Summary:The aim of this study was to determine the anatomical structures in carpal region with the routine T1, T2 weighted (W) and three-dimensional (3D) magnetic resonance (MR) sequences that are frequently being used for the diagnosis and the treatment of the wrist disorders and to indicate the efficacy of MR imaging (MRI) on the rabbit's carpal region which can be a convenient wrist model especially for the carpal tunnel syndrome. It is also aspired to compare the image features obtained from 1.5 and 3 Tesla MR units in terms of anatomy and radiology. Five adult New Zealand rabbits were used in this study. Wrists were scanned in neutral position by 1.5 and 3 Tesla MR devices with a loop coil and a 15-channel transmit-receive birdcage coil respectively. Anatomy of the carpal tunnel was well defined in T1W transverse images in 1.5 Tesla MRI. The median nerve was imaged with greater signal intensity on T2W sequences. In 3 Tesla MRI, the anatomical structures in carpal region could easily be evaluated on high resolution 3D sequences with isotropic voxels and also with the help of thin section reformatted images. According to our results, 3D sequences with isotropic voxel sizes by 15-channel transmit-receive birdcage coil in 3 Tesla MRI device seems to be more efficient than the other routine two-dimensional sequences in 1.5 Tesla MRI for the assessment of carpal tunnel anatomy, diagnosis and treatment of disorders both in humans and in animals. This process also decreases the MRI time and specific absorption rate (SAR) values.