Carrageenan and its applications in drug delivery

Li, Liang; Ni, Rui; Shao, Yang; Mao, Shirui

doi:10.1016/j.carbpol.2013.12.008

Cited by 507 publications

(245 citation statements)

References 128 publications

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“…Lack of biosignaling compounds and empty voids will eventually reduce the cell density and distribution of cells throughout the cell culture process [4]. Therefore, these pores should be filled with soft material like hydrogel in order to assist the cell growth and at the same time 2 International Journal of Polymer Science increase the cells density without losing too much of them in the growth media [5].…”

Section: Introductionmentioning

confidence: 99%

“…Natural-based hydrogel like carrageenan has been chosen as the best candidate due to the unique features found in its molecular structures such as unique mechanism of gelation, ability to absorb high water content, abundant negative charges, functional groups that can be easily modified accordingly, and great chemical and proteins delivery for the tissue regeneration [6]. In fact, it is not just good for the infused material but it also has good therapeutic properties such as anticancer, antiviral, anticoagulation, and antihyperlipidaemia properties [5]. Nowadays, carrageenan is often used as the matrix polymer in the production of controlled drug release tablets and stabilizer in the system of microparticles as it extends medicine shelf-life.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy Study of Carrageenan as an Alternative Infused Material (Filler) in Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Porous 3D Scaffold

Johari

Aizad

Zubairi

2017

International Journal of Polymer Science

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Polymeric porous 3D scaffold plays an important role in culturing mammalian cells as ex vivo model. However, the scaffold used is ineffective due to its structural and cell acceptability weaknesses. Therefore, this research attempts to overcome the weaknesses by using carrageenan from red seaweed Kappaphycus alvarezii as an alternative infused material (filler) of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) porous 3D scaffold. The 3D scaffold was conventionally fabricated using the solvent-casting particulateleaching (SCPL) method. Carrageenan was later infused into 3D porous scaffolds under vacuum pressure and freeze-drying process. Five carrageenan concentrations were prepared and its physicochemical properties such as pH and viscosity were carried out on each concentration to determine the best solutions to produce a new composite 3D structure. The preliminary result shows that carrageenan concentrations of 2, 4, and 6% (w/v) were considered the best solutions for the infusion process due to its stable rheology properties. The pH and viscosity profiles of three selected carrageenan solutions were exhibited in the range of 9.00-9.20 and 0.047-1.144 Pa⋅s, respectively. Moreover, the incorporated carrageenan gel fraction was in the range of 4.30% to 14.95% (w/w) which was determined by gravimetric analysis and dye staining method (visual assessment). The well-infused carrageenan 3D scaffold was further characterized based on its internal morphology and degradability study. The vertical cross-sections of the scaffolds revealed homogeneous accumulation of dried gelatinous carrageenan which was covered throughout its pores wall. The degradation rate ( ) of the carrageenan infused 3D scaffold was between 0.01 ± 1.66 (mg/day) and 0.03 ± 3.23 (mg/day). The higher the carrageenan concentration used, the faster the degradation rate occurring ( < 0.05). The 3D infused scaffold of 4% (w/v) carrageenan concentration (S2) produced a moderate degradation rate of 0.02 ± 1.55 (mg/day) with a sustained structural integrity up to 28 days. The carrageenan infused scaffold of 4% (w/v) was demonstrated to be the best 3D structure for a long-term cell culture (>2 weeks). In conclusion, the usage of carrageenan as a composite material exhibits its great potential to be used in tissue engineering application and 3D cell culture model.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy Study of Carrageenan as an Alternative Infused Material (Filler) in Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Porous 3D Scaffold

Johari

Aizad

Zubairi

2017

International Journal of Polymer Science

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“…They are abundant, biodegradable natural polymers that can be used to produce micro-or nanocapsules and hydrogels with the aim of reducing pesticide use and toxicity, thus protecting both the environment and human health (25) . Among the main polysaccharides, carrageenan is highlighted for its biodegradability and capability to form hydrogels (26) (27) . The aim of this study was to develop a controlled-release device of biodegradable polysaccharide-based formulation and with a cotton thread containing standardized extract of P. nigrum, to be used in small water storage containers to control the A. aegypti larvae.…”

Section: Introductionmentioning

confidence: 99%

A biodegradable device for the controlled release of Piper nigrum (Piperaceae) standardized extract to control Aedes aegypti (Diptera, Culicidae) larvae

Custódio

Oliveira

Moterle

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction:The signifi cant increase in dengue, Zika, and chikungunya and the resistance of the Aedes aegypti mosquito to major insecticides emphasize the importance of studying alternatives to control this vector. The aim of this study was to develop a controlled-release device containing Piper nigrum extract and to study its larvicidal activity against Aedes aegypti. Methods: Piper nigrum extract was produced by maceration, standardized in piperine, and incorporated into cotton threads, which were inserted into hydrogel cylinders manufactured by the extrusion of carrageenan and carob. The piperine content of the extract and thread reservoirs was quantifi ed by chromatography. The release profi le from the device was assessed in aqueous medium and the larvicidal and residual activities of the standardized extract as well as of the controlled-release device were examined in Aedes aegypti larvae. Results: The standardized extract contained 580mg/g of piperine and an LC 50 value of 5.35ppm (24h) and the 3 cm thread reservoirs contained 13.83 ± 1.81mg of piperine. The device showed zero-order release of piperine for 16 days. The P. nigrum extract (25ppm) showed maximum residual larvicidal activity for 10 days, decreasing progressively thereafter. The device had a residual larvicidal activity for up to 37 days. Conclusions: The device provided controlled release of Piper nigrum extract with residual activity for 37 days. The device is easy to manufacture and may represent an effective alternative for the control of Aedes aegypti larvae in small water containers.

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“…Similarly, it is feasible by intelligent manipulation of polysaccharides to prepare systems that are responsive to environmental parameters (e.g., pH). Such systems can be used for drug delivery at locations where pH discrepancies may occur (e.g., along the gastrointestinal tract) [5]. Controlling the particle size of the delivery system is one of the most important and challenging factors that need to be addressed when designing such systems.…”

Section: Introductionmentioning

confidence: 99%

The parallel lives of polysaccharides in food and pharmaceutical formulations

Kontogiorgos¹,

Smith²,

Morris³

2015

Current Opinion in Food Science

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The present opinion article discusses how polysaccharide structures can be used in both food and pharmaceutical formulations. We distinguish two regions depending on moisture content where polysaccharides form structures with distinct functional properties. Some trends in key areas of active research are assessed and in particular edible films, encapsulation, polycrystalline polysaccharides, protein-polysaccharide coacervation and fluid gels. We unveil that the physicochemical principles that are shared across the food and pharmaceutical disciplines provide a great opportunity for crossdisciplinary collaboration. We finally argue that such co-operation will help tackling polysaccharide functionality issues that are encountered in both areas.3

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Carrageenan and its applications in drug delivery

Cited by 507 publications

References 128 publications

Efficacy Study of Carrageenan as an Alternative Infused Material (Filler) in Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Porous 3D Scaffold

Efficacy Study of Carrageenan as an Alternative Infused Material (Filler) in Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Porous 3D Scaffold

A biodegradable device for the controlled release of Piper nigrum (Piperaceae) standardized extract to control Aedes aegypti (Diptera, Culicidae) larvae

The parallel lives of polysaccharides in food and pharmaceutical formulations

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