Carrier in carrier: Catanionic vesicles based on amphiphilic cyclodextrins complexed with DNA as nanocarriers of doxorubicin

Alarcón, Liliana P.; Andrada, Heber E.; Olivera, Marı́a Eugenia; Silva, O. Fernando; Falcone, R. Darío

doi:10.1016/j.molliq.2022.119488

Cited by 9 publications

(5 citation statements)

References 72 publications

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“…Therefore, there is an urgent need to develop drug delivery systems for therapeutic sites with limited side effects. The Alarcon team [ 134 ] conducted research to assess the interaction between Modified Cyclodextrin-Based Hollow Vesicles (ModCBHD) vesicles based on cyclodextrins and the DNA–DOX complex as a carrier for anticancer drugs. An example of such a combination is presented in the illustration below ( Figure 5 ).…”

Section: Nucleic-acid-based Drug Delivery Systemsmentioning

confidence: 99%

“…Therefore, there is an urgent need to develop drug delivery systems for therapeutic sites with limited side effects. The Alarcon team [134] conducted research to assess the interaction between Modified Cyclodextrin-Based Hollow Vesicles (ModCBHD) vesicles based on cyclodextrins The role of DNA in drug carriers, especially in nanotechnology, is becoming increasingly significant. Using DNA-based materials to construct drug carriers aims to improve therapeutic effectiveness and minimize side effects [128].…”

Section: Nucleic-acid-based Drug Delivery Systemsmentioning

confidence: 99%

See 1 more Smart Citation

Biomaterials in Drug Delivery: Advancements in Cancer and Diverse Therapies—Review

Drabczyk,

Kudłacik-Kramarczyk,

Jamroży

et al. 2024

IJMS

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Nano-sized biomaterials are innovative drug carriers with nanometric dimensions. Designed with biocompatibility in mind, they enable precise drug delivery while minimizing side effects. Controlled release of therapeutic substances enhances efficacy, opening new possibilities for treating neurological and oncological diseases. Integrated diagnostic-therapeutic nanosystems allow real-time monitoring of treatment effectiveness, which is crucial for therapy personalization. Utilizing biomaterials as nano-sized carriers in conjunction with drugs represents a promising direction that could revolutionize the field of pharmaceutical therapy. Such carriers represent groundbreaking drug delivery systems on a nanometric scale, designed with biocompatibility in mind, enabling precise drug delivery while minimizing side effects. Using biomaterials in synergy with drugs demonstrates significant potential for a revolutionary impact on pharmaceutical therapy. Conclusions drawn from the review indicate that nano-sized biomaterials constitute an innovative tool that can significantly improve therapy effectiveness and safety, especially in treating neurological and oncological diseases. These findings should guide researchers towards further studies to refine nano-sized biomaterials, assess their effectiveness under various pathological conditions, and explore diagnostic-therapeutic applications. Ultimately, these results underscore the promising nature of nano-sized biomaterials as advanced drug carriers, ushering in a new era in nanomedical therapy.

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Section: Nucleic-acid-based Drug Delivery Systemsmentioning

confidence: 99%

“…Therefore, there is an urgent need to develop drug delivery systems for therapeutic sites with limited side effects. The Alarcon team [134] conducted research to assess the interaction between Modified Cyclodextrin-Based Hollow Vesicles (ModCBHD) vesicles based on cyclodextrins The role of DNA in drug carriers, especially in nanotechnology, is becoming increasingly significant. Using DNA-based materials to construct drug carriers aims to improve therapeutic effectiveness and minimize side effects [128].…”

Section: Nucleic-acid-based Drug Delivery Systemsmentioning

confidence: 99%

Biomaterials in Drug Delivery: Advancements in Cancer and Diverse Therapies—Review

Drabczyk,

Kudłacik-Kramarczyk,

Jamroży

et al. 2024

IJMS

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“…This system showed great stability over a long period, small particle size, excellent drug loading capability, and strong, controlled release ability. These facts could be exploited to take advantage of EPR effects and decrease the side effects of DOX [ 132 ].…”

