Carrier‐bound fibrin sealant compared to oxidized cellulose application after liver resection

Zacharias, Thomas; Ferreira, Nelio

doi:10.1111/j.1477-2574.2012.00560.x

Cited by 20 publications

(17 citation statements)

References 29 publications

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“…For comparison, the perioperative transfusion rate in 133 consecutive liver resection procedures (all types) performed between Nov. 9, 2007, and Nov. 2, 2011, in our institution was 43%. 28 Furthermore, the mean blood loss of 914 mL in the present study is within the range reported by other authors. 16,39,40 …”

Section: Discussionsupporting

confidence: 78%

“…28 Right hepatectomy (odds ratio [OR] 7.8, 95% confidence interval [CI] 2.8-21.2) and repeat hepatectomy (OR 6.1, 95% CI 1.7-21.6) were identified as predictors of blood loss greater than 500 mL in multivariate analysis. For blood loss greater than 1000 mL, only right hepatectomy was a significant risk factor in multivariate analysis (OR 5.6, 95% CI 1.8-16.9).…”

Section: Predictors Of Blood Lossmentioning

confidence: 99%

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Intraoperative cell salvage with autologous transfusion in elective right or repeat hepatectomy: a propensity-score–matched case–control analysis

Zacharias

Ahlschwede

Dufour

et al. 2018

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Section: Discussionsupporting

confidence: 78%

Section: Predictors Of Blood Lossmentioning

confidence: 99%

Intraoperative cell salvage with autologous transfusion in elective right or repeat hepatectomy: a propensity-score–matched case–control analysis

Zacharias

Ahlschwede

Dufour

et al. 2018

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“…In our study, bleeding after hemostasis and mean first postoperative day blood drainage volume in TachoSil were significantly lower than Surgicel. However, Zacharias and Ferreira [17] found a similar complication rate and mean hospital stay in TachoSil and Surgicel groups; however, TachoSil group had a little higher hospital stay and less major complications. This study did not recognize any of them superior to the other.…”

Section: Discussionmentioning

confidence: 95%

A Randomized Clinical Trial Comparing the Effect of Different Haemostatic Agents for Haemostasis of the Liver after Hepatic Resection

et al. 2013

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Introduction. Operative blood loss is still a great obstacle to liver resection, and various topical hemostatic agents were introduced to reduce it. The aim of the current study is to evaluate effects of 3 different types of these agents. Methods. In this randomized clinical trial, 45 patients undergoing liver resection were assigned to receive TachoSil, Surgicel, and Glubran 2 for controlling bleeding. Intraoperative and postoperative findings were compared between groups. Results. Postoperative bleeding (0 versus 33.3%, P = 0.04) and drainage volume first day after surgery (281.33 ± 103.98 versus 150.00 ± 60.82 mL, P = 0.02) were significantly higher in Surgicel than in TachoSil group. Postoperative complications included bile leak (3 cases in Surgicel, 1 case in TachoSil and Glubran 2), noninfectious collection (2 cases in TachoSil and Surgicel and 1 case in Glubran 2), perihepatic abscess, and massive hematoma around hepatectomy site both in Surgicel group. There was no death during the study period. Conclusion. Due to higher complications in Surgicel group, its application as hemostatic agent after liver resection is not recommended. Better results in TachoSil in comparison to the other two are indicative of its better efficacy and superiority in controlling hemostasis.

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“…The full text of the remaining 33 articles were assessed for eligibility and reviewed in detail: 11 papers were excluded because not pertinent with liver surgery. From 1993 to 2016 we found 22 full‐text article studies , included in this systematic review for qualitative synthesis: among them, 13 combining FMT or MT or FM were included for quantitative meta‐analysis (Table ).…”

Section: Resultsmentioning

confidence: 99%

An update on topical haemostatic agents in liver surgery: systematic review and meta analysis

Brustia

Granger

Scatton

2016

J Hepatobiliary Pancreat Sci

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Mortality and morbidity in hepatic surgery are affected by blood loss and transfusion. Topical haemostatic agents (THA) are composed by a matrix and/or fibrin sealants, and their association known as "carrier-bound fibrin sealant" (CBFS): despite widely used for secondary haemostasis, the level of evidence remains low. To realize a meta-analysis on the results of CBFS on haemostasis and postoperative complications. Searches in PubMed, PubMed Central, Cochrane and Google Scholar using keywords: "topical_haemostasis" OR "haemostatic_agents" OR "sealant_patch" OR "fibrin_sealant" OR "collagen_sealant" AND "liver_surgery" OR "hepatic_surgery" OR "liver_transplantation". Randomized clinical trials, large retrospective cohort studies, case control studies evaluating THA on open/laparoscopic liver surgery and transplantation. From 1993 to 2016 were found 22 studies for qualitative synthesis and 13 for quantitative meta-analysis. The time to haemostasis was lower in the CBFS group (mean difference À2.33 min; P = 0.00001). The risk of receiving blood transfusion, developing collections and bile leak was not influenced by the use of CBFS (OR 0.75; P = 0.25), (OR 0.72; P = 0.52), (OR 0.74; P = 0.30) respectively. The use of CBFS in liver surgery significantly reduce the time to haemostasis, but does not decrease transfusion, postoperative collection and bile leak.

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Carrier‐bound fibrin sealant compared to oxidized cellulose application after liver resection

Abstract: The results of the present study suggest that the routine use of TachoSil after a liver resection does not reduce the overall complication rate compared with Surgicel application. However, TachoSil may be beneficial in a major hepatectomy.

Cited by 20 publications

References 29 publications

Intraoperative cell salvage with autologous transfusion in elective right or repeat hepatectomy: a propensity-score–matched case–control analysis

Intraoperative cell salvage with autologous transfusion in elective right or repeat hepatectomy: a propensity-score–matched case–control analysis

A Randomized Clinical Trial Comparing the Effect of Different Haemostatic Agents for Haemostasis of the Liver after Hepatic Resection

An update on topical haemostatic agents in liver surgery: systematic review and meta analysis

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