Carotid Intima-Media Thickness in Patients with Diabetes Mellitus Attending Tertiary Care Hospital in Nigeria

Baba, M M; Talle, Mohammed Abdullahi; Ibinaiye, Philip Oluleke; Abdul, Habu; Buba, Faruk

doi:10.4172/2329-9495.1000210

Cited by 7 publications

(4 citation statements)

References 28 publications

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“…These findings are statistically significant in both groups (p=0.000 and p=0.019). This finding is in agreement with the previous studies (Hassan et al, 2016;Baba et al, 2018). The possible reason for such variations between right and left CCIMT is not yet clear.…”

Section: Discussionsupporting

confidence: 92%

Sonographic evaluation of common carotid artery intima-media thickness in adults with coexisting type two (2) diabetes and hypertension: A case-controlled study

Ali,

Ugwu,

Mohammed

et al. 2023

dujopas

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Diabetes mellitus (DM) and hypertension (HTN) are the two leading risk factors for atherosclerosis. Carotid intima-media thickness (CIMT) is considered a reliable surrogate measure for detecting subclinical atherosclerosis including its progression and regression. The study aim at evaluating the intima-media thickness of the common carotid artery in adults with coexisting diabetes mellitus and hypertension (DM+HTN) and compare with healthy controls.. A prospective case control study involving 115 adult subjects with coexisting DM+HTN and 144 healthy adult controls was carried out. Common carotid intima-media thickness (CCIMT) was measured at point approximately 1 cm distal to the right and left carotid bulb using the 7-12 MHz, multi-frequency linear array transducer of high resolution, touch Venue 50 ultrasound machine equipped with electronic callipers. The overall mean CCIMT was 1.13±0.40 mm and 0.82±0.23 mm for subjects with coexisting DM and HTN; and healthy controls, respectively. There was a statistically significant difference in CIMT of subjects with DM+HTN compared to healthy controls (p=0.000 each for both males and females, respectively). There were positive correlations between CCIMT and age in subjects with DM+HTN (r=0.260 and r=0.424 for males and females respectively); with healthy controls (r=0.619 and 0.626 for males and females, respectively). There was a statistically significant difference in CCIMT between subjects with DM+HTN and healthy controls. This implies that the increase in CCIMT is associated with both DM and HTN. In addition, age has a significant positive relationship with CCIMT in both subjects with DM+HTN and healthy controls.

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Section: Discussionsupporting

confidence: 92%

Sonographic evaluation of common carotid artery intima-media thickness in adults with coexisting type two (2) diabetes and hypertension: A case-controlled study

Ali,

Ugwu,

Mohammed

et al. 2023

dujopas

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“…This prevalence is significantly lower when compared to similar studies such as Baba et al in which the diabetic group had a significantly higher mean CIMT compared to control at all levels. Seventy-nine (90.8%) of the patients with diabetes in this particular study had CIMT greater than 0.9 mm, while sixty-nine (79.3%) had CIMT greater than 1.0 mm [30] . This discrepancy in prevalence size may be due to inclusion of hypertensive patients, patients with elevated cholesterol which resulted in a broader sample size as opposed to this study which excluded patients with elevated blood pressure, stroke, elevated cholesterol levels resulting in a much smaller sample size which in turn resulted in a smaller prevalence.…”

Section: Discussionmentioning

confidence: 60%

The Carotid Intima Medial Thickness Among Type 2 Diabetes Mellitus and Controls: A Cross Sectional Study

