Carpal Tunnel Syndrome and Diabetes—A Comprehensive Review

Zimmerman, Malin; Gottsäter, Anders; Dahlin, Lars B.

doi:10.3390/jcm11061674

Cited by 32 publications

(28 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, in our database most patients with a diagnosis received surgical treatment. Economic well-being seems to be crucial in CTS since a low economic well-being is related to higher comorbidity burden [12], such as diabetes in which nerves are more susceptible to nerve compression [27,28]. There is also evidence that both type of occupation as well as level of educational achievement are important for development of clinically relevant CTS [7].…”

Section: Discussionmentioning

confidence: 99%

Carpal Tunnel Syndrome and Ulnar Nerve Entrapment Are Associated with Impaired Psychological Health in Adults as Appraised by Their Increased Use of Psychotropic Medication

Dahlin

Perez

Nyman

et al. 2022

JCM

Self Cite

View full text Add to dashboard Cite

We aimed to study psychological health, as approximated by the use of psychotropic drugs, in a population diagnosed and surgically treated for carpal tunnel syndrome (CTS) or ulnar nerve entrapment (UNE), or both, also considering the demographic and socioeconomic factors of the individuals. Linking data from five large national registers, use of psychotropics (at least one dispensation during the first year after the surgery or the baseline date) was examined in around 5.8 million people 25–80 years old residing in Sweden 2010. Among these individuals, 9728 (0.17%), 890 (0.02%) and 149 (0.00%) were identified as diagnosed and surgically treated for CTS, UNE, or both, respectively. As much as 28%, 34% and 36% in each group, respectively, used psychotropic drugs, compared with 19% in the general population. Regression analyses showed a general higher risk for use of psychotropics related to these nerve compression disorders, to higher age, being a woman, and having low income or low occupational qualification level. Individuals born outside of Sweden had a lower risk. We conclude that surgically treated individuals with a nerve compression disorder have an increased risk of impaired psychological health. Caregivers should be aware of the risk and provide necessary attention.

show abstract

Section: Discussionmentioning

confidence: 99%

Carpal Tunnel Syndrome and Ulnar Nerve Entrapment Are Associated with Impaired Psychological Health in Adults as Appraised by Their Increased Use of Psychotropic Medication

Dahlin

Perez

Nyman

et al. 2022

JCM

Self Cite

View full text Add to dashboard Cite

show abstract

“…There are several other possible explanations for why hyperglycaemia increases the risk of developing EN [ 22 ]. High levels of blood glucose prompt the mitochondria in the nerve cell to produce reactive oxygen species that cause damage to the nerve [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Diabetic retinopathy as a predictor for peripheral compression neuropathies, a registry-based study

2022

Self Cite

View full text Add to dashboard Cite

Diabetes is characterized by hyperglycaemia and entails many complications, including retinopathy and entrapment neuropathies, such as ulnar nerve entrapment (UNE) and carpal tunnel syndrome (CTS). Hyperglycaemia damages the nerves of the retina, as well as peripheral nerves. There is a correlation between entrapment neuropathies and retinopathy in patients with diabetes, but whether patients with diabetic retinopathy are more prone to develop CTS and UNE is uncertain. Hence, the aim was to investigate if retinopathy can be used as a factor predicting the development of CTS and UNE. Data from 95,437 individuals from the National Diabetes Registry were merged with data from the Skåne Healthcare Registry. The population was analysed regarding prevalence of CTS or UNE and retinopathy status. Population characteristics were analysed using the Chi2-test, Student’s Independent T-test, and the Mann-Whitney U-test. Two logistic regression models were used to analyse the odds ratio (OR) for development of CTS and UNE depending on retinopathy status, adjusted for possible confounders. Both CTS and UNE were more frequent among those with retinopathy, compared to those without (CTS: 697/10,678 (6.5%) vs. 2756/83,151 (3.3%; p<0.001), (UNE: 131/10,678 (1.2%) vs. 579/83,151 (0.7%; p<0.001)). The OR for developing CTS for individuals with type 1 diabetes and retinopathy was 2.40 (95% CI 2.06–2.81; p<0.001) and of developing UNE was 1.53 (0.96–2.43; p = 0.08). The OR for developing CTS for individuals with type 2 diabetes and retinopathy was 0.93 (0.81–1.08; p = 0.34) and for UNE 1.02 (0.74–1.40; p = 0.90). Diabetic retinopathy is associated with a higher risk of developing CTS and UNE, but the association seems to be mediated by the duration of the diabetes. Higher HbA1c levels, longer diabetes duration and higher BMI are significant risk factors for developing CTS and UNE in type 1 and type 2 diabetes.

