Carotid Intima-Media Thickness and Coronary Artery Disease: An Indian Perspective

Gupta, Hansa; Bhargava, Kartikeya; Bansal, Manish; Tandon, Sharad; Kasliwal, Ravi R

doi:10.1177/021849230301100308

Cited by 46 publications

(30 citation statements)

References 21 publications

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“…Visona and colleagues [25] showed that CIMT in CAD patients (1.45 ± 0.95) was significantly higher than in controls (0.87 ± 0.1; p < 0.005). Hansa et al [26] reported association of CIMT with CAD and CV risk factors in the Indian population, CIMT measured on each side, was significantly higher in the coronary disease group compared to the controls. In this respect, the results of present study (0.80 ± 0.22, 0.69 ± 0.13, p < 0.005) ( Table 2) are in agreement with previous studies showing a significant association between raised CIMT and the presence of CAD.…”

Section: Discussionmentioning

confidence: 97%

Role of CIMT, eGFR, and Serum HbA1c in Predicting CAD in Non-Diabetic Patients Undergoing Elective Coronary Angiography

Kapil¹,

Rajasekhar²,

Vanjakshamma³

et al. 2018

WJCD

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Background: Pre-diabetic state, renal function, atherosclerosis burden are the major predictors for development of coronary artery disease (CAD). Present study aims to analyze the role of carotid intima-media thickness (CIMT), glomerular filtration rate (eGFR) and serum glycosylated hemoglobin (HbA1c) levels in predicting CAD on coronary angiography in non-diabetic patients. Methods: CAD and its severity according to SYNTAX score (SX score) was evaluated in 450 non-diabetic patients hospitalized with acute coronary syndrome or stable angina and underwent coronary angiography. CIMT, eGFR, and serum HbA1c values were obtained during admission. Spearman correlation and linear regression were used in the analysis of the data. Receiver operating characteristic (ROC) curve was constructed to calculate cutoff values, area under curve (AUC), sensitivity and specificity. Results: Statistically significant positive correlation was observed between HbA1c (r: 0.242, p = 0.001); CIMT (r: 0.231, p = 0.001), patient's age (r: 0.148, p = 0.002) and SX score, whereas eGFR was negatively correlated (r: −0.148, p = 0.002). On regression analysis, CIMT, eGFR, HbA1c and patient's age collectively predicted 36% of change in the SYNTAX score. Patient's age > 56 years (AUC = 0.622), CIMT > 0.86 mm (AUC = 0.642), HbA1c > 6 (AUC = 0.620), eGFR < 92 ml/min/1.73 m 2 (AUC = 0.601) were the cutoff values on ROC curve analysis.CIMT, HbA1c had relatively high specificity (88.5%, 90.2% respectively) and eGFR had relatively high sensitivity (71.3%) among the studied variables in predicting CAD in present study. Conclusions: CIMT, HbA1c, eGFR and patient's age at the time of admission predict CAD in non-diabetic patients undergoing coronary angiography.

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Section: Discussionmentioning

confidence: 97%

Role of CIMT, eGFR, and Serum HbA1c in Predicting CAD in Non-Diabetic Patients Undergoing Elective Coronary Angiography

Kapil¹,

Rajasekhar²,

Vanjakshamma³

et al. 2018

WJCD

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“…Asian Indians are reported to have three times higher rates of incidence and prevalence of CAD when compared with western populations, [1,2] leading to a greater social and economic impact. [3,4] Various factors, such as metabolic syndrome, diabetes, dyslipidemia and possible genetic predisposition are believed to contribute to this rising epidemic in India.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of IFN- γ, Inflammatory Marker And Infectious Etiology As Risk Factors For Coronary Artery Disease

Rizvi

Haider

Gupta

et al. 2018

APALM

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Background:We evaluated the role of Chlamydia pneumoniae (C. pneumoniae) and Cytomegalovirus (CMV) infection in coronary artery disease(CAD) patients. Interferon-γ (IFN-γ) levels in serum were assessed for ongoing inflammatory activity by these microorganisms. Materials and Methods:Persistent and chronic infection of C. pneumoniae was assessed by the level of IgA and IgG antibodies as well as 16S rRNA gene of C.pneumoniae. Chronic CMV presence was detected by IgG antibodies. IFN-γ levels in serum were analysed by ELISA.Results: Among the 63 CAD cases, C. pneumoniae IgG antibodies were present in 34(53.97%;95% CI: 41.66% to 66.28%) cases, C. pneumoniae IgA antibodies were detected in 42(66.67%; 95% CI :55.03% to78.31%) cases (p<0.05). PCR for detection of C. pneumoniae was done on 40 cases, among which 13 (32.5%; 95% CI: 17.99% to 47.01%) of cases were positive for 16SrRNA gene of C. pneumoniae. CMV IgG was positive in 41 (65.08%; 95% CI: 53.31% to 76.85%) cases. On assessing the patients of CAD for major traditional risk factors,35(55.55%) had past history of CAD, 20(31.75%) of dyslipidemia, 19 (30.16%) gave history of smoking and 18 (28.75%) were obese. On comparison of infectious etiology and traditional risk factors, it was clear that C. pneumoniae and CMV both were more (p<0.001) strongly associated with CAD than the traditional risk factors. Mean level of IFN-γ in these patients was 32.13pg/ml and that of controls was 11.32pg/ml. Raised IFN-γ was observed in 39 (61.9%) patients of which 14 (35.9%) were patients of primary hypertension, 7 (17.9%) were patients of angina and 18 (46.15%) were patients of MI. Conclusions:C. pneumoniae and chronic CMV infection appear to have a role in the pathogenesis of CAD. Elevated IFN-γ levels suggests that these pathogens aggravate the inflammatory process of atherogenesis and hasten the disease process.

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“…In India, Hansa G et al, 14 study was done in 2003 to determine whether CIMT is associated with CAD and cardiovascular risk factors in the Indian population. A total of 101 patients with CAD and 140 control subjects were assessed for CIMT and other conventional CVD risk factors.…”

Section: Resultsmentioning

confidence: 99%

A Comparative Study of Carotid Intima Media Thickness as a Surrogate Marker for Cardiovascular Events in Rural Dakshina Kannada Population

C¹,

Tejasvi²,

Hiremath³

et al. 2015

jemds

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BACKGROUND & PURPOSE:Carotid artery intima media thickness (CIMT) is used as a noninvasive surrogate marker to measure progression of atherosclerosis, but its relation to coronary events has not been fully explored. CIMT determined by B-mode ultrasonography (USG) is a valid and measurable index of atherosclerosis. Atherosclerosis is strongly associated with cardiovascular risk factors and thus CIMT has the ability to predict cardiovascular diseases.

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Carotid Intima-Media Thickness and Coronary Artery Disease: An Indian Perspective

Cited by 46 publications

References 21 publications

Role of CIMT, eGFR, and Serum HbA1c in Predicting CAD in Non-Diabetic Patients Undergoing Elective Coronary Angiography

Role of CIMT, eGFR, and Serum HbA1c in Predicting CAD in Non-Diabetic Patients Undergoing Elective Coronary Angiography

Evaluation of IFN- γ, Inflammatory Marker And Infectious Etiology As Risk Factors For Coronary Artery Disease

A Comparative Study of Carotid Intima Media Thickness as a Surrogate Marker for Cardiovascular Events in Rural Dakshina Kannada Population

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