Carrier-Free Microspheres of an Anti-Cancer Drug Synthesized via a Sodium Catalyst for Controlled-Release Drug Delivery

Xie, Yiyang; Ma, Xinxin; Liu, Xujie; Long, Qingming; Wang, Yu; Yao, Youwei; Cai, Qiang

doi:10.3390/ma11020281

Cited by 10 publications

(5 citation statements)

References 41 publications

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“…Cancer is a severe threat to human life and causes more than seven million deaths each year [1]. Despite some technical breakthroughs that have been explored in cancer therapy, a reliable cure is still limited to such conventional methods as surgery, chemotherapy and radiotherapy [2,3]. In recent years, photothermal ablation therapy, which employs photothermal conversion agents to absorb near infrared (NIR) light and converts it into heat to ablate cancer cells, provides a highly efficient antitumor strategy for cancer therapy [4,5].…”

Section: Introductionmentioning

confidence: 99%

Photothermal Ablation of Cancer Cells by Albumin-Modified Gold Nanorods and Activation of Dendritic Cells

Wang

Naoki

et al. 2018

Materials

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Nanoparticle-mediated photothermal therapy has been widely studied for cancer treatment. It is important to disclose how photothermally ablated tumor cells trigger immune responses. In this study, bovine serum albumin (BSA)-coated gold nanorods (BSA-coated AuNRs) were prepared and used for photothermal ablation of breast tumor cells. The BSA-coated AuNRs showed high photothermal conversion efficiency and good photothermal ablation effect towards tumor cells. The ablated tumor cells were co-cultured with immature dendritic cells (DCs) through a direct cell contacting model and diffusion model to confirm the stimulatory effects of cell–cell interaction and soluble factors released from ablated tumor cells. The results indicated that photothermally ablated tumor cells induced immune-stimulatory responses of DCs through both cell–cell interaction and soluble factors. The results should be useful for synergistic photothermal-immunotherapy of primary and metastatic cancer.

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Section: Introductionmentioning

confidence: 99%

Photothermal Ablation of Cancer Cells by Albumin-Modified Gold Nanorods and Activation of Dendritic Cells

Wang

Naoki

et al. 2018

Materials

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“…The poor aqueous solubility of anticancer drugs results in poor efficacy or requires the use of excipients that have toxic side effects. Attempts have been made to solve the problem of poor aqueous solubility of antitumor drugs, such as the use of prodrugs, polymeric nanoparticles, lipoid microspheres, solubilizers, and nanocolloids [ 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. However, these attempts are limited by a number of problems such as instability, the potential toxicity of the compounds, the altered distribution of the drug in the body, and so on [ 47 , 48 ].…”

Section: Resultsmentioning

confidence: 99%

Water-Soluble Salts Based on Benzofuroxan Derivatives—Synthesis and Biological Activity

Chugunova

Matveeva

Tulesinova

et al. 2022

IJMS

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A series of novel water-soluble salts of benzofuroxans was achieved via aromatic nucleophilic substitution reaction of 4,6-dichloro-5-nitrobenzofuroxan with various amines. The salts obtained showed good effectiveness of the pre-sowing treatment of seeds of agricultural crops at concentrations of 20–40 mmol. In some cases, the seed treatment with salts leads not only to improved seed germination, but also to the suppression of microflora growth. Additionally, their anti-cancer activityin vitrohas been researched. The compounds with morpholine fragments or a fragment of N-dimethylpropylamine, demonstrated the highest cytotoxic activity, which is in good correlation with the ability to inhibit the glycolysis process in tumor cells. Two compounds 4e and 4g were selected for further experiments using laboratory animals. It was found that the lethal dose of 50% (LD50) is 22.0 ± 1.33 mg/kg for 4e and 13.75 ± 1.73 mg/kg for 4g, i.e., compound 4e is two times less toxic than 4g, according to the mouse model in vivo. It was shown that the studied compounds exhibit antileukemia activity after a single intraperitoneal injection at doses from 1.25 to 5 mg/kg, as a result of which the average lifespan of animals with a P388 murine leukemia tumor increases from 20 to 28%. Thus, the water-soluble salts of benzofuroxans can be considered as promisingcandidates for further development, both as anti-cancer agents and as stimulants for seed germination and regulators of microflora crop growth.

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“…Gold (Au) nanocrystal shape is also a critical factor in determining its chemical and physical properties. The topological features of Au nanocrystals affect the anisotropic electrical and optical responses more than those of spherical nanocrystals [ 5 ]. Gold nanorods and gold nanospheres are used as contrast agents for tumor imaging.…”

Section: Introductionmentioning

confidence: 99%

Gold Nanorods for Doxorubicin Delivery: Numerical Analysis of Electric Field Enhancement, Optical Properties and Drug Loading/Releasing Efficiency

et al. 2022

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The optical properties and electric field enhancement of gold nanorods for different cases were investigated in this study. The numerical analysis was carried out to understand the functionality and working of gold nanorods, while the experimental portion of the work was focused on the efficiency of gold nanorods for targeted drug delivery. COMSOL Multiphysics was used for numerical analysis. The theoretical results suggest the use of gold nanorods (AuNRs) for anticancer applications. The resonance peaks for gold nanorods of 10 nm diameter were observed at 560 nm. The resonance peaks shifted towards longer wavelengths with an increase in nanorod size. The resonance peaks showed a shift of 140 nm with a change in nanorod length from 25 to 45 nm. On the experimental side, 22 nm, 35 nm and 47 nm long gold nanorods were produced using the seed-mediated growth method. The surface morphology of the nanorods, as well as their optical characteristics, were characterized. Later, gold nanorods were applied to the targeted delivery of the doxorubicin drug. Gold nanorods showed better efficiency for doxorubicin drug loading time, release time, loading temperature, and release temperature. These results reveal that AuNRs@DA possess good ability to load and deliver the drug directly to the tumorous cells since these cells show high temperature and acidity.

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Carrier-Free Microspheres of an Anti-Cancer Drug Synthesized via a Sodium Catalyst for Controlled-Release Drug Delivery

Cited by 10 publications

References 41 publications

Photothermal Ablation of Cancer Cells by Albumin-Modified Gold Nanorods and Activation of Dendritic Cells

Photothermal Ablation of Cancer Cells by Albumin-Modified Gold Nanorods and Activation of Dendritic Cells

Water-Soluble Salts Based on Benzofuroxan Derivatives—Synthesis and Biological Activity

Gold Nanorods for Doxorubicin Delivery: Numerical Analysis of Electric Field Enhancement, Optical Properties and Drug Loading/Releasing Efficiency

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