show abstract

“…Even data from skin biopsies of fingers in vibration-exposed workers indicate that there is a reduction in content of calcitonin gene-related peptide as well as intraepidermal nerve fibre density observed as staining for PGP-9.5 in the biopsies 6. The structural changes in the peripheral nerve may also induce an increased susceptibility for peripheral nerve compression syndromes, like carpal tunnel syndrome (CTS),7 in accordance with the relation between diabetic neuropathy and CTS 8 9. The aim of the present observational study was to examine several nerve-related biomarkers, as a sign of neuropathy that can be measured in plasma in a cohort of subjects who were exposed to hand-held vibrating tools.…”

Section: Introductionmentioning

confidence: 95%

Exposure to hand-held vibrating tools and biomarkers of nerve injury in plasma: a population-based, observational study

2023

Self Cite

View full text Add to dashboard Cite

ObjectivesTo analyse potential biomarkers for vibration-induced nerve damage in a population-based, observational study.DesignProspective cohort study.SettingMalmö Diet Cancer Study (MDCS), Malmö, Sweden.ParticipantsIn a subcohort of 3898 individuals (recruited 1991–1996) from MDCS (baseline examination in 28 449 individuals; collection of fasting blood samples in a cardiovascular subcohort of MDCS of 5540 subjects), neuropathy-relevant plasma biomarkers were analysed during follow-up after filling out questionnaires, including a question whether work involved hand-held vibrating tools, graded as ‘not at all’, ‘some’ or ‘much’.Primary outcome measuresThe neuropathy-relevant plasma biomarkers vascular endothelial growth factor (VEGF)-A, VEGF-D, VEGF receptor 2, galanin, galectin-3, HSP27, ß-nerve growth factor, caspase-3, caspase-8, transforming growth factor-α and tumour necrosis factor were analysed. Data were analysed by conventional statistics (Kruskal-Wallis test; post hoc test Mann-Whitney U test; Bonferroni correction for multiple testing) and in a subanalysis for galanin using two linear regression models (unadjusted and adjusted).ResultsAmong participants, 3361 of 3898 (86%) reported no work with hand-held vibrating tools, 351 of 3898 (9%) reported some and 186 of 3898 (5%) much work. There were more men and smokers in vibration-exposed groups. Galanin levels were higher after much vibration exposure (arbitrary units 5.16±0.71) compared with no vibration exposure (5.01±0.76; p=0.015) with no other observed differences.ConclusionsHigher plasma levels of galanin, possibly related to magnitude, frequency, acceleration and duration, as well as to severity of symptoms of vibration exposure, may be found in individuals working with hand-held vibrating tools.

show abstract

Carpal Tunnel Syndrome and Diabetes—A Comprehensive Review

Cited by 32 publications

References 109 publications

Carpal Tunnel Syndrome and Ulnar Nerve Entrapment Are Associated with Impaired Psychological Health in Adults as Appraised by Their Increased Use of Psychotropic Medication

Carpal Tunnel Syndrome and Ulnar Nerve Entrapment Are Associated with Impaired Psychological Health in Adults as Appraised by Their Increased Use of Psychotropic Medication

Diabetic retinopathy as a predictor for peripheral compression neuropathies, a registry-based study

Exposure to hand-held vibrating tools and biomarkers of nerve injury in plasma: a population-based, observational study

Contact Info

Product

Resources

About