Carrot juice ingestion attenuates high fructose‐induced circulatory pro‐inflammatory mediators in weanling Wistar rats

Mahesh, Malleswarapu; Bharathi, Munugala; Reddy, Mooli Raja Gopal; Pappu, Pranati; Putcha, Uday Kumar; Vajreswari, Ayyalasomayajula; Jeyakumar, Shanmugam M.

doi:10.1002/jsfa.7906

Cited by 9 publications

(14 citation statements)

References 50 publications

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“…On the other hand, accumulating evidence suggested that yogurt, ingredients of diet such as fruit and vegetables are also beneficial for NAFLD. Carrot, apple, and probiotic yogurt have been suggested to benefit the NAFLD population. Therefore, based on previous research, we supposed that the results of this study are the combined effects of calorie restriction and ICR models.…”

Section: Discussionmentioning

confidence: 99%

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Diet Consisting of Balanced Yogurt, Fruit, and Vegetables Modifies the Gut Microbiota and Protects Mice against Nonalcoholic Fatty Liver Disease

Kong

Han

et al. 2019

Molecular Nutrition Food Res

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Background Calorie restriction (CR) is a therapeutically effective method for nonalcoholic fatty liver disease. However, the compliance of the CR method is relatively poor. New CR methods are needed. Methods and Results Each week, mice are given a 5‐day high‐fat diet (HFD) ad libitum plus 2 days of an intermittent calorie restriction (ICR) diet (50% calorie restriction) consisting of yogurt, fruit, and vegetables, for 16 weeks. The effect of the ICR diet model on the fatty liver of mice is examined. Compared with continuous HFD‐fed mice, the mice feeding HFD+ICR have lower body weight and hepatic steatosis, reduced serum lipid and transaminase levels, increased fatty acid oxidation gene of Cpt1a, and decreased hepatic lipid synthesis gene of Pparγ and Srebf‐1c, as well as improved insulin resistance and lower level of inflammation. Moreover, ICR reverses the dysbacteriosis in HFD group, including the lower Shannon diversity indexes and lower abundance of Lactobacillus. Conclusion An ICR diet consisting of yogurt, fruit, and vegetables attenuates the development of HFD‐induced hepatic steatosis in mice. Furthermore, HFD+ICR diet is associated with a different fecal microbiota that tends to be more similar to normal diet controls.

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Section: Discussionmentioning

confidence: 99%

“…Besides, yogurt, fruit, and vegetables also have benefit for NAFLD. Carrot juice administration attenuates the high fructose diet‐induced elevation of circulatory free fatty acid (FFA) and pro‐inflammatory mediators . It is also shown that the replacement of calories in the Western diet with apple pomace attenuated NAFLD risk …”

Section: Introductionmentioning

confidence: 99%

Diet Consisting of Balanced Yogurt, Fruit, and Vegetables Modifies the Gut Microbiota and Protects Mice against Nonalcoholic Fatty Liver Disease

Kong

Han

et al. 2019

Molecular Nutrition Food Res

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“…22 The activity of glycerol-3-phosphate dehydrogenase (GPDH) (EC 1.1.1.8) in RPWAT was measured, according to the method of Wise and Green. 22 The activity of glycerol-3-phosphate dehydrogenase (GPDH) (EC 1.1.1.8) in RPWAT was measured, according to the method of Wise and Green.…”

Section: )mentioning

confidence: 99%

“…15 The fatty acid desaturase (delta-9 desaturase [D9D]) activity indices (ratio of palmitoleic [C16:1] to palmitic [C16:0] acid and oleic [C18:1] to stearic [C18:0] acid; D9D-C16 and D9D-C18, respectively), the indicators of SCD1 activity, were calculated as reported earlier. 22…”

Section: Total Lipid Extraction and Fatty Acid Composition By Gas-lmentioning

confidence: 99%

“…Plasma retinol and RPWAT total retinol levels were quantified by reverse phase high-performance liquid chromatography (HPLC), according to the previously described method. 22 The activity of glycerol-3-phosphate dehydrogenase (GPDH) (EC 1.1.1.8) in RPWAT was measured, according to the method of Wise and Green. 23…”

Section: Retinol Quantification and Activity Of Glycerol-3-phosphatmentioning

confidence: 99%

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Vitamin A and its metabolic pathway play a determinant role in high‐fructose‐induced triglyceride accumulation of the visceral adipose depot of male Wistar rats