Section: Sirna Nanocarriersmentioning

confidence: 99%

Research Status and Prospect of Non-Viral Vectors Based on siRNA: A Review

Tong

Liu

Cao

et al. 2023

IJMS

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Gene therapy has attracted much attention because of its unique mechanism of action, non-toxicity, and good tolerance, which can kill cancer cells without damaging healthy tissues. siRNA-based gene therapy can downregulate, enhance, or correct gene expression by introducing some nucleic acid into patient tissues. Routine treatment of hemophilia requires frequent intravenous injections of missing clotting protein. The high cost of combined therapy causes most patients to lack the best treatment resources. siRNA therapy has the potential of lasting treatment and even curing diseases. Compared with traditional surgery and chemotherapy, siRNA has fewer side effects and less damage to normal cells. The available therapies for degenerative diseases can only alleviate the symptoms of patients, while siRNA therapy drugs can upregulate gene expression, modify epigenetic changes, and stop the disease. In addition, siRNA also plays an important role in cardiovascular diseases, gastrointestinal diseases, and hepatitis B. However, free siRNA is easily degraded by nuclease and has a short half-life in the blood. Research has found that siRNA can be delivered to specific cells through appropriate vector selection and design to improve the therapeutic effect. The application of viral vectors is limited because of their high immunogenicity and low capacity, while non-viral vectors are widely used because of their low immunogenicity, low production cost, and high safety. This paper reviews the common non-viral vectors in recent years and introduces their advantages and disadvantages, as well as the latest application examples.

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“…For these reasons, natural (sodium alginate, chitosan), semi-synthetic (cellulose derivatives), and synthetic (polyacrylic acid) PEs are extensively investigated for different fields of application, including the biomedical field and drug delivery [52]. In fact, the interaction of water-soluble PEs with counterions, such as pharmaceutical drugs or dyes for bioimaging [40,53], generates stable self-assembled colloidal dispersions [54] or discrete nanoparticles [55,56] in which a high proportion of the counterion is electrostatically attached to the PEs, forming polyelectrolyte complexes (PECs) [52]. The PECs system behaves as a carrier, with a high proportion of drug/dye reversibly attached to the PEs as ionic pairs.…”

Section: Polyelectrolyte Ionic Complexesmentioning

confidence: 99%

“…The PECs system behaves as a carrier, with a high proportion of drug/dye reversibly attached to the PEs as ionic pairs. With organic counterions, non-electrostatic contributions, such as hydrogen bonding and hydrophobic interactions, would also play a role in the association process [55,57,58]. The ion-pair equilibrium in PECs is partially displaced by the addition of salts through ionic exchange but is not modified by the addition of non-electrolytes [59].…”

Section: Polyelectrolyte Ionic Complexesmentioning

confidence: 99%

Fluorescent Multifunctional Organic Nanoparticles for Drug Delivery and Bioimaging: A Tutorial Review

et al. 2022

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Fluorescent organic nanoparticles (FONs) are a large family of nanostructures constituted by organic components that emit light in different spectral regions upon excitation, due to the presence of organic fluorophores. FONs are of great interest for numerous biological and medical applications, due to their high tunability in terms of composition, morphology, surface functionalization, and optical properties. Multifunctional FONs combine several functionalities in a single nanostructure (emission of light, carriers for drug-delivery, functionalization with targeting ligands, etc.), opening the possibility of using the same nanoparticle for diagnosis and therapy. The preparation, characterization, and application of these multifunctional FONs require a multidisciplinary approach. In this review, we present FONs following a tutorial approach, with the aim of providing a general overview of the different aspects of the design, preparation, and characterization of FONs. The review encompasses the most common FONs developed to date, the description of the most important features of fluorophores that determine the optical properties of FONs, an overview of the preparation methods and of the optical characterization techniques, and the description of the theoretical approaches that are currently adopted for modeling FONs. The last part of the review is devoted to a non-exhaustive selection of some recent biomedical applications of FONs.

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Carrier in carrier: Catanionic vesicles based on amphiphilic cyclodextrins complexed with DNA as nanocarriers of doxorubicin

Cited by 9 publications

References 72 publications

Biomaterials in Drug Delivery: Advancements in Cancer and Diverse Therapies—Review

Biomaterials in Drug Delivery: Advancements in Cancer and Diverse Therapies—Review

Research Status and Prospect of Non-Viral Vectors Based on siRNA: A Review

Fluorescent Multifunctional Organic Nanoparticles for Drug Delivery and Bioimaging: A Tutorial Review

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