Substitution boxes (S-boxes) are nonlinear mappings that represent one of the core parts of many cryptographic algorithms (ciphers). If S-box does not possess good properties, a cipher would be susceptible to attacks. To design suitable S-boxes, we can use heuristics as it allows significant freedom in the selection of required cryptographic properties. Unfortunately, with heuristics, one is seldom sure how good a trade-off between cryptographic properties is reached or if optimizing for one property optimizes implicitly for another property. In this paper, we consider what is to the best of our knowledge, the most detailed analysis of tradeoffs among S-box cryptographic properties. More precisely, we ask questions if one property is optimized, what is the worst possible value for some other property, and what happens if all properties are optimized. Our results show that while it is possible to reach a large variety of possible solutions, optimizing for a certain property would commonly result in good values for other properties. In turn, this suggests that a single-objective approach should be a method of choice unless some precise values for multiple properties are needed. CCS CONCEPTS • Security and privacy → Block and stream ciphers; • Computing methodologies → Discrete space search;