Reddy

Mahesh

Munikumar

et al. 2019

Cell Biochemistry & Function

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Here, we tested a hypothesis that vitamin A and/or its metabolic pathways are involved in the high-fructose-mediated alteration in adipose tissue biology. For this purpose, weanling male Wistar rats were provided with one of the following diets: control (C), control with vitamin A deficiency (C-VAD), high fructose (HFr), and HFr with VAD (HFr-VAD) for 16 weeks, except that half of the C-VAD diet-fed rats were shifted to HFr diet (C-VAD(s)HFr), after 8-week period. Compared with control, feeding of HFr diet significantly increased the triglyceride content (P ≤ .01) and thus adipocyte size (hypertrophy) (P ≤ .001) in visceral adipose depot; retroperitoneal white adipose tissue (RPWAT) and these changes were corroborated with de novo lipogenesis, as evidenced by the increased glycerol-3-phosphate dehydrogenase activity (P ≤ .01) and up-regulation of lipogenic pathway transcripts, fructose transporter, and aldehyde dehydrogenase 1 A1. On the contrary, the absence of vitamin A in the HFr diet (HFr-VAD) failed to exert these changes; however, it induced adipocyte hyperplasia. Further, vitamin A deficiency-mediated changes were reversed by replenishment, as evident from the group that was shifted from C-VAD to HFr diet.In conclusion, vitamin A and its metabolic pathway play a key determinant role in the high-fructose-induced triglyceride accumulation and adipocyte hypertrophy of visceral white adipose depot.Significance of the study: Here, we report the metabolic impact of high-fructose feeding under vitamin A-sufficient and vitamin A-deficient conditions. Feeding of high-fructose diet induced triglyceride accumulation and adipocyte hypertrophy of the visceral white adipose depots. These changes corroborated with augmented expression of vitamin A and lipid metabolic pathway genes. Contrarily, absence of vitamin A in the high-fructose diet did not elicit such responses, while vitamin A

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Oxidative Stress and Redox Signaling in the Pathophysiology of Liver Diseases

Mooli

Mukhi

Ramakrishnan

2022

Comprehensive Physiology

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The increased production of derivatives of molecular oxygen and nitrogen in the form of reactive oxygen species (ROS) and reactive nitrogen species (RNS) lead to molecular damage called oxidative stress. Under normal physiological conditions, the ROS generation is tightly regulated in different cells and cellular compartments. Any disturbance in the balance between the cellular generation of ROS and antioxidant balance leads to oxidative stress. In this article, we discuss the sources of ROS (endogenous and exogenous) and antioxidant mechanisms. We also focus on the pathophysiological significance of oxidative stress in various cell types of the liver. Oxidative stress is implicated in the development and progression of various liver diseases. We narrate the master regulators of ROS-mediated signaling and their contribution to liver diseases. Nonalcoholic fatty liver diseases (NAFLD) are influenced by a "multiple parallel-hit model" in which oxidative stress plays a central role. We highlight the recent findings on the role of oxidative stress in the spectrum of NAFLD, including fibrosis and liver cancer. Finally, we provide a brief overview of oxidative stress biomarkers and their therapeutic applications in various liver-related disorders. Overall, the article sheds light on the significance of oxidative stress in the pathophysiology of the liver.

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Carrot juice ingestion attenuates high fructose‐induced circulatory pro‐inflammatory mediators in weanling Wistar rats

Abstract: Carrot juice administration attenuated the high fructose diet-induced elevation of levels of circulatory FFA and pro-inflammatory mediators; MCP1 and hsCRP without affecting the adiposity and cell size of visceral fat depot; RPWAT. © 2016 Society of Chemical Industry.

Cited by 9 publications

References 50 publications

Diet Consisting of Balanced Yogurt, Fruit, and Vegetables Modifies the Gut Microbiota and Protects Mice against Nonalcoholic Fatty Liver Disease

Diet Consisting of Balanced Yogurt, Fruit, and Vegetables Modifies the Gut Microbiota and Protects Mice against Nonalcoholic Fatty Liver Disease

Vitamin A and its metabolic pathway play a determinant role in high‐fructose‐induced triglyceride accumulation of the visceral adipose depot of male Wistar rats

Oxidative Stress and Redox Signaling in the Pathophysiology of Liver Diseases

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