Carotid endarterectomy with saphenous vein patch angioplasty: a single-center experience

Esposito, Andrea; Menna, Danilo; Baiano, A.; Benedetto, Pietro; Leo, Ferdinando Di; Trani, Antonio; Cappiello, Antonino Pierluigi

doi:10.23736/s2724-5683.21.05685-4

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…Patch angioplasty is a commonly used technique to prohibit potential stenosis after vascular surgery, traditional patch materials like prosthetic Dacron and expanded polytetrafluoroethylene patches have contributed to the advancement of vascular surgery, but as foreign materials, they have the potential risk of infection and pseudoaneurysm formation (den Hoed and Veen, 1992;Eads and Ikonomidis, 2014). Autologous vein patch is also commonly used, but it is inclined to bulge after implantation because of high compliance (Esposito et al, 2021). So better or novel materials are needed in both the clinic and basic research, and with the rapid development of science and techniques in biomaterials science, natural materials have attracted more and more attention.…”

Section: Introductionmentioning

confidence: 99%

Egg Shell Membrane as an Alternative Vascular Patch for Arterial Angioplasty

Sun

Yan

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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Introduction: The egg shell membrane (ESM) is always considered as waste, but recent studies have shown that it has the potential to yield rapid re-endothelialization in vitro. We hypothesized that ESM and heparin-conjugated ESM (HESM) can be used as arterial patch in a rat aortic angioplasty model.Method: Sprague-Dawley rat (200 g) abdominal aortic patch angioplasty model was used. Decellularized rat thoracic aorta (TA) patch was used as the control; ESM patch was made of raw chicken egg; heparin-coated ESM (HESM) patch was made by using dopamine; anticoagulation properties were verified using platelet adhesion tests; the TA, ESM, and HESM patches were implanted to the rat aorta and harvested at day 14; and the samples were examined by immunohistochemistry and immunofluorescence.Result: The ESM patch showed a similar healing process to the TA patch; the cells could migrate and infiltrate into both patches; there was a neointima with von Willebrand factor-positive endothelial cells; the endothelial cells acquired arterial identity with Ephrin-B2- and dll-4-positive cells; there were proliferating cell nuclear antigen (PCNA)-positive cells, and PCNA and alpha smooth muscle actin dual-positive cells in the neointima in both groups. Heparin was conjugated to the patch successfully and showed a strong anticoagulation property in vitro. HESM could decrease mural thrombus formation after rat aortic patch angioplasty.Conclusion: The ESM is a natural scaffold that can be used as a vascular patch; it showed a similar healing process to decellularized TA patch; HESM showed anticoagulation property both in vitro and in vivo; and the ESM may be a promising vascular graft in the clinic.

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Section: Introductionmentioning

confidence: 99%