Carriage of Multidrug-Resistant Bacteria in Healthy People: Recognition of Several Risk Groups

Neut, Christel

doi:10.3390/antibiotics10101163

Cited by 13 publications

(9 citation statements)

References 44 publications

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“…The receptor for stx2 is globotriosyl ceramide which is seen in both swine and humans [ 43 ]. Also, the LT and ST gene was detected both in isolates from swine (29 isolates, 45.3%) and patients (11 isolates, 22.0%), which is associated with neonatal or postweaning diarrhea in pigs and in traveler’s diarrhea in humans [ 44 , 45 ]. There was no common fimbrial adhesin in isolates from both swine and patients.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial resistance, virulence genes, and phylogenetic characteristics of pathogenic Escherichia coli isolated from patients and swine suffering from diarrhea

Seo

Lee

2022

BMC Microbiol

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Background Escherichia (E.) coli causes colibacillosis in swine and humans, and is frequently associated with antimicrobial resistance. In this study we aimed to compare antimicrobial resistance, O-serogroups, virulence genes, and multi-locus sequence type of E. coli between isolates from pigs and patients suffering from diarrhea, and the most prevalent pathogenic E. coli strain from swine isolates in Korea. Methods We tested 64 and 50 E. coli strains from pigs and patients suffering from diarrhea for antimicrobial susceptibility test, virulence genes, O-serogroups, and multi-locus sequence typing. Results We confirmed that isolates from swine showed significantly higher resistance than from those from patients, especially to fluoroquinolone (ciprofloxacin: 37.5 and 10.0%; norfloxacin: 29.7 and 8.0%, respectively). Stx1 (46.0%) was most frequently detected in patients followed by stx2 (38.0%). There was no significant difference in stx2 (swine: 23.4%, patients: 38.0%). In isolates from patients, O157 (12.0%) was the most prevalent O-serogroup, and two isolates (3.1%) from pigs were confirmed to have O157. Additionally, sequence type (ST) 10 (swine: 6 isolates, patients: 2 isolates) and ST 88 (swine: 2 isolates, patients: 1 isolate) were simultaneously detected. Conclusions We found that both isolates from swine and human had the stx2 gene, which could cause severe disease. Moreover, antimicrobial resistance was significantly higher in pigs than in patients. These results suggest that pig could act as a reservoir in human infection and antimicrobial resistance could be transferred to human from pigs.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial resistance, virulence genes, and phylogenetic characteristics of pathogenic Escherichia coli isolated from patients and swine suffering from diarrhea

Seo

Lee

2022

BMC Microbiol

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“…These MDR bacteria include Staphylococcus aureus , Klebsiella pneumoniae , Streptococcus pneumoniae , Escherichia coli , Acinetobacter baumannii , Pseudomonas aeruginosa , Vibrio parahaemolyticus , Salmonella Typhimurium, Enterococcus faecium , Enterococcus faecalis , Enterobacter spp., etc. [ 36 , 42 , 43 ]. Day by day many other bacteria also increasingly becoming resistant to antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Coated Polymeric Silver and Gold Nanoparticles: Biosynthesis, Characterization and Potential Antibacterial Applications: A Review

et al. 2022

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Biosynthesized metal nanoparticles, especially silver and gold nanoparticles, and their conjugates with biopolymers have immense potential in various fields of science due to their enormous applications, including biomedical applications. Polymeric nanoparticles are particles of small sizes from 1 nm to 1000 nm. Among different polymeric nanoparticles, chitosan-coated silver and gold nanoparticles have gained significant interest from researchers due to their various biomedical applications, such as anti-cancer, antibacterial, antiviral, antifungal, anti-inflammatory technologies, as well as targeted drug delivery, etc. Multidrug-resistant pathogenic bacteria have become a serious threat to public health day by day. Novel, effective, and safe antibacterial agents are required to control these multidrug-resistant pathogenic microorganisms. Chitosan-coated silver and gold nanoparticles could be effective and safe agents for controlling these pathogens. It is proven that both chitosan and silver or gold nanoparticles have strong antibacterial activity. By the conjugation of biopolymer chitosan with silver or gold nanoparticles, the stability and antibacterial efficacy against multidrug-resistant pathogenic bacteria will be increased significantly, as well as their toxicity in humans being decreased. In recent years, chitosan-coated silver and gold nanoparticles have been increasingly investigated due to their potential applications in nanomedicine. This review discusses the biologically facile, rapid, and ecofriendly synthesis of chitosan-coated silver and gold nanoparticles; their characterization; and potential antibacterial applications against multidrug-resistant pathogenic bacteria.

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“…39,40 Many other risk factors were identified to increase the incidence of MDR even in people as carriers, such as travel history to areas endemic with MDR, health occupations, comorbidities including DM and inflammatory bowel disease, immunosuppressive drugs and chemotherapy, AIDS, cystic fibrosis and extreme of ages. [41][42][43][44] Nowadays, worldwide measures are taken to decrease the risk for MDR. 45,46 In the present study, most of the isolates with MDR were Acinetobacter baumannii, which can present into three distinct clinical entities.…”

Section: Discussionmentioning

confidence: 99%

Acute Kidney Injury Among Patients with Multi-Drug Resistant Infection: A Study from Jordan

Oweis¹,

Zeyad²,

Alshelleh³

et al. 2022

JMDH

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Background: Acute kidney injury (AKI) is a well-known complication for hospitalized patients. Sepsis and various infections play a significant role in increasing the incidence of AKI. The present study evaluated the risk for Multidrug-resistant (MDR) infections and its effect on the incidence of AKI, hospitalization, need for dialysis, and mortality. Methods: In a retrospective study design, data were collected from all adult patients with a positive multi-drug resistant culture who were admitted to King Abdullah University Hospital (KAUH). Records of 436 patients were reviewed between January 2017 -December 2018 with at least one year of follow-up. Results: The mean age was 57.3 years (SD± 23.1), and 58.5% were males. The most common source of positive cultures was sputum, with 50% positive cultures. The incidence of AKI was 59.2%. The most isolated microorganism was Acinetobacter baumannii (76.8%), followed by Pseudomonas aeruginosa (14.9%).On multivariate analysis, age (OR 1.1, 95% CI 1.1-1.2, P=0.001), HTN (OR 1.8, 95% CI 1.0-3.3, P=0.02), DM (OR 1.1, 95% CI 0.6-1.9, P=0.69) and the use of Foley catheter on chronic bases (OR 4.3, 95% CI 2.6-6.8, P<0.0001) were strong predictors of AKI. Among patients with AKI, 74.4% died compared to 44.4% among non-AKI patients (p<0.001). Conclusion:In patients with MDR, AKI incidence, hospitalization, and mortality were high. Early detection and addressing the problem may decrease bad outcomes, and health education for reducing antibiotic abuse is needed to lower MDR.

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Carriage of Multidrug-Resistant Bacteria in Healthy People: Recognition of Several Risk Groups

Cited by 13 publications

References 44 publications

Antimicrobial resistance, virulence genes, and phylogenetic characteristics of pathogenic Escherichia coli isolated from patients and swine suffering from diarrhea

Antimicrobial resistance, virulence genes, and phylogenetic characteristics of pathogenic Escherichia coli isolated from patients and swine suffering from diarrhea

Chitosan-Coated Polymeric Silver and Gold Nanoparticles: Biosynthesis, Characterization and Potential Antibacterial Applications: A Review

Acute Kidney Injury Among Patients with Multi-Drug Resistant Infection: A Study from Jordan

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