Carotid intima‐media thickness in young survivors of childhood cancer

Krawczuk‐Rybak, Maryna; Tomczuk-Ostapczuk, Monika; Panasiuk, Anna; Gościk, Elżbieta

doi:10.1111/1754-9485.12510

Cited by 11 publications

(13 citation statements)

References 37 publications

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“…failed to find any differences in IMT between irradiated and nonirradiated females. 23 In another article authors did not observe significant differences in IMT between cancer survivors treated with chemotherapy only versus those treated with chemotherapy and radiotherapy. 24 Beside that in articles with significant differences in IMT between irradiated and nonirradiated patients those differences were very small and still in a normal range.…”

Section: Discussionmentioning

confidence: 94%

Is carotid stiffness a possible surrogate for stroke in long-term survivors of childhood cancer after neck radiotherapy?

Zadravec-Zaletel

Popit

Zaletel

2018

Radiology and Oncology

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BackgroundThe risk for cerebrovascular late effects among childhood cancer survivors is considerable. According to recent studies it is not clear which marker could be reliable for the screening of cerebrovascular diseases among the long-term survivors of childhood cancer. The purpose of this study is to analyse arterial stiffness and intima-media thickness as possible early markers of later occurring stroke in long-term survivors of childhood cancer after neck radiotherapy.Patients and methodsTwenty-three patients, treated for Hodgkin disease (HD) in childhood, were included. They had received radiation therapy to the neck with 20–65 (median 30) Gy. Twenty-six healthy controls, matched in age, sex, body mass index, arterial hypertension, smoking history and total cholesterol levels were compared. Highresolution colour-coded duplex sonography and power Doppler sonography of the carotid arteries were performed and intima-media thickness, number and quality of plaques were measured. Arterial stiffness indices were calculated.ResultsPlaque deposits and/or arterial wall calcinations were found in 24 out of 43 (55.8%) irradiated vessels in cancer survivors group and 0 out of 52 vessels in the group of healthy controls (p < 0.01). We found significant group differences for all the stiffness parameters we used (P < 0.05), but there was no difference in intima-media thickness between cases and controls (p = 0.92). In a multivariate model, carotid pulse wave velocity was positively associated with smoking.ConclusionsThe arterial stiffness has appeared as a possible surrogate marker for stroke in long-term survivors of childhood cancer. Smoking habit might have an additional negative influence on vascular aging in the group of patients after neck radiotherapy.

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Section: Discussionmentioning

confidence: 94%

Is carotid stiffness a possible surrogate for stroke in long-term survivors of childhood cancer after neck radiotherapy?

Zadravec-Zaletel

Popit

Zaletel

2018

Radiology and Oncology

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“…It can be assessed using ultrasound at a young age and long before atherosclerotic symptoms occur. Although the incidence of carotid plaques is low in this age group, cIMT may be elevated in children and adolescents with obesity (4,5), hypertension (6), diabetes (7), cancer (8), or some types of congenital heart disease (9).…”

Section: Introductionmentioning

confidence: 99%

Vascular Structure and Function in Children and Adolescents: What Impact Do Physical Activity, Health-Related Physical Fitness, and Exercise Have?

et al. 2020

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“…1 Increased CIMT was found in children with metabolic syndrome, congenital adrenal hyperplasia, obesity, type 1 diabetes mellitus, and also in childhood cancer survivors. [2][3][4][5][6][7] However, the lack of pediatric, population-based reference values makes CIMT not a widely accepted marker of subclinical atherosclerosis in youth with cardiovascular risk factors. 8 The developing cardiovascular system in children is highly susceptible to the toxic effects of chemotherapeutic agents and their administration may cause endothelial damage leading to endothelial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

CIMT does not identify early vascular changes in childhood acute lymphoblastic leukemia survivors

Ociepa¹,

Posio²,

Sawicki³

et al. 2020

Adv Clin Exp Med

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Background. Childhood acute lymphoblastic leukemia (ALL) survivors are at an increased risk of cardiovascular disease development. It is believed that in the general population, this risk can be predicted with carotid intima-media thickness (CIMT) measurement. Objectives. The objective of this study was to assess CIMT and to investigate the effects of blood pressure (BP) and lipid profile values on CIMT in childhood ALL survivors. Material and methods. The study group comprised 81 childhood ALL survivors aged 5-25 years. The control group consisted of 52 age-and sex-comparable healthy children. Carotid intima-media thickness measurement, 24-hour BP monitoring and lipid profiles were evaluated in patients and controls. Results. Despite significantly higher proportion of subjects with arterial hypertension (AH) (30/81 vs 10/52; p = 0.0315), the mean values of CIMT were not statistically different in childhood ALL survivors as compared to controls (0.4303 ±0.03 vs 0.4291 ±0.03; p = 0.81 and 1.096 ±0.74 vs 1.027 ±0.55; p = 0.56, respectively). Carotid intima-media thickness values were not statistically higher in ALL survivors with AH as compared to ALL survivors with normal BP (0.433 ±0.03 vs 0.428 ±0.03; p = 0.82). A significant positive correlation between 24-hour systolic BP standard deviation score (SDS) and CIMT-SDS in childhood ALL survivors was found (r = 0.29, p = 0.009), whereas such correlation was not observed in healthy controls (r = 0. 12, p = 0.39). A significant correlation between z-score body mass index (BMI) and CIMT was found in controls (r = 0.29, p = 0.031) but not in childhood ALL survivors (r = −0.05, p = 0.64). No significant correlations between CIMT and other measured variables were found. Carotid intima-media thickness did not significantly correlate with time since ALL diagnosis (r = 0.09, p = 0.39). Conclusions. Carotid intima-media thickness measurement shows limited feasibility and diagnostic accuracy for early assessment of vascular alteration in childhood ALL survivors. Other tests are needed to predict cardiovascular risk in childhood ALL survivors at the early stage of the follow-up.

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Carotid intima‐media thickness in young survivors of childhood cancer

Abstract: Anticancer treatment during childhood, especially including irradiation to the mediastinum, head or neck, affects the IMT, particularly in males. This suggests a possible role of irradiation in the premature development of carotid artery disease.

Cited by 11 publications

References 37 publications

Is carotid stiffness a possible surrogate for stroke in long-term survivors of childhood cancer after neck radiotherapy?

Is carotid stiffness a possible surrogate for stroke in long-term survivors of childhood cancer after neck radiotherapy?

Vascular Structure and Function in Children and Adolescents: What Impact Do Physical Activity, Health-Related Physical Fitness, and Exercise Have?

CIMT does not identify early vascular changes in childhood acute lymphoblastic leukemia survivors

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