2011
DOI: 10.1016/j.ymgme.2010.11.150
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Carotid Intima-Media thickness is increased in patients with mucopolysaccharidoses

Abstract: Background-The feasibility of carotid artery intima-media thickness (C-IMT), an established cardiovascular disease marker, as a cardiac risk marker in mucopolysaccharidosis (MPS) patients was explored.

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Cited by 3 publications
(3 citation statements)
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“…In MPS patients, arterial luminal stenosis was observed to be caused by intimal medial proliferation [104]. In addition, there was significantly increased carotid intima-media thickness (CIMT) [105] in patients with MPSs than matched controls [106]. These findings were further validated by another study carried out in a pediatric cohort of MPS patients by a larger, dual-center assessment of 25 MPS Type I and II patients.…”
Section: Arterial Stiffeningmentioning
confidence: 70%
“…In MPS patients, arterial luminal stenosis was observed to be caused by intimal medial proliferation [104]. In addition, there was significantly increased carotid intima-media thickness (CIMT) [105] in patients with MPSs than matched controls [106]. These findings were further validated by another study carried out in a pediatric cohort of MPS patients by a larger, dual-center assessment of 25 MPS Type I and II patients.…”
Section: Arterial Stiffeningmentioning
confidence: 70%
“…This leads to accumulation of glycolipids and mucopolysaccharides within various tissues throughout the body, including the heart valves and smooth muscle cells of the coronary arteries causing diffuse narrowing. 2,7 9 A report by van den Broek et al demonstrated progressive narrowing of the left coronary artery over several months, leading to cardiac failure and death in an infant with mucopolysaccharidosis I (Hurler syndrome). 2 Rentería et al described gross autopsy findings of thickened aortic and mitral valves and diffuse thickening of the carotid arterial walls, causing severe narrowing at multiple levels, in five patients with Hurler syndrome, none of whom had symptoms of heart failure.…”
Section: Discussionmentioning
confidence: 99%
“…The parameters measured by RF data technology have good reproducibility and are more accurate; it has become a commonly used technique in vascular research in recent years. Reports on the relationship between large arterial structures and elastic indexes in CV events indicate the possibility of early detection of CAD noninvasively [5,9,10]. In the present study, we adapted this method for analyzing carotid artery with the aim of assessing arterial wall changes in patients with CAD.…”
Section: Introductionmentioning
confidence: 99%