Carotid Plaque Stiffness Measured with Supersonic Shear Imaging and Its Correlation with Serum Homocysteine Level in Ischemic Stroke Patients

Shang, Juju; Wang, Wen; Feng, Jiaxuan; Luo, Gaoxing; Dang, Yujie; Sun, Jie; Yang, Yu-Hsuen; Ruan, Litao

doi:10.3348/kjr.2018.19.1.15

Cited by 18 publications

(33 citation statements)

References 33 publications

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“…All studies scored an unknown or high risk of bias in at least one category. Seven studies (Ramnarine et al 2014b;Garrard et al 2015;Li et al 2016;Zhang et al 2016;Alis et al 2018;Shang et al 2018;Marlevi et al 2020) did not report whether they included patients randomly or consecutively, and one study reported they did not (Marais et al 2019). In addition, most studies (Li et al 2016;Zhang et al 2016;Lou et al 2017;Marais et al 2019) did not report whether the index test was interpreted without knowledge of the reference standard and vice versa.…”

Section: Quality Assessmentmentioning

confidence: 99%

“…In addition, most studies (Li et al 2016;Zhang et al 2016;Lou et al 2017;Marais et al 2019) did not report whether the index test was interpreted without knowledge of the reference standard and vice versa. Additionally, multiple studies (Ramnarine et al 2014b;Zhang et al 2016;Lou et al 2017;Shang et al 2018) used echogenicity as a reference standard in assessment of plaque vulnerability. However, echogenicity provides only an indication of plaque composition; it does not absolutely assess it.…”

Section: Quality Assessmentmentioning

confidence: 99%

“…Di Leo et al (2018) did not mention any quantitative values measured by the index test, which complicates the assessment of whether its interpretation could have introduced bias. Finally, two studies (Ramnarine et al 2014b;Shang et al 2018) did not include all patients in the final analysis because of complete occlusion of the internal carotid artery (ICA) and presence of both hyper-and hypo-echoic plaques on the symptomatic side. Marais et al (2019) also did not include all patients in the final analysis but they argued that the included subpopulation was representative of the entire population.…”

Section: Quality Assessmentmentioning

confidence: 99%

“…The 10 studies on SWE in human carotid arteries (Ramnarine et al 2014b;Garrard et al 2015;Maksuti et al 2016;Zhang et al 2016;Lou et al 2017;Alis et al 2018;Di Leo et al 2018;Shang et al 2018;Marais et al 2019;Marlevi et al 2020) were performed with varying numbers of patients, that is, 22 (Marlevi et al 2020) to 199 (Zhang et al 2016); different diseases affecting the arterial wall, that is, Behçets disease (Alis et al 2018) and hypertension (Marais et al 2019); and different stages of atherosclerotic disease, that is, atherosclerotic plaques (Ramnarine et al 2014b;Zhang et al 2016;Lou et al 2017;Marlevi et al 2020), symptomatic patients with a CEA scheduled (Garrard et al 2015;Di Leo et al 2018) or without a CEA scheduled (Maksuti et al 2016;Shang et al 2018); and different methods of comparison, that is, pulse wave velocity (PWV) (Maksuti et al 2016;Marais et al 2019) and/or healthy controls (Ramnarine et al 2014b;Maksuti et al 2016;Alis et al 2018;Marais et al 2019) in the arterial wall, and plaque echogenicity (GSM) (Garrard et al 2015;Zhang et al 2016;Lou et al 2017;Shang et al 2018) Because not all patient groups present with atherosclerotic plaques, three studies solely investigated the carotid arterial wall (Maksuti et al 2016;Alis et al 2018;Marais et al 2019). Only one study...…”

Section: Study Characteristicsmentioning

confidence: 99%

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Vascular Shear Wave Elastography in Atherosclerotic Arteries: A Systematic Review

