Carotid Intima-media thickness in childhood and adolescent obesity relations to abdominal obesity, high triglyceride level and insulin resistance

Fang, Jie; Zhang, Jian Ping; Luo, Cai Xia; Yu, Xiaonan; Lv, Lei

doi:10.7150/ijms.7.278

Cited by 51 publications

(50 citation statements)

References 24 publications

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“…Age, BMI, triglycerides and CRP are the main determinants of carotid IMT increase, as demonstrated by multiple regression analysis. These results were not in agreement with literature [25][26][27][28]. Kelishadi et al [25] found a direct, positive correlation (r = 0.27, p b 0.05) between cIMT and HOMA index among their 35 obese children and adolescent.…”

Section: Discussioncontrasting

confidence: 60%

Insulin resistance and endothelial function in children and adolescents

Miniello

Faienza

Scicchitano

et al. 2014

International Journal of Cardiology

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Section: Discussioncontrasting

confidence: 60%

Insulin resistance and endothelial function in children and adolescents

Miniello

Faienza

Scicchitano

et al. 2014

International Journal of Cardiology

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“…31 High triglyceride levels and the IR index (HOMA-IR) were strong, independent predictors of increased carotid intima-media thickness, which was a non-invasive measure of subclinical atherosclerosis in paediatric research. 32 Nevertheless, low HDL cholesterol level carried an even greater relative risk than high triglyceride levels. 33 Compared with those without AN, subjects with the condition had a higher mean triglyceride level (P<0.001) but lower HDL level (P<0.001), and hence their future cardiovascular health seems to be of great concern.…”

Section: Discussionmentioning

confidence: 99%

Acanthosis nigricans in obese Chinese children

Young

Huen

et al. 2014

Hong Kong Med J

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Objectives: To investigate the demographic characteristics and insulin resistance in local overweight/obese Chinese children with and without acanthosis nigricans, and the associations of acanthosis nigricans with insulin resistance and other cardiometabolic co-morbidities.Design: Case series with cross-sectional analyses.Setting: A regional hospital in Hong Kong.Patients: Chinese children assessed between January 2006 and December 2010 at Tseung Kwan O Hospital for being overweight or obese. Main outcome measures:The demographics, anthropometric data, acanthosis nigricans status, and biochemical results were analysed.Results: A total of 543 overweight/obese children were studied with 64% being boys and 29% had insulin resistance. Adolescents aged 12 to 18 years, compared with children aged 5 to 11 years, were more likely to have acanthosis nigricans (63% vs 47%; P<0.001) and insulin resistance (37% vs 25%; P=0.005). Compared with overweight children, those who were obese were more likely to have the two conditions: acanthosis nigricans (59% vs 44%; P=0.005) and insulin resistance (35% vs 19%; P=0.001). Compared with those without acanthosis nigricans, those with the condition had significantly higher mean values for systolic blood pressures Acanthosis nigricans in obese Chinese children IntroductionObesity was formally recognised as a global epidemic by the World Health Organization (WHO) in 1997. 1During the past decades, the prevalence of being overweight and obese has increased substantially. In Hong Kong, 17% of children were overweight/obese in 2005/6, which was a 5% increase since 1993, based on International Obesity Task Force cut-offs. 2Overweight/obese children and adolescents are more likely to have hyperinsulinaemia, hypertension, and dyslipidaemia. 3 The clustering of cardiometabolic risk factors in these patients tends to track into adult life.3 However, the Diabetes New knowledge added by this study • Hong Kong Chinese children with acanthosis nigricans were more likely to have insulin resistance, hypertension, fatty livers, and abnormal glucose homeostasis. Implications for clinical practice or policy • In children, acanthosis nigricans is an important clinical sign warranting early attention and evaluation.

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“…La obesidad, según IMC, en nuestro estudio no se asoció con incremento de CIMT, a diferencia de otros estudios mencionados en el párrafo anterior. El PC tampoco se asoció aunque se ha demostrado su habilidad diagnóstica para el riesgo cardiovascular en niños y adultos [30][31][32] . Para ambos casos es posible que con un tamaño muestral mayor se relacionen con CIMT.…”

Section: Discussionunclassified