Given a non-necessarily Hausdorff, topologically free, twisted étale groupoid (G, L ), we consider its essential groupoid C*-algebra, denoted C * ess (G, L ), obtained by completing Cc(G, L ) with the smallest among all C*seminorms coinciding with the uniform norm on Cc(G (0) ). The inclusion of C*-algebrasis then proven to satisfy a list of properties characterizing it as what we call a weak Cartan inclusion. We then prove that every weak Cartan inclusion A, B , with B separable, is modeled by a topologically free, twisted étale groupoid, as above. In our second main result we give a necessary and sufficient condition for an inclusion of C*-algebras A, B to be modeled by a twisted étale groupoid based on the notion of canonical states. A simplicity criterion for C * ess (G, L ) is proven and many examples are provided.