Carotid plaque, a subclinical precursor of vascular events

Rundek, Tatjana; Arif, Hiba; Boden‐Albala, Bernadette; Elkind, Mitchell S.V.; Paik, Myunghee Cho; Sacco, Ralph L.

doi:10.1212/01.wnl.0000303969.63165.34

Cited by 275 publications

(262 citation statements)

References 38 publications

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“…Previous studies demonstrated that presence of carotid plaque was a more powerful predictor of cardiovascular events than intima-media thickness. [21][22][23][24] Carotid plaque score is useful as a means of semiquantitative analysis of degree of atherosclerosis. CPS is obtained by a wider range observation of the carotid arteries than intima-media thickness.…”

Section: Discussionmentioning

confidence: 99%

Impact of Combined Assessment of Coronary Artery Calcium Score, Carotid Artery Plaque Score, and Brachial-Ankle Pulse Wave Velocity for Early Coronary Revascularization in Patients With Suspected Coronary Artery Disease

et al. 2012

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SummaryCoronary artery calcium score (CACS) measured by multi-detector computed tomography, carotid plaque score (CPS) measured by carotid artery ultrasound, and brachial-ankle pulse wave velocity (baPWV) are noninvasive screening tools for coronary artery disease. The aim of this study was to determine whether the combination of CACS, CPS, and baPWV improves the prognostic value for future cardiac events. CACS, CPS, and baPWV were assessed in 77 patients (mean age, 65 years, 49 males) undergoing invasive coronary angiography. ECG-triggered MSCT was used to assess CACS. CPS was defined as the sum of all plaque heights in bilateral carotid arteries. The highest baPWV was used for analysis. Cardiac events were defined as cardiac death, nonfatal myocardial infarction, or coronary revascularization. Thirty-two cardiac events (41.6%) occurred during follow-up (23.6 ± 20.8 months), consisting of 28 PCIs and 4 CABGs. The best cutoff values of positive CACS, CPS, and baPWV for predicting cardiac events were ≥ 50, ≥ 5, and ≥ 1.6 m/ second, respectively. For the combination of the 3 modalities, the positive test was defined as having at least 1 positive result by each method. The negative predictive value of all 3 modalities combined was better than that of CACS alone. The event-free rate was higher in patients with negative results for all 3 parameters compared with those that were positive (100% versus 44.8%, P < 0.0001). The prognostic value of using combined assessment of CACS, CPS, and baPWV is more effective for predicting cardiac events than CACS alone. (Int Heart J 2012; 53: 154-159)

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Section: Discussionmentioning

confidence: 99%

Impact of Combined Assessment of Coronary Artery Calcium Score, Carotid Artery Plaque Score, and Brachial-Ankle Pulse Wave Velocity for Early Coronary Revascularization in Patients With Suspected Coronary Artery Disease

et al. 2012

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“…Adiponectin, the most abundant adipokine produced by adipocytes, provides an important association between obesity, insulin resistance, and related inflammatory disorders. Rundek et al found that adiponectin provides a small but significant contribution to variances in the carotid IMT 80) . Traditional cardiovascular risk factors explain only a small part of the variance observed in the carotid IMT.…”

Section: Associations Between the Carotid Imt And Biological Markersmentioning

confidence: 99%

Carotid Intima-Media Thickness for Atherosclerosis

Nezu

Hosomi

Aoki

et al. 2016

J Atheroscler Thromb

261

201

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“…The presence of carotid plaque and the carotid intima-media thickness (C-IMT) are known markers of subclinical or early atherosclerosis and are associated with an increased risk of cardiovascular disease in large epidemiological studies [1][2][3] . Associations between the progression of carotid plaque or C-IMT over time and cardiovascular events have also been reported 4,5) .…”

Section: Introductionmentioning

confidence: 99%