Carry-over of some Fusarium mycotoxins in tissues and eggs of chickens fed experimentally mycotoxin-contaminated diets

Tangni, Emmanuel K.; Pamel, Van; Huybrechts, Bart; Evelyne, Delezie; Hoeck, Els Van; Daeseleire, Els

doi:10.1016/j.fct.2020.111715

Cited by 27 publications

(16 citation statements)

References 42 publications

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“…Occurrences of mycotoxin residues in biological samples, especially animal source foods, were used to evaluate mycotoxin exposure in animals and assess the risk to human consumers [ 39 ]. Although various studies indicate that chicken eggs and meat are only minor contributors to human dietary mycotoxin exposure [ 40 , 41 ], chronic exposure to these low levels could have a negative impact on the health of human consumers [ 42 , 43 ]. Iqbal et al [ 44 ] reported the highest total AFs concentration of 8 μg/kg in livers of chickens compared with other organs, because the liver is the primary target organ of AFs.…”

Section: Mycotoxins In Poultry Food Products From Surveys Conducted In Ssamentioning

confidence: 99%

Mycotoxins in Poultry Feed and Feed Ingredients from Sub-Saharan Africa and Their Impact on the Production of Broiler and Layer Chickens: A Review

Ochieng

Scippo

Kemboi

et al. 2021

Toxins

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The poultry industry in sub-Saharan Africa (SSA) is faced with feed insecurity, associated with high cost of feeds, and feed safety, associated with locally produced feeds often contaminated with mycotoxins. Mycotoxins, including aflatoxins (AFs), fumonisins (FBs), trichothecenes, and zearalenone (ZEN), are common contaminants of poultry feeds and feed ingredients from SSA. These mycotoxins cause deleterious effects on the health and productivity of chickens and can also be present in poultry food products, thereby posing a health hazard to human consumers of these products. This review summarizes studies of major mycotoxins in poultry feeds, feed ingredients, and poultry food products from SSA as well as aflatoxicosis outbreaks. Additionally reviewed are the worldwide regulation of mycotoxins in poultry feeds, the impact of major mycotoxins in the production of chickens, and the postharvest use of mycotoxin detoxifiers. In most studies, AFs are most commonly quantified, and levels above the European Union regulatory limits of 20 μg/kg are reported. Trichothecenes, FBs, ZEN, and OTA are also reported but are less frequently analyzed. Co-occurrences of mycotoxins, especially AFs and FBs, are reported in some studies. The effects of AFs on chickens’ health and productivity, carryover to their products, as well as use of mycotoxin binders are reported in few studies conducted in SSA. More research should therefore be conducted in SSA to evaluate occurrences, toxicological effects, and mitigation strategies to prevent the toxic effects of mycotoxins.

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Section: Mycotoxins In Poultry Food Products From Surveys Conducted In Ssamentioning

confidence: 99%

Mycotoxins in Poultry Feed and Feed Ingredients from Sub-Saharan Africa and Their Impact on the Production of Broiler and Layer Chickens: A Review

Ochieng

Scippo

Kemboi

et al. 2021

Toxins

View full text Add to dashboard Cite

show abstract

“…AFB 1 residues have been observed in eggs only when the hen consumes a feed with a minimum AFB 1 concentration of 500 g/kg feed ( Oliveira et al., 2000 ). Another study indicated hen feed inoculated with DON and ZEA up to 2228, 820 μg/kg did not contaminate the eggs ( Emmanuel et al., 2020 ). The detection of AFB 1 , FB 1 and ZEA in egg samples in the current study gives an indirect indication that the feeds given to the hens may be contaminated with high levels of these toxins.…”

Section: Resultsmentioning

confidence: 99%

Assessment of mycotoxins (deoxynivalenol, zearalenone, aflatoxin B1 and fumonisin B1) in hen’s eggs in Jordan

Osaili

Al-Abboodi

Awawdeh

et al. 2022

Heliyon

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“…Fusarium mycotoxins are fungal pollutants found in crops, fruits, vegetables, and feed around the world, posing serious threat to human and animal health [22]. BEA, a non-legislated emergent mycotoxin, contaminates feed and food globally [23], as proven by in vitro and in vivo toxicity reports.…”

Section: Discussionmentioning

confidence: 99%

Role of Nrf2 Nucleus Translocation in Beauvericin-Induced Cell Damage in Rat Hepatocytes

Shi

Wang

et al. 2022

Toxins

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Beauvericin (BEA), a food-borne mycotoxin metabolite derived from the fungus Beauveria Bassiana, is proven to exhibit high hepatotoxicity. However, the molecular mechanism underlying BEA-induced liver damage is not fully understood. Herein, the effect of Nrf2 nuclear translocation-induced by BEA in hepatocytes was investigated. CCK8 solution was used to determine the appropriate concentrations of BEA (0, 1, 1.5 and 2 μmol/L), and BRL3A cells were then exposed to different concentrations of BEA for 12 h. Our results reveal that BEA exposure is associated with high cytotoxicity, lowered cell viability, damaged cellular morphology, and increased apoptosis rate. BEA could lead to oxidative damage through the overproduction of ROS and unbalanced redox, trigger the activation of Nrf2 signaling pathway and Nrf2 nuclear translocation for transcriptional activation of downstream antioxidative genes. Additionally, BEA treatment upregulated the expression of autophagy-related proteins (LC3, p62, Beclin1, and ATG5) indicating a correlation between Nrf2 activation and autophagy, which warrants further studies. Furthermore, ML385, an Nrf2 inhibitor, partially ameliorated BEA-induced cell injury while CDDO, an Nrf2 activator, aggravated liver damage. The present study emphasizes the role of Nrf2 nuclear translocation in BEA-induced oxidative stress associated with the hepatotoxic nature of BEA.

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Carry-over of some Fusarium mycotoxins in tissues and eggs of chickens fed experimentally mycotoxin-contaminated diets

Cited by 27 publications

References 42 publications

Mycotoxins in Poultry Feed and Feed Ingredients from Sub-Saharan Africa and Their Impact on the Production of Broiler and Layer Chickens: A Review

Mycotoxins in Poultry Feed and Feed Ingredients from Sub-Saharan Africa and Their Impact on the Production of Broiler and Layer Chickens: A Review

Assessment of mycotoxins (deoxynivalenol, zearalenone, aflatoxin B1 and fumonisin B1) in hen’s eggs in Jordan

Role of Nrf2 Nucleus Translocation in Beauvericin-Induced Cell Damage in Rat Hepatocytes

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