Carotid-radial pulse wave velocity responses following hyperemia in patients with congestive heart failure

Liu, Yang; Beck, Andrew F.; Olaniyi, Olawale; Singh, Sahib; Shehaj, Fiona; Mann, Ravi-Inder; Hassan, Syed R.; Kamran, Haroon; Salciccioli, Louis; Carter, John; Lazar, Jason

doi:10.1016/j.jash.2014.07.025

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…Two studies ( 74 , 85 ) measured carotid-radial PWV in addition to carotid-femoral PWV. This is considered to be a measure of peripheral artery stiffness but may also reflect endothelial function ( 92 , 93 ). In the meta-analysis, the carotid-femoral PWV results were used.…”

Section: Resultsmentioning

confidence: 99%

The effect of exercise on vascular health in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials

Davies,

Hughes,

Sandoo

et al. 2023

American Journal of Physiology-Renal Physiology

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Patients with chronic kidney disease (CKD) are at increased risk of cardiovascular disease. This increased risk cannot be fully explained by traditional risk factors such as hypertension. Endothelial dysfunction and arterial stiffness have been suggested as factors which explain some of the increased risk, and are independently associated with important cardiovascular outcomes in CKD patients. Studies in other disease populations have shown positive effects of exercise on vascular dysfunction. The aim of this review was to determine whether exercise training interventions improve measures of vascular function and morphology in patients across the spectrum of CKD and which exercise training interventions are most efficacious. A systematic search of Medline, Embase and the Cochrane Central Register identified 25 randomized, controlled trials. Only randomized control trials using an exercise intervention with non-exercising control group, and at least one measure of vascular function or morphology were included. Participants were non-dialysis CKD or transplant patients, or those requiring dialysis therapy. A systematic review was conducted according to PRISMA guidelines. A meta-analysis was completed for pulse wave velocity, augmentation index and measures of endothelial-dependent vasodilation. Data from 25 studies with 872 participants showed that exercise training reduced pulse wave velocity and augmentation index, but had no effect on vasodilation. Subgroup analyses suggested that exercise interventions of at least moderate intensity were more likely to be effective. Limitations included the absence observational studies, or other interventions aimed at increasing habitual physical activity. Further studies are warranted to investigate which are the most effective exercise interventions.

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Section: Resultsmentioning

confidence: 99%

The effect of exercise on vascular health in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials

Davies,

Hughes,

Sandoo

et al. 2023

American Journal of Physiology-Renal Physiology

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“…Because of higher smooth muscle content and increased vascular smooth muscle tone in the peripheral arteries, c-r PWV can reflect the functional aspect of arterial stiffness [ 45 ]. Moreover, c-r PWV can be recognized as a functional measure of arterial vasodilator reserve and maybe endothelial function [ 46 ]. Overall, increased central or peripheral arterial stiffness can indicate the arterial wall damage and the progression of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Ambulatory and successive home-based heart rate targeted aerobic training improves arterial parameters: a follow-up study in people with metabolic syndrome

Zupkauskiene,

Lauceviciene,

Ryliskyte

et al. 2023

Annals of Medicine

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Background Studies demonstrated that outpatient aerobic exercise programs (aEP) can significantly decrease aortic stiffness in people with metabolic syndrome (MetS). There is some limited data that remotely supervised home-based aEP can also improve arterial stiffness in this population. We aimed to evaluate the changes in the arterial wall parameters after the 2-month ambulatory supervised aEP followed by the 6-month home-based aEP with and without targeting of heart rate (HR) by electrocardiogram (ECG) in people with MetS. Methods In this prospective study (ClinicalTrials.gov identifier: NCT05592704) 132 MetS subjects (mean age 52.44 ± 6.26 years, 54.55% female) were evaluated. At first, all subjects participated in the 2-month ambulatory supervised aEP, which consisted of 40 individual aerobic training sessions on a cycle ergometer 5 times/week for 40 min and received the recommendations for home-based training. Then the study ( n = 66) and the control ( n = 66) groups participated in the 6-month home-based aEP, but only the study group subjects targeted their HR using ECG monitor connected to the smartphone during workouts. Arterial stiffness parameters and carotid artery intima-media thickness (cIMT) were evaluated in all participants at baseline and after 8 months. Results After 8 months, carotid-femoral pulse wave velocity (c-f PWV) significantly reduced in both groups (−12.22% in the study group vs. −7.85% in the control group, all p < .001) without a significant between-group difference ( p = 0.144). A significant improvement of carotid-radial pulse wave velocity (c-r PWV) was observed only in the study group (-11.37%, p < .001, d = −0.671) with significant between-group difference ( p < .001). The reduction of c-r PWV after 8 months of aEP occurred when c-r PWV at baseline was in the 2nd quartile (>7.90 m/s). A significant decrease of 3.32% in cIMT was present only in the study group ( p = .032, d = −0.288). Conclusions The combination of 2-month ambulatory supervised aEP and successive 6-month home-based aEP targeted by HR monitoring using ECG improved arterial properties in MetS subjects more than the same combination without HR targeting, leading to the greater reduction of c-r PWV and cIMT.

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“…Previous studies have examined potential differences in arterial stiffness between arms [2][3][4][5], with conflicting findings. Further, while the assessment of arterial stiffness can provide a snapshot of vascular health at rest, information on dynamic vascular function can be determined by assessing the change in Pulse Wave Velocity (PWV) in response to a condition of reactive hyperemia [6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Methodological Consideration for Endothelial Function Assessment based on Bilateral Differences

Holmstrup¹,

Keyser²,

Jensen³

2020

Artery Res

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Carotid-radial pulse wave velocity responses following hyperemia in patients with congestive heart failure

Cited by 5 publications

References 36 publications

The effect of exercise on vascular health in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials

The effect of exercise on vascular health in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials

Ambulatory and successive home-based heart rate targeted aerobic training improves arterial parameters: a follow-up study in people with metabolic syndrome

Methodological Consideration for Endothelial Function Assessment based on Bilateral Differences

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