Carrier-free nanomedicines self-assembled from palbociclib dimers and Ce6 for enhanced combined chemo-photodynamic therapy of breast cancer

Huang, Zheng; Hu, Huaisong; Xian, Tong; Xu, Zhigang; Tang, Dianyong; Wang, Bochu; zhang, yimei

doi:10.1039/d2ra05932k

Cited by 8 publications

(14 citation statements)

References 38 publications

(50 reference statements)

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“…These results were consistent with PDT. Ce6 rapidly produced ROS under 660 nm laser irradiation, interacted with biomolecules in cancer cells, destroyed its structure, and eventually led to tumor cell death. , …”

Section: Resultsmentioning

confidence: 99%

“…The observed phenomena can be attributed to several factors. First, Ce6 photosensitizer produces ROS under 660 nm laser irradiation, which causes damage to cell membrane, mitochondria, and so forth, and cooperates with PTX-induced tumor cell death. ,, Second, Ce6 accelerated the cleavage of the conjugated double bond of the polymer PEG-OE-L, thereby increasing the release of PTX and Ce6 in liposomes. In addition, Dr-lips improved the solubility, cell uptake, and overall drug efficacy of Ce6.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, 660 nm was chosen as the excitation wavelength to enhance the effect of PDT. 36,40 As displayed in Figure 2B, lutein and PEG-OE-L could produce excited states and undergo photodynamic degradation at 405 nm, and the degradation rate exceeds 96% after 1 h of irradiation. In contrast, there were only trace amounts of degradation products at NIR light (660 nm).…”

Section: Synthesis Of Peg-oe-lmentioning

confidence: 99%

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Lutein-Based pH and Photo Dual-Responsive Novel Liposomes Coated with Ce6 and PTX for Tumor Therapy

Shen,

Zhang,

Wang

et al. 2023

ACS Omega

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Liposomes are considered the best nanocarrier for delivering cancer drugs such as chlorin e6 (Ce6) and paclitaxel (PTX). However, the poor stability and non-selectivity release of liposomes may severely limit their further applications. In this study, based on the characteristics of lutein (L) photo-response and orthoester (OE) acid-response, stable and dual-responsive liposomes (Dr-lips) have been prepared. The Dr-lips exhibited a spherical shape with a uniform size of approximately 58.27 nm. Moreover, they displayed a zeta potential ranging from −45.45 to −28.25 mV and showed excellent storage stability, indicating stable colloidal properties. Additionally, they achieved high drug encapsulation rates, with 92.27% for PTX and 90.34% for Ce6, respectively. Meanwhile, under near-infrared (NIR) light at 660 nm, Ce6 plays a key role in accelerating the photodegradation rate of lutein and PEG-OE-L while also enhancing tissue penetration ability. Additionally, Dr-lips loaded with Ce6 and PTX not only displayed excellent pH and photo dual-responsiveness for targeted delivering and releasing but also showed remarkable reactive oxygen species (ROS) generation capacity and impressive anti-tumor activity in vitro. Therefore, it provides a novel strategy for optimizing stability and enhancing their targeted drug delivery of liposome.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Synthesis Of Peg-oe-lmentioning

confidence: 99%

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Lutein-Based pH and Photo Dual-Responsive Novel Liposomes Coated with Ce6 and PTX for Tumor Therapy

Shen,

Zhang,

Wang

et al. 2023

ACS Omega

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“…The liposomal system was 1.63-fold more cytotoxic and had 1.45-fold increased AUC tot relative to free PLB . Moreover, Huang et al developed a dimeric prodrug of the PLB linked with a thioketal bond (reactive oxygen species responsive) and co-loaded with Ce6 for combined chemo-photodynamic therapy of triple-negative breast cancers . Apart from these, tumor hypoxia has displayed a key role in breast cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

“…27 Moreover, Huang et al developed a dimeric prodrug of the PLB linked with a thioketal bond (reactive oxygen species responsive) and co-loaded with Ce6 for combined chemo-photodynamic therapy of triple-negative breast cancers. 28 Apart from these, tumor hypoxia has displayed a key role in breast cancer therapy. Hypoxic breast tumors are highly aggressive, prone to metastasis, and resistant to anticancer drug treatment.…”

