Carrier-free nano-integrated strategy for synergetic cancer anti-angiogenic therapy and phototherapy

Zheng, Wei; Liang, Pingping; Xie, Junqi; Song, Chuanhui; Tang, Chuanchao; Wang, Yufeng; Yin, Xiteng; Cai, Yu; Han, Wei; Dong, Xiaochen

doi:10.1039/c8sc04123g

Cited by 93 publications

(58 citation statements)

References 60 publications

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“…[27,28] Moreover, excipients are essential for preparing drugloaded nanoparticles, which cause unsatisfied drug loading ratios. [35][36][37] Chemical modification of the small molecular therapeutics are essential for developing conventional excipientfree nanoparticles, which might impair the therapeutic performance of the anticancer drugs. [31][32][33][34] Most of current excipientfree nanomedicines have been designed as prodrug structures to self assemble into nanoformulations.…”

mentioning

confidence: 99%

Enhancing Triple Negative Breast Cancer Immunotherapy by ICG‐Templated Self‐Assembly of Paclitaxel Nanoparticles

Feng

Niu

Hou

et al. 2019

Adv Funct Materials

161

115

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Combination cancer immunotherapy has shown promising potential for simultaneously eliciting antitumor immunity and modulating the immunosuppressive tumor microenvironment (ITM). However, combination immunotherapy with multiple regimens suffers from the varied chemophysical properties and inconsistent pharmacokinetic profiles of the different therapeutics. To achieve tumor-specific codelivery of the immune modulators, an indocyanine green (ICG)-templated self-assembly strategy for preparing dual drug-loaded two-in-one nanomedicine is reported. ICG-templated self-assembly of paclitaxel (PTX) nanoparticles (ISPN), and the application of ISPN for combination immunotherapy of the triple negative breast cancer (TNBC) are demonstrated. The ISPN show satisfied colloidal stability and high efficacy for tumor-specific codelivery of ICG and PTX through the enhanced tumor permeability and retention effect. Upon laser irradiation, the ICG component of ISPN highly efficiently induces immunogenic cell death of the tumor cells via activating antitumor immune response through photodynamic therapy. Meanwhile, PTX delivered by ISPN suppresses the regulatory T lymphocytes (T regs ) to combat ITM. The combination treatment of TNBCwith ISPN and αPD-L1-medaited immune checkpoint blockade therapy displays a synergistic effect on tumor regression, metastasis inhibition, and recurrence prevention. Overall, the ICG-templated nanomedicine may represent a robust nanoplatform for combination immunotherapy.

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mentioning

confidence: 99%

Enhancing Triple Negative Breast Cancer Immunotherapy by ICG‐Templated Self‐Assembly of Paclitaxel Nanoparticles

Feng

Niu

Hou

et al. 2019

Adv Funct Materials

161

115

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“…Nanomaterial-based phototherapies that can selectively kill cancer cells without normal tissue injury have attracted extensive interest in the field of cancer treatments 69-71. Enhanced antitumor efficacy was also observed when angiogenesis inhibitors and phototherapy agents were combined 31, 72. For example, Kim and coworkers developed a hybrid RNAi-based AuNP nanoscale assembly (RNAi-AuNP) for combined antiangiogenesis gene therapy and photothermal ablation (Figure 2) 31.…”

Section: Nanomedicine-mediated Cancer Starvation Therapymentioning

confidence: 99%

“…After intratumoral administration, the therapeutic effects of PEI/RNAi-AuNP complexes could be activated by continuous-wavelength lasers or high intensity focused ultrasound, which led to effective antiangiogenesis and tumor ablation. In another work, a carrier-free nanodrug was prepared by self-assembling of Sorafenib and chlorin e6 (Ce6) for antiangiogenesis and photodynamic therapy 72. This nanodrug presented good passive targeting behavior in the tumor sites and effective reactive oxygen species (ROS) generation ability in vivo .…”

Section: Nanomedicine-mediated Cancer Starvation Therapymentioning

confidence: 99%

Advances in nanomedicine for cancer starvation therapy

et al. 2019

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Abnormal cell metabolism with vigorous nutrition consumption is one of the major physiological characteristics of cancers. As such, the strategy of cancer starvation therapy through blocking the blood supply, depleting glucose/oxygen and other critical nutrients of tumors has been widely studied to be an attractive way for cancer treatment. However, several undesirable properties of these agents, such as low targeting efficacy, undesired systemic side effects, elevated tumor hypoxia, induced drug resistance, and increased tumor metastasis risk, limit their future applications. The recent development of starving-nanotherapeutics combined with other therapeutic methods displayed the promising potential for overcoming the above drawbacks. This review highlights the recent advances of nanotherapeutic-based cancer starvation therapy and discusses the challenges and future prospects of these anticancer strategies.

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“…A significant amount of effort is, therefore, devoted to the design of high‐loading drug carriers [1] . Approaches can include carrier‐free strategies, where the drug is conjugated to another bioactive agent such as a photosensitizer and then processed into nanoparticles [1b, 2] . Alternatively, drug loading contents of more than 50 wt % have been observed with various mesoporous nanoparticles, [1a] metal‐organic frameworks, [3] polymer‐drug conjugates, [4] and polymeric micelles [5] .…”

Section: Filling Up the Trojan Horse With Drugs—maximizing Drug Loadingmentioning

confidence: 99%

The Trojan Horse Goes Wild: The Effect of Drug Loading on the Behavior of Nanoparticles

Stenzel

2020

Angewandte Chemie

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Drug delivery with nanoparticles is sometimes compared to an attack with a Trojan Horse. The drugs are hidden in nanoparticles and enter the unsuspecting cells in a stealth‐like fashion. Here, I would like to share my thoughts that a comparison to the Trojan Horse does not always apply, and provide examples where an increased drug loading content was detrimental to the drug‐delivery process. The purpose is to highlight the importance of understanding the physicochemical properties of nanoparticles, and the importance of having materials scientists in the line‐up of researchers working together to create successful nanomedicine.

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Carrier-free nano-integrated strategy for synergetic cancer anti-angiogenic therapy and phototherapy

Abstract: Herein, a nano-integrated strategy was used to combine an anti-angiogenic agent sorafenib and a photosensitizer chlorin e6 to form carrier-free multifunctional nanoparticles (SC NPs) for synergetic anti-angiogenic therapy and phototherapy.

Cited by 93 publications

References 60 publications

Enhancing Triple Negative Breast Cancer Immunotherapy by ICG‐Templated Self‐Assembly of Paclitaxel Nanoparticles

Enhancing Triple Negative Breast Cancer Immunotherapy by ICG‐Templated Self‐Assembly of Paclitaxel Nanoparticles

Advances in nanomedicine for cancer starvation therapy

The Trojan Horse Goes Wild: The Effect of Drug Loading on the Behavior of Nanoparticles

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