Carrier-Mediated Uptake of Cardenolides and of Quinolizidine Alkaloids by Larvae ofSyntomeida epilaisandUresiphita reversalis

Abstract

Artemisia annua L. (Compositae) has been found to contain approximately 8-10 times more artemisinic acid (1) than artemisinin (Qinghaosu) (2), a sesquiterpene lactone endoperoxide, responsible for antimalarial activity (1). Because of its greater abundance and suitable stereochemical configuration, artemisinic acid (1) is a useful chiral synthon for the preparation of biologically active products. Thus, 1 has been con

Arteannuin-B and its Spiro-isoxazoline Derivative Inhibits LPS Induced Pro-Inflammatory Responses in RAW 264.7 Macrophages and BALB/c Mice via down-regulation of NF-κβ/P38 MAPK Mediated Stress Signalling

“…Figure 1: Some isoxazoline based scaffolds products used as drugs On the other hand, heterocyclic scaffolds like substituted spirocyclic-2-isoxazolines are the structural building block of many biologically active scaffolds (Figure 1) and molecular leads in inflammation drug discovery [17][18][19][20][21]. The therapeutic efficacy of (1) has been investigated in recent years for its anti-neoplastic action in-vitro [22,23], apoptosis [23,24], antileukemia [24,25], and anti-proliferative activity in breast cancer cells, lung, cervical, and liver [25]. Previously, we have reported the synthesis and anti-inflammatory screening of spiro-isoxazoline stitched adducts of (1) which furnished (3-chlorophenyl)-2-spiroisoxazoline arteannuin B (2) as a potent compound with lower toxicity.…”

Arteannuin-B and (3-chlorophenyl)-2-spiroisoxazoline derivative exhibit anti-inflammatory effect in LPS-activated RAW 264.7 macrophages and Balb/c mice induced pro-inflammatory responses via down-regulation of NF-κB/P38 MAPK Signalling.

“…On the other hand, heterocyclics like substituted spirocyclic-2-isoxazolines are the structural building block of many biologically active scaffolds and molecular leads in inflammation drug discovery [17][18][19][20][21]. The therapeutic efficacy of 1 has been investigated in recent years for its anti-neoplastic activity in-vitro [22,23], apoptosis [23,24], anti-leukemia [24,25] and anti-proliferative activity in breast, lung, cervical, and liver cancer cells [25].…”

“…In our previous study, we have reported the synthesis and anti-inflammatory screening of spiro-isoxazoline adducts of 1 which furnished JR-9 derivative as a potent compound with lower toxicity [22] (Figure 1).…”