Carotid plaque morphology and risk for stroke.

Gomez, Camilo R.

doi:10.1161/01.str.21.1.148

Cited by 87 publications

(49 citation statements)

References 31 publications

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“…As for IMT, several authors have reported that the severity of carotid atherosclerosis as evaluated by ultrasonography is an useful indicator of the risk of ischemic stroke in symptomatic patients (21) and the coronary heart disease event rate (22). However, there are reports pointing out somewhat different results depending on the site or the method of measurement in the carotid artery (23).…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome and Carotid Atherosclerosis: Role of Elevated Blood Pressure

Kawamoto

Tomita

Oka

et al. 2005

JAT

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Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome and Carotid Atherosclerosis: Role of Elevated Blood Pressure

Kawamoto

Tomita

Oka

et al. 2005

JAT

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“…Large plaques consisting of many FCs and SMCs in the aorta and carotid artery bifurcation walls or many small fatty plaques in the carotid arteries possibly decrease the blood flow in the carotid arteries and are suspected of causing brain ishchemia and stroke [9,20,21,44].…”

Section: Diabetesmentioning

confidence: 99%

Aortic Atheromatous Lesions Developed in APA Hamsters with Streptozotocin induced Diabetes: A New Animal Model for Diabetic Atherosclerosis. 1. Histopathological Studies.

et al. 2000

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Abstract:To develop an adequate animal model for atherosclerosis in large vessels of patients with diabetes, i.e. diabetic macroangiopathy, we induced diabetes in APA hamsters with a single injection of streptozotocin (SZ) and examined the aorta histopathologically and immunohistochemically. As a result, hyperglycemia and hyperlipidemia were continuously observed for 26 weeks after the SZ injection (WAI) in APA hamsters. Fatty streaks characterized by a subendothelial accumulation of many foam cells were observed, limited to the aortic arches as early as 6 WAI. In addition to larger fatty streaks developing with the duration of diabetes, fibrous plaques and plaques containing calcium deposits or cholesterol clefts developed at 26 WAI. These lesions are generally similar to the atheromatous lesions developed in humans. Moreover, depositions of apolipoprotein E and advanced glycation end-products immunohistochemically detected in the lesions were very similar to those found in humans. The diabetic APA hamster is therefore considered to be a useful model for studying the formation of atheromatous lesions in diabetic patients. Key words: APA hamster, atheromatous lesion, diabetes, macroangiopathy small vessels (microangiopathy) [19,23,33,35]. On the other hand, appropriate animal models of diabetic complications in large vessels (macroangiopathy) are quite rare [18,34], even though macroangiopathy is a leading cause of death in diabetic patients [7,10,29,38].Syrian hamsters of the APA strain (APA hamsters) have been developed in Japan [40] and are known to

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“…[1][2][3] Few studies have quantified the association between carotid plaques and risk of subsequent stroke in asymptomatic subjects. 4,5 Also, limited information is available on the relationship with subtypes of cerebral infarction 4,5 as well as on the impact of location of the carotid plaque in relation to the risk of stroke.…”

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confidence: 99%

Carotid Plaques Increase the Risk of Stroke and Subtypes of Cerebral Infarction in Asymptomatic Elderly

et al. 2002

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Background-Few studies have quantified the relation between carotid plaques and stroke in asymptomatic patients, and limited data exist on the importance of location of plaques or the association with subtypes of cerebral infarction. We investigated the relationship between carotid plaques, measured at different locations, and risk of stroke and subtypes of cerebral infarction in a population-based study. Methods and Results-The study was based on the Rotterdam Study and included 4217 neurologically asymptomatic subjects aged 55 years or older. Presence of carotid plaques at 6 locations in the carotid arteries was assessed at baseline. Severity was categorized according to the number of affected sites. After a mean follow-up of 5.2 years, 160 strokes had occurred. Data were analyzed using Cox proportional hazards regression. Plaques increased the risk of stroke and cerebral infarction Ϸ1.5-fold, irrespective of plaque location. Severe carotid plaques increased the risk of nonlacunar infarction in anterior (RR 3.2 [95% CI, 1.1 to 9.7]) but not in posterior circulation (RR 0.6 [95% CI, 0.1 to 4.9]). A Ͼ10-fold increased risk of lacunar infarction was found in subjects with severe plaques (RR 10.8 [95% CI, 1.7 to 69.7]). No clear difference in risk estimates was seen between ipsilateral and contralateral infarction. Conclusions-Carotid plaques increase the risk of stroke and cerebral infarction, irrespective of their location. Plaques increase the risk of infarctions in the anterior but not in the posterior circulation. It is likely that carotid plaques in neurologically asymptomatic subjects are both markers of generalized atherosclerosis and sources of thromboemboli.

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Carotid plaque morphology and risk for stroke.

Cited by 87 publications

References 31 publications

Metabolic Syndrome and Carotid Atherosclerosis: Role of Elevated Blood Pressure

Metabolic Syndrome and Carotid Atherosclerosis: Role of Elevated Blood Pressure

Aortic Atheromatous Lesions Developed in APA Hamsters with Streptozotocin induced Diabetes: A New Animal Model for Diabetic Atherosclerosis. 1. Histopathological Studies.

Carotid Plaques Increase the Risk of Stroke and Subtypes of Cerebral Infarction in Asymptomatic Elderly

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