandingan kadar Hs-CRP untuk masing-masing kelompok baseline:Post1, baseline:Post2 dan Post1:Post2 (kelompok NAC Vs kelompok plasebo) secara berurutan 0.821vs0.651; 0.845vs0.358 dan 0.905vs0.789.Simpulan. Pemberian N-Acetylcysteine oral belum terbukti dapat menurunkan kadar Hs-CRP pada pasien hemodialisis kronis.

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Carotid atherosclerosis is associated with inflammation and endothelial cell adhesion molecules in chronic haemodialysis patients

Cited by 113 publications

References 18 publications

Effects of simvastatin on markers of inflammation, oxidative stress and endothelial cell apoptosis in patients on chronic hemodialysis

Effects of simvastatin on markers of inflammation, oxidative stress and endothelial cell apoptosis in patients on chronic hemodialysis

Prognostic Value of Serum Von Willebrand Factor, but Not Soluble Icam and Vcam, for Mortality and Cardiovascular Events is Independent of Residual Renal Function in Peritoneal Dialysis Patients

Pengaruh Pemberian N-Acetylcysteine Oral terhadap High Sensitivity C Reactive Protein (Hs-CRP) pada Pasien Hemodialisis Kronis

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