Carrier Rate of Factor XI Deficiency in Stunted Japanese Black Cattle

Watanabe, Daisaku; Hirano, Takashi; Sugimoto, Yoshikazu; Ogata, Yasuhiro; Abe, Shogo; Ando, Takaaki; Ohtsuka, Hiromichi; Kunieda, Tetsuo; Kawamura, Seiichi

doi:10.1292/jvms.68.1251

Cited by 9 publications

(7 citation statements)

References 26 publications

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“…These results suggested that cattle with growth retardation were susceptible to infectious disease. Furthermore, this data is consistent with the fact that the GR cattle in this study had contracted WCS with infectious enteritis in their neonatal periods and also with previous reports in which cattle with growth retardation tended to contract WCS [29,30].…”

Section: Discussionsupporting

confidence: 93%

“…These cattle do not have any obvious diseases, such as hereditary renal tubular dysplasia or bovine viral diarrhea, and are in good condition with normal appetites and activities [7,8,22,23,26,29,30]. Nevertheless, their body weights and heights are morbidly lower than the criteria of the Japanese Feeding Standard for Beef Cattle [1], even from the juvenile period [22,30].…”

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confidence: 99%

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Hormonal Differences in Peripheral Blood and Gene Profiling in the Liver and Lymphocytes in Japanese Black Cattle with Growth Retardation

Ishida

Yonezawa

Eirai³

et al. 2013

J. Vet. Med. Sci.

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ABSTRACT. Japanese Black cattle occasionally demonstrate growth retardation despite sufficient nutrient intake. To clarify hormonal and transcriptional characteristics, we investigated differences in blood components, including hormones, and differences in exhaustive gene expressions in the liver and peripheral lymphocytes of six cattle with growth retardation (GR cattle) and eight control cattle of the same age and pedigree with normal growth. Hematocrit values and concentrations of hemoglobin, serum albumin, total cholesterol, insulin-like growth factor 1 (IGF-1), thyroxine and insulin in GR cattle were significantly lower than those in controls. GR cattle also excreted higher levels of GH. We used three GR and three control cattle for a microarray analysis in the liver and found that 279 gene expressions were significantly different. However, gene expressions related to the GH-IGF-1 axis, such as the GH receptor and IGF-1, were not significantly different from those of controls. Immune-related gene expressions were significantly lower. To clarify these gene expression levels, peripheral lymphocytes were used for real-time RT-PCR. The expression rates of genes that were significantly lower in the liver, such as chemokine ligand 8, interferon gamma receptor 1 and immunoglobulin light chain VJ region were also significantly lower in three GR cattle than those in the three control cattle. These results suggest that the cause of growth retardation in the present study was due to other factors, not abnormal gene expressions of factors related to the GH-IGF-1 axis in the liver, and that GR cattle were susceptible to infectious disease.

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Section: Discussionsupporting

confidence: 93%

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confidence: 99%

Hormonal Differences in Peripheral Blood and Gene Profiling in the Liver and Lymphocytes in Japanese Black Cattle with Growth Retardation

Ishida

Yonezawa

Eirai³

et al. 2013

J. Vet. Med. Sci.

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“…In cattle, the disorder was recorded in the USA as early as 1969 10. Later it was recorded in Canadian11 and British cattle,1 as well as in Holstein and Japanese Black cattle 8, 12, 13…”

Section: Introductionmentioning

confidence: 98%

Sporadic incidence of factor XI deficiency in Holstein cattle

et al. 2008

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BACKGROUND: Factor XI (FXI) is a plasma serine protease involved in the early activation of the blood coagulation cascade. A survey of Holstein cattle, and Czech Simmental cattle crossed with Holstein, was done to determine whether animals heterozygous for FXI deficiency were present. Mutations in exon 12 and in exon 9 were analysed. RESULTS: The method used was based on the polymerase chain reaction and subsequent distinction of the length of fragments. In the panel analysed (279 Holsteins and 30 Simmentals), one heterozygous carrier of the recessive allele in exon 12 (a German Holstein cow) was found. Some authors have found that the frequency is high in some breeding lines and low in others. Evidently the lines in our analysis are part of the group with a low frequency. In exon 9, all the animals (100 Holsteins and 52 Simmentals), were homozygous wild type. To date, the mutation in exon 9 has been found only in Japanese black cattle, and its breed-specific occurrence was therefore not disconfirmed by our assay. CONCLUSION: Our results revealed a low occurrence of F11 mutant alleles. The DNA-based test determines all genotypes regardless of phenotype and FXI activity. This is important as veterinarians need a reliable method. Of course, the testing of numerous sires by molecular methods is not necessary from the breeders' point of view, but in breeding lines where testing is deemed appropriate heterozygous animals could be easily and surely detected.

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“…Watanabe et al [11] reported no clinical bleeding tendency in cattle with factor XI deficiency. However, several groups of investigators found that animals affected by factor XI deficiency in Canadian Holstein cattle showed a lower rate of fetal and * CORRESPONDENCE TO: KITAGAWA, H., Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.…”

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“…In Japan, however, there has been no report on its frequency in generally bred Japanese black cattle, though there was one on stunted Japanese black cattle [11]. We investigated the frequencies of the mutant gene in sires and dams of Japanese black cattle.…”

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Pedigree Analysis of Factor XI Deficiency in Japanese Black Cattle

Ohba

Takasu

Nishii

et al. 2008

The Journal of Veterinary Medical Science

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ABSTRACT. Using a DNA-based diagnostic test for factor XI deficiency in Japanese black cattle, we surveyed 123 cattle (42 sires and 81 dams) in Gifu and Hyogo prefectures, and calculated gene frequencies. In sires, we drew up the pedigree network of the cattle with the factor XI deficiency. Results showed that the mutated allele of factor XI deficiency was retroactive in at least 6 or more generations of sires. Frequencies of the mutant gene were higher at 26.4% in total, and at 33.3% in sires. All 7 cattle with the homozygote of mutated allele were clinically normal, and showed no bleeding episodes. The mutated allele of factor XI deficiency might be widespread among Japanese black cattle. KEY WORDS: factor XI deficiency, gene frequency, Japanese black cattle.

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Carrier Rate of Factor XI Deficiency in Stunted Japanese Black Cattle

Cited by 9 publications

References 26 publications

Hormonal Differences in Peripheral Blood and Gene Profiling in the Liver and Lymphocytes in Japanese Black Cattle with Growth Retardation

Hormonal Differences in Peripheral Blood and Gene Profiling in the Liver and Lymphocytes in Japanese Black Cattle with Growth Retardation

Sporadic incidence of factor XI deficiency in Holstein cattle

Pedigree Analysis of Factor XI Deficiency in Japanese Black Cattle

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