Pruijssen

Korte

Voss

et al. 2020

Ultrasound in Medicine & Biology

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Ischemic stroke is a leading cause of death and disability worldwide, so adequate prevention strategies are crucial. However, current stroke risk stratification is based on epidemiologic studies and is still suboptimal for individual patients. The aim of this systematic review was to provide a literature overview on the feasibility and diagnostic value of vascular shear wave elastography (SWE) using ultrasound (US) in (mimicked) human and non-human arteries affected by different stages of atherosclerotic diseases or diseases related to atherosclerosis. An online search was conducted on Pubmed, Embase, Web of Science and IEEE databases to identify studies using US SWE for the assessment of vascular elasticity. A quality assessment was performed using Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) checklist, and relevant data were extracted. A total of 19 studies were included: 10 with human patients and 9 with non-human subjects (i.e., [excised] animal arteries and polyvinyl alcohol phantoms). All studies revealed the feasibility of using US SWE to assess individually stiffness of the arterial wall and plaques. Quantitative elasticity values were highly variable between studies. However, within studies, SWE could detect statistically significant elasticity differences in patient/subject characteristics and could distinguish different plaque types with good reproducibility. US SWE, with its unique ability to assess the elasticity of the vessel wall and plaque throughout the cardiac cycle, might be a good candidate to improve stroke risk stratification. However, more clinical studies have to be performed to assess this technique's exact clinical value.

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Section: Quality Assessmentmentioning

confidence: 99%

Section: Quality Assessmentmentioning

confidence: 99%

Section: Quality Assessmentmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Vascular Shear Wave Elastography in Atherosclerotic Arteries: A Systematic Review

Pruijssen

Korte

Voss

et al. 2020

Ultrasound in Medicine & Biology

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show abstract

“…In recent years, shear wave-based elastography techniques, such as shear wave elastography (SWE) and shear wave dispersion (SWD) have received wide attention for noninvasive assessment of elasticity and viscidity properties [8, 9]. This study was to assess the carotid TS and viscoelasticity by ultrasonic technologies and explored the relationship between them.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound assessment of tensile stress in carotid arteries of healthy human subjects with varying age

Luo

2019

BMC Med Imaging

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BackgroundArterial remodeling is thought to reflect the adaptation of the vessel wall to mechanical and hemodynamic stimuli and contributes to the progression of cardiovascular and cerebrovascular diseases. Tensile stress (TS) is one of the mechanical properties of the artery wall. The purpose of this study was to investigate the tensile stress change (TS) of carotid artery with varying viscoelasticity in healthy subjects within two groups of different ages.MethodsForty-five subjects were recruited and randomly assigned into the group at the age above 50 years and below 50 years. The carotid arteries were examined by ultrasonography, using the techniques of shear wave elastography (SWE), shear wave dispersion (SWD) and radiofrequency (RF) -based ultrasound. The following values, including elastic modulus (SWER) and viscous index (SWDR), as well as the peak and mean TS of the left and right carotid arteries (L-PTS, R-PTS, L-MTS and R-MTS) were measured. The correlations between SWER, SWDR and tensile stress were evaluated.ResultsThe SWER and SWDR of carotid arteries are lower in the subjects ≥50 years old than the subjects younger than 50 years (SWER, 10.29 ± 9.57 kPa VS 17.24 ± 14.07 kPa; SWDR, 11.99 ± 3.51 (m/s)/kHz VS 13.97 ± 3.71 (m/s)/kHz, P < 0.05). The R-PTS was lower in the group with younger age (P < 0.05). Pearson correlation analysis showed that SWER of carotid artery was positively correlated with the parameters of tensile stress, R-PTS, R-MTS, L-PTS and L-MTS(r = 0.218, r = 0.359, r = 0.209 and r = 0.369, respectively, P < 0.05). However, SWDR of carotid arteries was not significantly associated with TS.ConclusionUltrasonic shear wave imaging could be used to quantitatively assess carotid viscoelasticity. The carotid TS was related to its elasticity while little related to its viscosity, suggesting that mechanical properties of the arterial wall might be better revealed.Trial registrationDate of our trial registration: 2018-06-11. Registered with the official website of China Clinical Trial Registration Center (ChiCTR1800016590)

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The association between hyperhomocysteinemia and the prevalence of bilateral carotid atherosclerotic plaques in a middle-aged population

Yong,

Dong,

Zhu

et al. 2024

Clinical Neurology and Neurosurgery

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Carotid Plaque Stiffness Measured with Supersonic Shear Imaging and Its Correlation with Serum Homocysteine Level in Ischemic Stroke Patients

Cited by 18 publications

References 33 publications

Vascular Shear Wave Elastography in Atherosclerotic Arteries: A Systematic Review

Vascular Shear Wave Elastography in Atherosclerotic Arteries: A Systematic Review

Ultrasound assessment of tensile stress in carotid arteries of healthy human subjects with varying age

The association between hyperhomocysteinemia and the prevalence of bilateral carotid atherosclerotic plaques in a middle-aged population

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