2021
DOI: 10.1007/s10072-021-05629-w
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Carotid revascularization and cognitive impairment: the neglected role of cerebral small vessel disease

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Cited by 7 publications
(3 citation statements)
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“…The higher prevalence of intimal ICAC subtype in lacunar stroke patients could be partly attributed to the burden of vascular risk factors [16]. Vascular risk factors are the main determinants for development of atherosclerotic lesions associated with intimal calcifications, and may also lead to endothelial dysfunction, as previously demonstrated by the higher levels of specific biomarkers of this pathological process found in lacunar (i.e., subcortical) strokes compared to cortical strokes [17–19].…”
Section: Discussionmentioning
confidence: 97%
“…The higher prevalence of intimal ICAC subtype in lacunar stroke patients could be partly attributed to the burden of vascular risk factors [16]. Vascular risk factors are the main determinants for development of atherosclerotic lesions associated with intimal calcifications, and may also lead to endothelial dysfunction, as previously demonstrated by the higher levels of specific biomarkers of this pathological process found in lacunar (i.e., subcortical) strokes compared to cortical strokes [17–19].…”
Section: Discussionmentioning
confidence: 97%
“…The higher prevalence of intimal ICAC subtype in lacunar patients could be partly attributed to the higher burden of vascular risk factors [12], which may lead to endothelial dysfunction, as previously demonstrated by the higher levels of speci c biomarkers of this pathological process found in lacunar stroke compared to cortical stroke. [13][14][15] Endothelial dysfunction may eventually result in intimal lesions, such as calci cations, that could represent an epiphenomenon of the high burden of vascular risk factors, rather than culprit lesions.…”
Section: Discussionmentioning
confidence: 71%
“…With the changes in diet, atherosclerosis and its complications have increased and caused elevated morbidity and mortality worldwide ( 2 ). Atherosclerosis of the internal carotid artery, leading to narrowing of the vessel lumen by >50% of the original size, affects nearly 10% of the population above the age of 70 years and causes ~15% of ischemic strokes ( 3 ). According to the statistics of patients with carotid atherosclerosis, males are more prone to carotid atherosclerosis and the incidence rate of carotid atherosclerosis in males is higher than that in females ( 4 ).…”
Section: Introductionmentioning
confidence: 99%