Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification

Recent advances in the targeted delivery of paclitaxel nanomedicine for cancer therapy

“…PTX nanomedicines have different physicochemical properties, such as decreased size, increased surface area, chemical modification and adjustable properties, and high reactivity. 155 However, although these nanomaterials have obvious benefits in therapeutic systems and cancer treatment, they are not without limitations in terms of highly unsafe in vivo reactions. The variability and ambiguity of processes happening at the nanobio interfaces, and also the lack of understanding regarding the underlying toxicity effects of nanomaterials have delayed the authorization of nanoscale-designed products.…”

Research progress on self-assembled nanodrug delivery systems

“…35 In addition to the advantages mentioned above, vector-free nanomaterials also show excellent flexibility and variability. 36 By optimizing the key characteristics of nanomaterials, such as size, shape, surface chemistry and long-term stability, they can be internalized more effectively, and their clinical safety can be improved so that they can be timely applied in clinical practice. 37 Depending on their composition, DSDSs can be divided into two categories: drug–polymer conjugates and pure drug–drug self-assembled nanodrug systems.…”

How Nanotechniques Could Vitalize the O-GlcNAcylation-Targeting Approach for Cancer Therapy

“… 28 Moreover, the carrier-free type of nanoparticles formed by self-assembly of one or multiple drugs can avoid the adverse effects caused by nanomaterials, which provides an obvious advantage. 29 …”