Carpal Tunnel Syndrome in Children With Mucopolysaccaridoses

Yuen, Alex; Dowling, Guy J; Johnstone, Brian M.; Kornberg, Andrew J.; Coombs, Christopher J.

doi:10.1177/0883073807300528

Cited by 56 publications

(61 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In such cases, carpal tunnel syndrome probably develops because of a combination of factors, such as excessive lysosomal storage in the connective tissue of the flexor retinaculum and anatomic changes caused by bone dysplasia. 1,9 Although lysosomal disorders are the most common cause of carpal tunnel syndrome in children, in our group a lysosomal storage disease was diagnosed in only 1 patient (case 6). This could be explained by the neuromuscular patient profile in our department.…”

Section: Discussionmentioning

confidence: 83%

Carpal Tunnel Syndrome in Children

et al. 2013

View full text Add to dashboard Cite

Carpal tunnel syndrome rarely occurs in children. We retrospectively analyzed clinical data of 11 patients aged 5-17 diagnosed with carpal tunnel syndrome at a single pediatric neuromuscular center. Nerve conduction studies were performed according to the American Association of Electrodiagnostic Medicine recommendations. Additional imaging tests of the wrist were performed in 10 patients. In our group of 11 children, carpal tunnel syndrome was idiopathic in only 1 case. In the remaining subjects, it was secondary to congenital bone anomaly (6), hypothyroidism (2), or myopathic contractures (1). In 1 case, metabolic workup revealed an underlying mucopolysaccharidosis. Our results confirm that idiopathic carpal tunnel syndrome is rare in children. Hand clumsiness and thenar hypoplasia rather than sensory complaints are the presenting symptoms. Whenever carpal tunnel syndrome is diagnosed in a child, a thorough differential diagnosis should be made because of the secondary nature of this disease in most pediatric patients.

show abstract

Section: Discussionmentioning

confidence: 83%

Carpal Tunnel Syndrome in Children

et al. 2013

View full text Add to dashboard Cite

show abstract

“…4,5 Children may present with symptoms of carpal tunnel syndrome in a manner different from what is typical in adults. They may not necessarily have thenar atrophy 6 and cannot always describe pain or paresthesias accurately. In some cases, children present with automutilation as a result of median neuropathy.…”

Section: Discussionmentioning

confidence: 99%

Missed Childhood-Onset Carpal Tunnel Syndrome Diagnosed as Chronic Pain: Case Report

Wong

Horowitz²,

Watson³

et al. 2012

The Journal of Hand Surgery

View full text Add to dashboard Cite

“…While CTS is associated with a number of systemic diseases and some mechanical and occupational factors (Mattioli et al 2009;Uchiyama et al 2010), a genetic predisposition for CTS has also been shown (Hakim et al 2002;Lozano-Calderon et al 2008). CTS presenting in childhood should prompt consideration of an underlying lysosomal storage disorder or other genetic condition (Van Meir and De Smet 2003;Sri-Ram et al 2007;Yuen et al 2007). Patients presenting to Australian general practice with symptoms of CTS are predominantly female (male-female ratio 2 : 3) and 46% are aged 45-65 years (Charles et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Carpal Tunnel Syndrome in Fabry Disease

et al. 2011

View full text Add to dashboard Cite

Carpal tunnel syndrome (CTS) is a common peripheral mononeuropathy affecting up to 4% of the general population, typically women in late middle age. The incidence in patients with Fabry disease (FD) is unclear, but may affect 25% of patients with this X-linked lysosomal storage disease. We report three cases of CTS in young Caucasian male patients with classical FD, who developed CTS symptoms with supportive nerve conduction study (NCS) findings. Two patients had bilateral CTS and two had evidence of concurrent ulnar nerve neuropathy on NCS, suggesting a systemic process contributed to nerve compression. All were receiving enzyme replacement therapy (ERT) and had a moderate burden of FD complications. It is possible that an increase in connective tissue in the intracarpal canal in FD patients may be incited by injury to fibroblasts, via either accumulation of globotriaosylceramide (GL3) or local ischaemia through endothelial injury. The former hypothesis may be a more plausible explanation for the development of CTS, as histology of the flexor retinaculae from our patients has demonstrated fibroblasts with characteristic vacuolation and excessive myxomatous stroma, despite endothelial clearance of GL3 in these patients receiving ERT. CTS should not be overlooked in FD patients and young patients presenting with CTS should be evaluated for an underlying systemic or genetic disorder. Surgical carpal tunnel decompression was effective in our patients, already troubled by long-standing acroparesthesia, in providing sustained relief of symptoms.

show abstract

Carpal Tunnel Syndrome in Children With Mucopolysaccaridoses

Cited by 56 publications

References 10 publications

Carpal Tunnel Syndrome in Children

Carpal Tunnel Syndrome in Children

Missed Childhood-Onset Carpal Tunnel Syndrome Diagnosed as Chronic Pain: Case Report

Carpal Tunnel Syndrome in Fabry Disease

Contact Info

Product

Resources

About