EDAFE,

Akpa

2024

ijirms

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Introduction: In Nigeria, the prevalence of diabetes mellitus has been on increasing steadily. With the increasing prevalence of diabetes mellitus, one expects higher rate of its complications including carotid atherosclerosis (which may present with silent infarct, transient ischemic attack, or ischemic stroke) and coronary artery disease. The common link between carotid atherosclerosis and coronary artery disease is atherosclerotic cardiovascular disease with increase intimal medial thickness. This study evaluated medial intima thickness of among Diabetes at the University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria. Methods and Materials: The study was a descriptive cross-sectional, to assess relationship between peripheral artery disease and carotid atherosclerosis among type 2 diabetic subjects in UPTH using the ankle brachial pressure index and carotid intima-medial thickness. 110 diabetic subjects, and 110 age and gender matched non-diabetic, controls were recruited for the study. Type 2 diabetic subjects and controls that met the inclusion criteria and consented were recruited consecutively as they met the inclusion criteria. Demographic data, anthropometric measures were taken and recorded. Using a structured questionnaire, information on medical history, physical examination and examination of carotid intima-medial thickness were measured and documented. Confidentiality was maintained throughout the 13 months period of the study. Data obtained were checked for errors and corrected before being analyzed using the statistical package for social sciences software 20.0 (SPSS 20.0). Results: There were 67 females and 43 males with type 2 diabetes, while 61 Females and 49 males served as controls. The mean age for the diabetic subjects was 54.85 ± 10.09, while that for the controls was 52.86 ± 10.31. The mean duration of diabetes mellitus was 6.24 ± 4.53. The patient with CIMT more than 1mm account for 19.1% of the subjects, while the controls had 7.3% Th is statistically significant with a p-vale of <0.001. Increased thickness of the carotid intima-medial was found to be significantly associated, increasing duration of diabetes. Conclusion: CIMT is more common in diabetic patients compared to age and gender-match controls. Most subjects with increased CIMT are asymptomatic.

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“…Carotid intima-media thickness and plaque: the mean CIMT in this study was similarly reported by Baba et al . [ 31 ]. However, its value is higher than that reported in Turkey [ 32 ] and lower than the controls of Koc et al .…”

Section: Discussionmentioning

confidence: 99%

“…The CIMT at the CB being significantly higher than the CCA and ICA as similarly reported by Baba et al . [ 31 ] may be due to anatomy at carotid artery bifurcation and resultant hemodynamic changes [ 34 ]. The increased CIMT observed in our study participants was lower than 53.7% and 36.5% reported by Omisore et al .…”

Section: Discussionmentioning

confidence: 99%

Ultra sonographic indices of the carotid artery in healthy adult population of southwest, Nigeria: a cross-sectional study

Adekoya¹,

Olatunji²,

Akinola³

et al. 2023

Pan Afr Med J

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Introduction atherosclerosis develops insidiously, offering time and opportunities for early detection. Screening for subclinical atherosclerosis via structural wall changes and flow velocities among apparently healthy adults using carotid ultrasonography may help its early detection, offer timely intervention and reduce morbidity and mortality. Methods a cross-sectional study of 100 participants with a mean age of 56.1 ± 6.9 years, were enrolled from a community population. Both carotid arteries were examined for plaques, carotid intima-media thickness (CIMT), and flow velocities - peak systolic velocity (PSV), end-diastolic velocity (EDV), pulsatility index (PI), and resistive index (RI) using 4-12MHz linear array transducer. Visceral obesity, serum lipids, and blood glucose were also evaluated and correlated with ultrasound findings. Results the mean CIMT was 0.07 ± 0.02cm and 15% of the participants had increased CIMT. Statistically significance but weak correlations were observed between CIMT and FBG (r = 0.199, p = 0.047), EDV (r =0.204, p= 0.041), PI (r = -0.287, p = 0.004) and RI (r = -0.268, p =0.007). Statistically significance with modest correlations were observed between EDV and PSV (r = 0.48, p = 0.000), PI (r = -0.635, p = 0.000) and RI (r = -0.637, p = 0.000). The PI and RI showed strong correlation with statistical significance (r= 0.972, p = 0.000). Conclusion statistical significance in the flow velocities, derived flow indices and increased CIMT may be an early indication of subclinical atherosclerosis. Therefore, ultrasonography may facilitate its early detection and possible prevention of complications.

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Carotid Intima-Media Thickness in Patients with Diabetes Mellitus Attending Tertiary Care Hospital in Nigeria

Cited by 7 publications

References 28 publications

Sonographic evaluation of common carotid artery intima-media thickness in adults with coexisting type two (2) diabetes and hypertension: A case-controlled study

Sonographic evaluation of common carotid artery intima-media thickness in adults with coexisting type two (2) diabetes and hypertension: A case-controlled study

The Carotid Intima Medial Thickness Among Type 2 Diabetes Mellitus and Controls: A Cross Sectional Study

Ultra sonographic indices of the carotid artery in healthy adult population of southwest, Nigeria: a cross-sectional study

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