Carotid Ultrasound Maximum Plaque Height–A Sensitive Imaging Biomarker for the Assessment of Significant Coronary Artery Disease

Johri, Amer M.; Behl, Pearl; Hétu, Marie-France; Haqqi, Mohammad; Ewart, Paul; Day, Andrew G.; Parfrey, Brendan; Matangi, M.

doi:10.1111/echo.13007

Cited by 57 publications

(38 citation statements)

References 29 publications

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“…9,11,12,22 A meta-analysis of 11 studies also supported this finding. 9,11,12,22 A meta-analysis of 11 studies also supported this finding.…”

Section: Discussionmentioning

confidence: 73%

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Predicting obstructive coronary artery disease using carotid ultrasound parameters: A nomogram from a large real‐world clinical data

Chen

et al. 2018

Eur J Clin Investigation

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“…9,11,12,22 A meta-analysis of 11 studies also supported this finding. 9,11,12,22 A meta-analysis of 11 studies also supported this finding.…”

Section: Discussionmentioning

confidence: 73%

“…with low frequency but severe risks. 12 However, few studies have focused on the total number of plaques. Atherosclerosis plays a key role in the pathogenesis of CAD.…”

Section: Introductionmentioning

confidence: 99%

Predicting obstructive coronary artery disease using carotid ultrasound parameters: A nomogram from a large real‐world clinical data

Chen

et al. 2018

Eur J Clin Investigation

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“…An evaluation of 500 ultrasound examinations carried out on patients 1 day prior to their undergoing a coronary angiogram revealed an 87% level of sensitivity in predicting a coronary stenosis of at least 50% following a type III or IV b ultrasound finding [1]. A further study which was conducted revealed similar results [7]. The follow-up study to date has demonstrated that subjects with advanced atherosclerosis (type III or type IV b findings) are at significantly increased risk of having cardiovascular disease.…”

Section: Discussionmentioning

confidence: 98%

Early Diagnosis and Treatment of Coronary Heart Disease in Symptomatic Subjects With Advanced Vascular Atherosclerosis of the Carotid Artery (Type III and IV b Findings Using Ultrasound)

2017

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BackgroundA study was conducted as to whether the early diagnosis of coronary heart disease (CHD) in symptomatic patients with advanced atherosclerosis of the carotid artery was more successful using ultrasound technology than exercise electrocardiography (ECG).MethodsWithin the scope of an occupational screening program using subjects from diverse employment sectors, people were given the opportunity to determine their risk of heart attack. During the study, the total plaque area (TPA), the maximum plaque thickness in the carotid artery and the PROCAM scores of 3,513 healthy men and 2,088 healthy women between the ages of 20 and 65 were determined. During the subsequent follow-up study, 36 subjects developed symptoms such as exertional dyspnea, atypical angina pectoris (AP) or typical AP. Four patients displayed no symptoms. The initial cardiac diagnostic testing was conducted on 31 patients using an exercise ECG, four patients were assessed using a coronary angiogram, and five further patients were assessed using a computed tomography (CT) coronary angiogram. An ultrasound examination of the carotid artery of 39 patients revealed a type IV b finding and in one patient, the examination revealed a type III finding.ResultsIn 17 patients, the PROCAM score was < 10%, 13 patients had a score of 10-20% and 10 patients had a score of > 20%. In the final analysis, only two patients had entirely smooth coronary arteries, seven had coronary sclerosis, seven had a 30% stenosis, one had a 30-40% stenosis, one had a 40% stenosis, and 22 patients had a stenosis ≥ 50%, and in extreme cases, a left main coronary artery stenosis with three-vessel disease was shown. The exercise ECG only achieved a true positive result in four patients, and in 21 patients, the result was false negative.ConclusionsSymptomatic patients with advanced atherosclerosis of the carotid artery (type III and type IV b findings) had a high risk for CHD. The diagnosis of CHD is better achieved by using carotid duplex than with an exercise ECG. Early treatment of the disease improves the patient’s prognosis.

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“…The CIMT was measured in the far wall distal CCA and the mean of both sides was used for analysis. Carotid plaque height was measured in the bulb and ICA as previously described, and the maximum of either side was used for analysis …”

Section: Methodsmentioning

confidence: 99%

“…The extent of CAD from angiography was quantified using a previously established angiographic score. 14,15 Briefly, a score of zero represented no coronary lesions, one represented mild disease (0-25% stenosis of at least one artery), two represented moderately significant disease (25-50% stenosis of at least one artery), and three represented severe disease (>50% stenosis of at least one artery). The high inter-rater reliability for this method was previously established by Johri and colleagues.…”

Section: Carotid Ultrasound and Speckle Tracking Strain Analysismentioning

confidence: 99%

Speckle tracking carotid artery circumferential strain is a marker of arterial sclerosis but not coronary atherosis

Patton

Hétu

et al. 2018

J of Clinical Ultrasound

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Carotid Ultrasound Maximum Plaque Height–A Sensitive Imaging Biomarker for the Assessment of Significant Coronary Artery Disease

Abstract: Increased carotid intima-media thickness and plaque measurements are indicative of the presence of epicardial coronary stenosis. Plaque burden is a more sensitive imaging biomarker for ruling out significant coronary artery disease, including in younger individuals.

Cited by 57 publications

References 29 publications

Predicting obstructive coronary artery disease using carotid ultrasound parameters: A nomogram from a large real‐world clinical data

Predicting obstructive coronary artery disease using carotid ultrasound parameters: A nomogram from a large real‐world clinical data

Early Diagnosis and Treatment of Coronary Heart Disease in Symptomatic Subjects With Advanced Vascular Atherosclerosis of the Carotid Artery (Type III and IV b Findings Using Ultrasound)

Speckle tracking carotid artery circumferential strain is a marker of arterial sclerosis but not coronary atherosis

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