“…For example, using planar electrode substrates and modern screen printing andaor spin coating technologies, it should be possible to create coatings on the order of 2±5 mm thick (compared to the 20±40 mm thick ®lms employed here), and this should improve the¯ux nearly 10-fold, and hence decrease response times to several minutes. Further, it may be possible to incorporate the carrier into the very thin hydrophobic walls of small vesicles such as liposomes [24,25]. If the enzyme were incorporated within the core of such vesicles, and the vesicles were held in intimate contact with the working electrode via entrapment behind a dialysis membrane, the¯ux of carrier mediated substrate transport to the inside of the vesicle would be much faster than in the current experiments.…”