Carrel's cultures

Witkowski, J. A.

doi:10.1126/science.247.4949.1385-a

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Dissenting Evidence 3: Primary Rodent Cells Readily Immortal...1

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2005

2022

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“…Carrel and his associates Burrows and Ebeling had since the 1910's presented a series of publications claiming their successful in vitro immortalization of chick embryonic fibroblasts by continuing adding chick embryo extracts into the culture of chick embryonic heart tissue, although many contemporaries questioned this world's first success in transforming cells in vitro [252][253][254][255]. Nevertheless, there have since 1940's been many studies showing that in vitro culture can easily transform primary cells of small rodent origins [71], especially the hamster and mouse [256][257][258][259][260], as the cultured cells can form tumors when injected into syngeneic animals.…”

Section: Dissenting Evidence 3: Primary Rodent Cells Readily Immortal...mentioning

confidence: 99%

Mutation or not, what directly establishes a neoplastic state, namely cellular immortality and autonomy, still remains unknown and should be prioritized in our research

Zhu¹,

Wang²,

Zellmer³

et al. 2022

J. Cancer

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Section: Dissenting Evidence 3: Primary Rodent Cells Readily Immortal...mentioning

confidence: 99%

Mutation or not, what directly establishes a neoplastic state, namely cellular immortality and autonomy, still remains unknown and should be prioritized in our research

Zhu¹,

Wang²,

Zellmer³

et al. 2022

J. Cancer

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Bridging the gap: ageing, pharmacokinetics and pharmacodynamics

Burton

Allen

Bird

et al. 2005

Journal of Pharmacy and Pharmacology

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Changes in pharmacokinetics and pharmacodynamics in elderly patients generally result in an increase in the incidence of drug toxicity and adverse drug reactions. Molecular alterations associated with ageing could bring about biological changes, a consequence of which is an altered response to pharmacological agents. Unfortunately, research in this area has yet to progress beyond the cataloguing of the pharmacokinetic and pharmacodynamic changes observed in the elderly. Therefore, real progress in our understanding of pharmacogerontology could be achieved if it were possible to merge pharmacokinetic and pharmacodynamic studies with recent advances in our understanding of the causal processes bringing about ageing changes at the cellular level. Therefore, this review will focus on the mechanisms of ageing in the hope that the information will be of value to those planning independent studies.

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Carrel's cultures

Cited by 2 publications

References 1 publication

Mutation or not, what directly establishes a neoplastic state, namely cellular immortality and autonomy, still remains unknown and should be prioritized in our research

Mutation or not, what directly establishes a neoplastic state, namely cellular immortality and autonomy, still remains unknown and should be prioritized in our research

Bridging the gap: ageing, pharmacokinetics and pharmacodynamics

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