Section: ■ Introductionmentioning

confidence: 99%

Chitosan-g-estrone Nanoparticles of Palbociclib Vanished Hypoxic Breast Tumor after Targeted Delivery: Development and Ultrasound/Photoacoustic Imaging

Mehata

Singh

Vikas

et al. 2023

ACS Appl. Mater. Interfaces

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Breast cancer is the leading cause of death among women globally. Approximately 80% of all breast cancers diagnosed are overexpressed with estrogen receptors (ERs). In this study, we have developed an estrone (Egen)-grafted chitosan-based polymeric nanocarrier for the targeted delivery of palbociclib (PLB) to breast cancer. The nanoparticles (NPs) were prepared by solvent evaporation using the ionic gelation method and characterized for particle size, zeta potential, polydispersity, surface morphology, surface chemistry, drug entrapment efficiency, cytotoxicity assay, cellular uptake, and apoptosis study. The developed PLB-CS NPs and PLB-CS-g-Egen NPs had a particle size of 116.3 ± 1.53 nm and 141.6 ± 1.97 nm, respectively. The zeta potential of PLB-CS NPs and PLB-CS-g-Egen NPs was found to be 18.70 ± 0.416 mV and 12.45 ± 0.574 mV, respectively. The morphological analysis demonstrated that all NPs were spherical in shape and had a smooth surface. An in vitro cytotoxicity assay was performed in estrogen receptor (ER)-expressing MCF7 cells and T47D cells, which suggested that targeted NPs were 57.34-and 30.32-fold more cytotoxic compared to the pure PLB, respectively. Additionally, cell cycle analysis confirmed that cell cycle progression from the G1 into S phase was blocked more efficiently by targeted NPs compared to nontargeted NPs and PLB in MCF7 cells. In vivo pharmacokinetic studies demonstrated that entrapment of the PLB in the NPs improved the half-life and bioavailability by ∼2−3-fold. Further, ultrasound and photoacoustic imaging of DMBA induced breast cancer in the Sprague-Dawley (SD) rat showed that targeted NPs completely vanished breast tumor, reduced hypoxic tumor volume, and suppressed tumor angiogenesis more efficiently compared to the nontargeted NPs and free PLB. Further, in vitro hemocompatibility and histopathology studies suggested that NPs were biocompatible and safe for clinical use.

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Ce6 nanoassemblies: Molecular mechanism and strategies for combinational anticancer therapy

Liu,

Xu,

Lyu

et al. 2023

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Nowadays, cancer has become the leading cause of death worldwide, driving the need for effective therapeutics to improve patient prognosis. Photodynamic therapy (PDT) has been widely applied as an antitumor modality, owing to its minimal invasiveness, localized tumor damage, and high safety profile. However, its efficacy is limited by poor stability of photosensitizers, inadequate tumor accumulation, and a complex tumor microenvironment. To overcome these challenges, extensive endeavors have been made to explore the co‐assembly of the widely used photosensitizer chlorin e6 (Ce6) with various functional small molecules to enhance pharmacodynamic activity. This review provides a comprehensive overview of current studies on Ce6‐based nanoparticles for effective PDT and precise delivery of functional molecules. The self‐assembly mechanism will be discussed in detail, with a focus on potential strategies for combinational therapy with PDT.

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Carrier-free nanomedicines self-assembled from palbociclib dimers and Ce6 for enhanced combined chemo-photodynamic therapy of breast cancer

Abstract: A carrier-free nanomedicine self-assembled from palbociclib dimers and Ce6 for enhanced combined chemo-photodynamic therapy of breast cancer.

Cited by 8 publications

References 38 publications

Lutein-Based pH and Photo Dual-Responsive Novel Liposomes Coated with Ce6 and PTX for Tumor Therapy

Lutein-Based pH and Photo Dual-Responsive Novel Liposomes Coated with Ce6 and PTX for Tumor Therapy

Chitosan-g-estrone Nanoparticles of Palbociclib Vanished Hypoxic Breast Tumor after Targeted Delivery: Development and Ultrasound/Photoacoustic Imaging

Ce6 nanoassemblies: Molecular mechanism and strategies for combinational anticancer therapy

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